RS56177B1 - Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinocetan (folfiri) - Google Patents
Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinocetan (folfiri)Info
- Publication number
- RS56177B1 RS56177B1 RS20170801A RSP20170801A RS56177B1 RS 56177 B1 RS56177 B1 RS 56177B1 RS 20170801 A RS20170801 A RS 20170801A RS P20170801 A RSP20170801 A RS P20170801A RS 56177 B1 RS56177 B1 RS 56177B1
- Authority
- RS
- Serbia
- Prior art keywords
- irinocetan
- folfiri
- aflibercept
- fluorouracil
- composition
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/178—Lectin superfamily, e.g. selectins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11305490 | 2011-04-26 | ||
EP11306154 | 2011-09-15 | ||
PCT/EP2012/057542 WO2012146610A1 (en) | 2011-04-26 | 2012-04-25 | Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinocetan (folfiri) |
EP12717129.6A EP2701724B1 (en) | 2011-04-26 | 2012-04-25 | Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinocetan (folfiri) |
Publications (1)
Publication Number | Publication Date |
---|---|
RS56177B1 true RS56177B1 (en) | 2017-11-30 |
Family
ID=46001286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20170801A RS56177B1 (en) | 2011-04-26 | 2012-04-25 | Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinocetan (folfiri) |
Country Status (38)
Country | Link |
---|---|
US (1) | US11033606B2 (en) |
EP (2) | EP3210617A1 (en) |
JP (1) | JP6114257B2 (en) |
KR (2) | KR20190088568A (en) |
CN (1) | CN103608029A (en) |
AR (1) | AR086051A1 (en) |
AU (1) | AU2012247530B2 (en) |
BR (1) | BR112013027356A2 (en) |
CA (1) | CA2833592A1 (en) |
CL (1) | CL2013003082A1 (en) |
CO (1) | CO6811861A2 (en) |
CR (1) | CR20130547A (en) |
CY (1) | CY1120382T1 (en) |
DK (1) | DK2701724T3 (en) |
DO (1) | DOP2013000248A (en) |
EA (1) | EA025182B1 (en) |
EC (1) | ECSP13013044A (en) |
ES (1) | ES2637074T3 (en) |
GT (1) | GT201300260A (en) |
HR (1) | HRP20171216T1 (en) |
HU (1) | HUE034288T2 (en) |
IL (2) | IL228947B (en) |
JO (1) | JO3283B1 (en) |
LT (1) | LT2701724T (en) |
MA (1) | MA35130B1 (en) |
MX (1) | MX341348B (en) |
NI (1) | NI201300112A (en) |
PE (2) | PE20171516A1 (en) |
PL (1) | PL2701724T3 (en) |
PT (1) | PT2701724T (en) |
RS (1) | RS56177B1 (en) |
SG (2) | SG10201610829UA (en) |
SI (1) | SI2701724T1 (en) |
TW (1) | TWI599369B (en) |
UA (1) | UA114708C2 (en) |
UY (1) | UY34036A (en) |
WO (1) | WO2012146610A1 (en) |
ZA (1) | ZA201308821B (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3283B1 (en) | 2011-04-26 | 2018-09-16 | Sanofi Sa | Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinocetan (folfiri) |
US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
AU2013202947B2 (en) * | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
CN104853763A (en) * | 2012-08-02 | 2015-08-19 | 赛诺菲 | Article of manufacture comprising aflibercept or ziv-aflibercept |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
EP3170005B1 (en) | 2014-07-18 | 2019-04-10 | Sanofi | Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer |
CA2960890A1 (en) * | 2014-09-16 | 2016-03-24 | Regeneron Pharmaceuticals, Inc. | Predictive and prognostic biomarkers related to anti-angiogenic therapy of metastatic colorectal cancer |
US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
CA2992789A1 (en) | 2015-08-20 | 2017-02-23 | Ipsen Biopharm Ltd. | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
KR102714060B1 (en) | 2015-08-21 | 2024-10-08 | 입센 바이오팜 리미티드 | Method for treating metastatic pancreatic cancer using combination therapy comprising liposomal irinotecan and oxaliplatin |
KR101936049B1 (en) * | 2015-10-15 | 2019-01-08 | (주)알테오젠 | Method for manufacturing fusion proteins with IgG Fc domain |
EP3397276A4 (en) | 2015-12-30 | 2019-12-18 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
EA037406B1 (en) * | 2016-01-25 | 2021-03-25 | Санофи | Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer by measuring the level of a plasma biomarker |
MX2019004783A (en) | 2016-11-02 | 2019-08-12 | Ipsen Biopharm Ltd | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin). |
