RU102511U1 - MULTI-BAND GENERATOR-SHAPER OF PULSE SEQUENCES OF MEDICAL AND BIOLOGICAL PURPOSE - Google Patents

Abstract

 A multi-band generator-generator of pulse sequences of medical and biological purposes, containing an electromagnetic oscillation generator, an external modulating signal converter, a modulator, an attenuator and an emitter, characterized in that a microprocessor and an amplitude modulator are additionally introduced, and the electromagnetic oscillation generator is made in the form of a multi-band from infralow to high frequencies of a set of controlled generators, the inputs of which are connected to the microprocessor, and their outputs with the input of the module a torus generating pulse sequences containing any higher of the generated frequencies as a carrier, modulated by electromagnetic waves of lower frequency generators separately or in any combination, while the output of the modulator in parallel with the output of the external modulating signal converter is connected to the input of the amplitude modulator, to the output of which an emitter is connected through the attenuator.

Description

The utility model relates to the field of medicine and biology and can be used in medical and biological devices for the formation of effects on biological objects, including humans, of radiation of various nature: electromagnetic, acoustic, optical, etc., in order to regulate their functional state.

There are various medical devices that emit electromagnetic waves of the EHF-wave range (see, for example, RF Patent No. 2099107, A61N 5/02, 1997). The device according to the specified patent contains a power source, a generator of electromagnetic waves with a tunable frequency, a node for generating control signals and an irradiator (emitter).

The disadvantage of this known device is the limitation of therapeutic possibilities due to the transfer of the modulation spectrum to the region of the range of ultrasonic frequencies only and not the use of therapeutically significant infra-low-frequency modulation.

Also known is a device for millimeter wave therapy according to RF Patent No. 2127616, A61N 5/02, 1999.03.20, comprising a power source, an indicator of the presence of a supply voltage, an indicator of the presence or absence of a modulated emitted signal, a controlled signal generator and an irradiator.

The disadvantage of this device is the limited therapeutic capabilities of a rigidly determined frequency range of 0.01-0.1 Hz controlled generator. It is known that biologically significant infra-low-frequency rhythms cover a wider range. The range of 0.01-0.1 Hz selected in the known device is important for the body, however, the statement of the authors of this invention that this range is close (or coincides) to the spectrum of signals produced by cells of organs and systems of the body is not entirely correct, since , it is well known from biophysics and cytology that the processes of the cellular and macromolecular levels are characterized by spectra of a substantially higher frequency range, including the MHz and GHz ranges (see, for example, Zaguskin S.L. et al. On the range of oscillation periods microstructures of living cells // Doklady USSR Academy of Sciences -.. 1984. - T.277, №6 -. S.1468-1471).

The closest analogue to the claimed technical solution can serve as a physiotherapeutic device according to RF Patent No. 2293581, A61N 7/00, 02.20.2007, Bull. No. 5. comprising an electromagnetic oscillation generator, an external modulating signal converter, a modulator and an attenuator.

The main disadvantage of this device is the lack of the possibility of operational variation of the frequency of the generator of electromagnetic waves in a wide range of frequencies, since the frequency of the generator in the range from hundreds of kHz to tens of MHz is set when tuning the device through the use of interchangeable quartz resonators. In addition, low frequencies (less than hundreds of kHz) fall out of the range of carrier frequencies

The present utility model is based on the solution of the problem of expanding the frequency range of the generated and generated in pulsed sequences of electromagnetic oscillations while simplifying the adjustment of the generation modes.

According to the utility model, this problem is solved due to the fact that the microprocessor and the amplitude modulator are additionally introduced, and the electromagnetic oscillation generator is made in the form of a multiband set of controlled low-frequency and high-frequency oscillators, the inputs of which are connected to the microprocessor, and their outputs with the input of the modulator forming pulse sequences containing, as a carrier, any higher of the generated frequencies, modulated by the electromagnetic oscillations of the lower frequency generators in discord or in any combination, while the output of the modulator in parallel with the output of the converter of the external modulating signal is connected to the input of the amplitude modulator, to the output of which an emitter is connected through the attenuator.

The applicant has not identified technical solutions that are identical to the claimed utility model, which allows us to conclude that it meets the criterion of "novelty."

The essence of the utility model is illustrated by drawings.

Figure 1 shows: a block diagram of the claimed utility model, figure 2-5 are examples of waveforms of the generated pulse sequences in different frequency ranges obtained on a digital oscilloscope Tektronix TPS 2024 (USA).