AU2019227997A1 (en) | 2018-03-02 | 2020-09-24 | Kodiak Sciences Inc. | IL-6 antibodies and fusion constructs and conjugates thereof |
BR112020022610A2 (en) | 2018-05-10 | 2021-02-09 | Regeneron Pharmaceuticals, Inc. | high concentration vegf receptor fusion protein containing formulations |
CA3101694A1 (en) * | 2018-05-30 | 2019-12-05 | David MACHOVER | Methods and pharmaceutical compositions for treating cancer |
WO2021050094A1 (en) * | 2019-09-11 | 2021-03-18 | Adverum Biotechnologies, Inc. | Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept |
WO2021072265A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6019790B2 (en) | 1977-11-18 | 1985-05-17 | 株式会社日立製作所 | Photocurable adhesive composition and method for bonding adherends using it |
US4353887A (en) | 1979-08-16 | 1982-10-12 | Ciba-Geigy Corporation | Divisible tablet having controlled and delayed release of the active substance |
JPS6019790A (en) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | Novel camptothecin derivative |
AU2309692A (en) | 1991-07-03 | 1993-02-11 | Cryolife, Inc. | Method for stabilization of biomaterials |
US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
WO1993022336A1 (en) | 1992-04-30 | 1993-11-11 | Alpha Therapeutic Corporation | Improved solubilization and stabilization of factor viii complex |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
EP0694042B1 (en) | 1993-03-25 | 2004-11-03 | Merck & Co. Inc. | Inhibitor of vascular endothelial cell growth factor |
US6811779B2 (en) | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
GB9410533D0 (en) | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | In situ hybridisation and immuno-Chemical localisation of a growth factor |
GB9410534D0 (en) | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | Improvements in or relating to growth factor inhibitors |
IL117684A (en) | 1995-04-07 | 2002-02-10 | Pharmacia & Upjohn Inc | Intermediates and process for the manufacture of camptothesin derivatives (cpt-11) and related compounds |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
JPH09154588A (en) | 1995-10-07 | 1997-06-17 | Toagosei Co Ltd | Vegf-binding polypeptide |
US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
ATE343400T1 (en) | 1996-09-24 | 2006-11-15 | Merck & Co Inc | COMPOUNDS FOR INHIBITING ANGIOGENESIS BY GENE THERAPY |
US7312196B2 (en) | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
DE19724793A1 (en) | 1997-06-06 | 1998-12-10 | Schering Ag | New peptides inhibit vascular endothelial cell growth factor |
US6075007A (en) | 1997-07-17 | 2000-06-13 | Regeneron Pharmaceuticals, Inc. | Modified noggin polypeptide and compositions |
JPH1180024A (en) | 1997-09-12 | 1999-03-23 | Toagosei Co Ltd | Corneal vascular rebirth inhibitor |
US6436897B2 (en) | 1998-06-01 | 2002-08-20 | Celtrix Pharmaceuticals, Inc. | Pharmaceutical formulations for IGF/IGFBP |
DE19841985A1 (en) | 1998-09-03 | 2000-03-09 | Schering Ag | New heterocyclic alkanesulfonic and alkane carboxylic acid derivatives are VEGF receptor blockers useful in treatment of e.g. psoriasis, rheumatoid arthritis, stroke, tumors and endometriosis |
US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
WO2000034337A1 (en) | 1998-12-10 | 2000-06-15 | Tsukuba Research Laboratory, Toagosei Co., Ltd. | Humanized monoclonal antibodies against vascular endothelial cell growth factor |
AP1243A (en) | 1999-02-01 | 2004-02-02 | Servier Lab | Core tablet for controlled release of gliclazide after oral administration. |
DE60011612T2 (en) | 1999-04-28 | 2005-07-07 | Board of Regents, The University of Texas System, Austin | Compositions and methods of cancer treatment by the selective inhibition of VEGF |
AU4564200A (en) | 1999-04-29 | 2000-11-17 | Aventis Pharma S.A. | Method for treating cancer using camptothecin derivatives and 5-fluorouracil |
US7306799B2 (en) | 1999-06-08 | 2007-12-11 | Regeneron Pharmaceuticals, Inc. | Use of VEGF inhibitors for treatment of eye disorders |