The device contains: 1 - a microprocessor, 2 - a multi-range set of controlled generators, 3 - a modulator that generates pulse sequences, 4 - an amplitude modulator, 5 - an external modulating signal converter, 6 - an attenuator, 7 - an emitter.

The device operates as follows.

Using the computer or the keyboard of the programmer, the operator sets the program of operation of microprocessor 1. Microprocessor 1, according to the program set by the operator, sets the frequency modes of operation of a set of controlled generators 2, the output signals of which are fed to the input of modulator 3, which forms pulse sequences. Moreover, the pulse sequences as a carrier can have any higher of the generated frequencies, modulated by the electromagnetic oscillations of the lower frequency generators separately or in any combination. Next, the signals of the generated pulse sequences are fed to the input of the amplitude modulator 4, which can additionally modulate the pulse sequence in accordance with the selected external modulation signal, for example, a musical or biological rhythm supplied to the input of the amplitude modulator 4 through an external modulating signal converter 5. From the output of the amplitude modulator the pulse sequence signal is supplied to the attenuator 6, which regulates the power level of the output signal, and then to the emitter 7, which can be used various types of emitters of medical and biological purposes: antenna, ultrasound, optoelectronic, etc. In the absence of external modulation, the pulse sequence signal generated by modulator 3 without transformations in the amplitude modulator 4 is fed to the attenuator 6 and from its output to the emitter 7.

Examples of oscillograms (digital oscilloscope Tektronix TPS 2024) of the generated pulse sequences obtained at the output of the experimental sample of the inventive utility model of the generator-driver:

- figure 2 - carrier frequency 32.768 MHz, the modulation frequency 8.3 kHz;

- figure 3 - the carrier frequency of 32.768 MHz, the modulation frequency of 0.25 Hz;

- figure 4 - the carrier frequency of 9.5 Hz, the modulation frequency of 0.25 Hz;

- figure 5 - the carrier frequency of 1.25 MHz, the frequency of the pulse modulation of 100 kHz in conjunction with the amplitude modulation of 16 kHz.

An example implementation of a utility model.

An experimental ultrasound source based on a crystal from an RG-07 quartz resonator was used as the emitter 7 of the utility model. The carrier frequency of the radiation is 8.75 MHz.

To determine the reactions of the whole organism to modulated low-intensity ultrasound radiation, a series of studies were conducted on volunteers. As the external modulating signal, musical rhythms were used, the electric signal of which was fed through the converter 5 to the input of the amplitude modulator 4. The generated signal was a combination of the carrier frequency of 8.75 MHz and the modulating frequency spectrum of the musical work, and reproduction in the audio range was excluded.

Studies were carried out according to the following method. 1 hour before the start of the studies, the patient was sampled from the finger for spectrometric analysis, which served as the basis for subsequent measurements. Immediately before the start of the study, blood sampling was repeated and indicators of the state of the main body systems were determined by the method of ART (autonomic resonance test). Spectrometry was carried out on an SF-2000 spectrophotometer at characteristic wavelengths that reflect the main metabolic systems of the body according to the method: “A method for the rapid assessment of the dynamics of the metabolism of the blood system”, Patent RU No. 2315306 from 01.20.2008; ART - in accordance with the guidelines of the Ministry of Health No. 99/96 / Vasilenko A.M. et al. - M., 2000. - 28 p .;

Then the patient was placed in a comfortable sitting position, an ultrasonic signal emitter was placed on the palm of his hand. Ultrasound exposure was 10 minutes. After that, blood was again taken for spectrometry, and then measurements were repeated twice after 5 and 30 minutes after the end of the exposure using the ART method. The results are presented in the form of state diagrams of the studied body systems after exposure in comparison with the initial state (control). In this case, the spectrograms (Fig.6 and Fig.8) show the difference in optical density relative to the base value, measured 1 hour before the study, which on the diagram corresponds to a zero level along the ordinate.

6 and 7 show the results of spectrometry and ART, respectively, when exposed to an unmodulated ultrasonic signal of a carrier frequency (8.75 MHz).

On Fig and Fig.9 - the same with the combination of the carrier frequency of 8.75 MHz and the modulating frequency spectrum of the musical work, which was chosen as the Moonlight Sonata (Beethoven).

On the spectrograms of Fig.6 and Fig.8, the deviations of the optical density of blood samples from the baseline to exposure are at the level of measurement error. After exposure to an unmodulated ultrasonic signal of a carrier frequency (8.75 MHz), a significant shift is observed in all regions of the spectrum, indicating a general excitation of the blood system. Modulated ultrasound caused a significant shift only in the frequency range 410-415 nm, corresponding to the Cora band associated with the electronic absorption spectrum of hemoglobin. That is, there is a certain selectivity.

In the first case (unmodulated radiation), the ART data (Fig. 7) showed a shift of functional systems to a hyperfunctional state (normal limits are 55-65 units), in the second (modulation) - small fluctuation of indicators with a tendency to normalization (Fig. 9).

The given example demonstrates significant differences in the body's response to modulated and unmodulated ultrasound. This only fragmentarily shows the effect of the claimed technical solution.

To confirm the fundamental possibility of using the claimed utility model for regulating the functional state of the human body, studies were conducted on volunteers (patients in a surgical clinic). For the impact, as in the above example, an ultrasonic signal was selected, which is a combination of a carrier frequency of 8.75 MHz and a modulating frequency spectrum of the musical rhythm.

The study involved 28 volunteers. The subjects were approximately the same age (49 years ± 5.6 years), which were divided into two groups equal in number and equivalent in number of men and women: the exposure group and the placebo group. In the last group, a complete simulation of the effect was performed without a signal. The subjects performed 5 procedures lasting 10 minutes daily with a functional state monitoring before and after each procedure.

The functional state of the subjects was determined by two methods: simple visual-motor reaction (PZMR) and assessment of the current mental state according to the method of B.S. Frolov (see: Frolov B.S., Ovechkina I.V. CMS hardware-software complex for assessment mental state. - M.: Arkhangelsk, 2002. - 99 p.), in which the nosological scale “Adaptability” was chosen as the main evaluation indicator.

Statistical processing of the obtained data was carried out by the method of variation statistics with the determination of the values of M ± m and the criterion of signs G (non-parametric criterion for connected samples).

Figure 10 shows the results of changes in the performance indicator, and figure 11 changes in the level of adaptability (Ad) in the study groups after applying the inventive utility model or placebo (control study) relative to the initial measurements (background study).

Table 1 shows the normative levels of performance assessment, relative to which the results of the study of both groups were compared.

Table 1 - Normative levels of performance assessment Operability Limited Normal Does not mean. reduced Reduced That means. reduced Normative indicators 4-3 3-2 2-1 1-0 0. (- 1)

Figure 10 shows that the initial level of performance (background study) was significantly reduced equally in each group of volunteers, which was typical for the examined contingent of the surgical clinic. A control study conducted after exposure using the utility model showed an increase in working capacity to the level of 1.9 ± 0.4 “Slightly reduced” (see table 1), i.e. almost approached the normal level of assessment (the result is statistically significant: the significance level is P <0.05), while in the placebo group there were no significant changes.

Background measurements of Ad in two groups (exposure and placebo) were almost equal (Fig. 11). A control study after completion of the procedures showed an increase in the level of adaptation in the exposure group to 63.1%, while in the placebo group no significant changes in Ad were noted. The achieved Ad indicator (63.1%) is even lower than the norm, but it already differs significantly from the initial level, which is a statistically significant result according to the criterion of signs G (significance level P <0.05).

Thus, the above results confirm the possibility of achieving, using the claimed utility model, its purpose in regulating human functional states.

Given the possibility of creating using the claimed utility model, many combinations of options for pulse sequences and amplitude modulations, this device can be used in various physiotherapeutic devices. This ensures that the claimed utility model meets the condition of patentability "industrial applicability".

The efficiency of the utility model consists in the fact that by introducing a microprocessor and a multi-range from infralow to high frequencies a set of controlled generators simplifies the installation of diverse variations in the frequency spectra of the signals affecting the object and their modulations, thereby allowing the selection of optimal modes of exposure to the body during physiotherapeutic treatment ( electromagnetic, ultrasonic, etc.). In addition, this useful model is of undoubted interest for experimental biomedical research, including the development of modern medical equipment.

Claims (1)

A multi-band generator-generator of pulse sequences of biomedical use, containing an electromagnetic oscillation generator, an external modulating signal converter, a modulator, an attenuator and an emitter, characterized in that a microprocessor and an amplitude modulator are additionally introduced, and the electromagnetic oscillation generator is made in the form of a multi-band from infralow to high frequencies of a set of controlled generators, the inputs of which are connected to the microprocessor, and their outputs with the input of the module a torus generating pulse sequences containing any higher of the generated frequencies as a carrier, modulated by electromagnetic waves of lower frequency generators separately or in any combination, while the output of the modulator in parallel with the output of the external modulating signal converter is connected to the input of the amplitude modulator, to the output of which an emitter is connected through the attenuator.