US7303746B2 (en) | 1999-06-08 | 2007-12-04 | Regeneron Pharmaceuticals, Inc. | Methods of treating eye disorders with modified chimeric polypeptides |
DE60041159D1 (en) | 1999-06-08 | 2009-01-29 | Regeneron Pharma | VEGF receptor chimeras for the treatment of ocular diseases characterized by vascular permeability. |
US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
US6833349B2 (en) | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
US7001892B1 (en) | 1999-06-11 | 2006-02-21 | Purdue Research Foundation | Pharmaceutical materials and methods for their preparation and use |
DE19938724A1 (en) | 1999-08-16 | 2001-02-22 | Tetra Laval Holdings & Finance | Device for the production of plastic containers by means of stretch blow molding |
GB0008269D0 (en) | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
US6500633B1 (en) | 2000-04-26 | 2002-12-31 | Atairgin Technologies, Inc. | Method of detecting carcinomas |
AR028424A1 (en) | 2000-05-10 | 2003-05-07 | Bayer Corp | METHOD FOR REGULATING ANGIOGENESIS USING RYK PROTEIN |
JP4340062B2 (en) | 2000-10-12 | 2009-10-07 | ジェネンテック・インコーポレーテッド | Concentrated protein preparation with reduced viscosity |
US20030092019A1 (en) | 2001-01-09 | 2003-05-15 | Millennium Pharmaceuticals, Inc. | Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia |
US20040023864A1 (en) | 2001-05-09 | 2004-02-05 | Steve Roczniak | Method of regulating angiogenesis using ryk protein |
WO2003009817A2 (en) | 2001-07-25 | 2003-02-06 | Protein Design Labs, Inc. | Stable lyophilized pharmaceutical formulation of igg antibodies |
ES2287495T3 (en) | 2002-03-01 | 2007-12-16 | Pfizer Italia S.R.L. | IRINOTECAN CHLORHYDRATE CRYSTORINE POLYMORPHY FORM. |
JP2004006671A (en) | 2002-03-22 | 2004-01-08 | Sanyo Electric Co Ltd | Charge coupled device and manufacturing method thereof |
MXPA05008972A (en) | 2003-03-28 | 2005-11-04 | Regeneron Pharma | Methods of treating diabetes by blocking vegf-mediated. |
CA2519408C (en) | 2003-04-04 | 2011-01-18 | Genentech, Inc. | High concentration antibody and protein formulations |
US7300654B2 (en) | 2003-05-28 | 2007-11-27 | Regeneron Pharmaceuticals, Inc. | Method of treating corneal transplant rejection in high risk keratoplasty patients |
MXPA05008973A (en) | 2003-05-28 | 2006-02-22 | Regeneron Pharma | Method of treating corneal transplant rejection. |
US7186699B2 (en) | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
WO2004110490A2 (en) | 2003-06-06 | 2004-12-23 | Regeneron Pharmaceuticals, Inc. | Use of vegf inhibitors for tumor regression |
US7399612B2 (en) | 2003-06-30 | 2008-07-15 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
AR046510A1 (en) | 2003-07-25 | 2005-12-14 | Regeneron Pharma | COMPOSITION OF A VEGF ANTAGONIST AND AN ANTI-PROLIFERATIVE AGENT |
US20050196340A1 (en) | 2003-08-06 | 2005-09-08 | Jocelyn Holash | Use of a VEGF antagonist in combination with radiation therapy |
AU2004264891A1 (en) | 2003-08-06 | 2005-02-24 | Regeneron Pharmaceuticals, Inc. | Use of a VEGF antagonist in combination with radiation therapy |
JP4812431B2 (en) | 2003-08-14 | 2011-11-09 | 富士通株式会社 | Computer equipment |
CA2876822C (en) | 2003-08-27 | 2015-11-17 | David Shima | Combination therapy for the treatment of ocular neovascular disorders |
EP1529620B1 (en) | 2003-11-06 | 2009-02-25 | Nestlé Waters Management & Technology | Process of manufacturing containers made of polyester resin |
EP1696949A4 (en) | 2003-11-10 | 2008-02-06 | Ghc Res Dev Corp | Vegf receptor antagonists |
WO2005072772A1 (en) | 2004-01-30 | 2005-08-11 | Suomen Punainen Risti Veripalvelu | Pharmaceutical compositions |
US7354580B2 (en) | 2004-06-10 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Method of administering and using VEGF inhibitors for the treatment of human cancer |
CN1968709A (en) | 2004-06-18 | 2007-05-23 | 瑞泽恩制药公司 | VEGF inhibitors for the treatment of malignant pleural effusion |
US7378095B2 (en) | 2004-07-30 | 2008-05-27 | Regeneron Pharmaceuticals, Inc. | Methods of treating type I diabetes by blocking VEGF-mediated activity |
DK1802334T3 (en) | 2004-10-21 | 2012-10-15 | Genentech Inc | Method of treating intraocular neovascular diseases |
FR2878749B1 (en) | 2004-12-03 | 2007-12-21 | Aventis Pharma Sa | ANTITUMOR COMBINATIONS CONTAINING IN VEGT INHIBITOR AGENT AND 5FU OR ONE OF ITS DERIVATIVES |
US7303748B2 (en) | 2005-02-02 | 2007-12-04 | Regeneron Pharmaceuticals, Inc. | Method of treating eye injury with local administration of a VEGF inhibitor |
US7354581B2 (en) | 2005-02-11 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a VEGF antagonist and anti-hypertensive agent |
CA2598452A1 (en) | 2005-03-11 | 2006-09-21 | Regeneron Pharmaceuticals, Inc. | Treating anemia by inhibition of vegf |
HUE027096T2 (en) | 2005-03-25 | 2016-08-29 | Regeneron Pharma | Vegf antagonist formulations |
MX2008001966A (en) | 2005-08-12 | 2008-03-26 | Regeneron Pharma | Methods of treating diseases with a vegf antagonist. |
US7354582B2 (en) | 2006-03-10 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Use of VEGF antagonists for the treatment of malignant gliomas |
WO2007149334A2 (en) | 2006-06-16 | 2007-12-27 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
NO347649B1 (en) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Human antibody or antibody fragment that specifically binds human delta-like ligand 4 (hDII4), nucleic acid molecule that codes for such and vector and host-vector systems, as well as method for production, composition and use. |
CA2680528A1 (en) | 2007-03-23 | 2008-10-02 | Precision Therapeutics, Inc. | Methods for evaluating angiogenic potential in culture |
FR2918279B1 (en) | 2007-07-05 | 2010-10-22 | Aventis Pharma Sa | ANTITUMOR COMBINATIONS CONTAINING A VEGF INHIBITOR AGENT AND IRINOTECAN |
CN100546578C (en) * | 2007-08-10 | 2009-10-07 | 河北医科大学 | A kind of anticancer pharmaceutical composition and the application in the preparation cancer therapy drug thereof |
EA024437B1 (en) | 2007-10-04 | 2016-09-30 | Оникс Терапьютикс, Инк. | Synthesis of amino acid keto-epoxides |
NZ628598A (en) | 2007-11-30 | 2016-09-30 | Genentech Inc | Vegf polymorphisms and anti-angiogenesis therapy |
EP2143542A1 (en) | 2008-07-07 | 2010-01-13 | Nestec S.A. | Method and apparatus for packaging a liquid food product |
FR2933702A1 (en) | 2008-07-08 | 2010-01-15 | Sanofi Aventis | SPECIFIC ANTAGONISTS OF FGF-R4 RECEPTOR |
US20100047314A1 (en) | 2008-08-22 | 2010-02-25 | Osteogenex Inc. | Folinic acid derivatives for promoting bone growth |
US20100093552A1 (en) | 2008-10-09 | 2010-04-15 | Asit Panja | Use and identification of biomarkers for gastrointestinal diseases |
EP2540843B1 (en) | 2008-11-05 | 2014-07-02 | Genentech, Inc. | Genetic polymorphisms in age-related macular degeneration |
SG174963A1 (en) | 2009-03-31 | 2011-11-28 | Roche Glycart Ag | Treatment of cancer with a humanized anti-egfr igg1 antibody and irinotecan |
US20120100134A1 (en) | 2009-04-24 | 2012-04-26 | University Of Southern California | Genetic variants in angiogenesis pathway associated with clinical outcome |
MX2012001085A (en) | 2009-07-31 | 2012-05-22 | Amcor Ltd | Hot-fill container. |
US8221753B2 (en) * | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
AU2012228544B2 (en) | 2011-02-23 | 2015-06-11 | Sanofi | Single nucleotide polymorphisms in the promoter of VEGFA gene and their use as predictive markers for anti-VEGF treatments |
JO3283B1 (en) | 2011-04-26 | 2018-09-16 | Sanofi Sa | Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinocetan (folfiri) |
JP6019790B2 (en) | 2012-06-19 | 2016-11-02 | 富士電機株式会社 | Joining method and joining member |
CN104853763A (en) | 2012-08-02 | 2015-08-19 | 赛诺菲 | Article of manufacture comprising aflibercept or ziv-aflibercept |
EP3170005B1 (en) * | 2014-07-18 | 2019-04-10 | Sanofi | Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer |
EA037406B1 (en) | 2016-01-25 | 2021-03-25 | Санофи | Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer by measuring the level of a plasma biomarker |
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