Jedinjenje sa formulom I:naznačeno time da:X8 je N, i X5 i X6 su CH;R7 je C5-20 arilna grupa po izboru supstituisana sa jednom ili više grupa izabranih iz grupe koja sadrži halo, hidroksil, nitro, cijano, karboksi, i tiol, ili C1-7alkil, C2-7alkenil, C2-7alkinil, C3-7cikloalkil, C3-7cikloalkenil, C3-20heterociklil, C5-20aril, C5-20heteroaril, etar, acil, estar, amido, amino, acilamido, ureido, aciloksi, tioetar, sulfoksid, sulfonil, tioamido i sulfonamino (svaka po izboru supstituisana sa jednom ili više izabranih iz grupe koja sadrži halo, hidroksil, nitro, cijano, karboksi, tiol, C1-7alkil, C2-7alkenil, C2-7alkinil, C3-7cikloalkil, C3-7cikloalkenil, C3-20heterociklil, C5-20aril, C5-20heteroaril, etar, acil, estar, amido, amino, acilamido, ureido, aciloksi, tioetar, sulfoksid, sulfonil, tioamido i sulfonamino);RN3 i RN4, zajedno sa azotom na kojeg su povezani, grade heterociklični prsten koji sadrži između 3 i 8 atoma u prstenu po izboru supstituisanih sa jednom ili više grupa izabranih iz grupe koja sadrži halo, hidroksil, nitro, cijano, karboksi, i tiol, ili C1-7alkil, C2-7alkenil, C2-7alkinil, C3-7cikloalkil, C3-7cikloalkenil, C3-20heterociklil, C5-20aril, C5-20heteroaril, etar, acil, estar, amido, amino, acilamido, ureido, aciloksi, tioetar, sulfoksid, sulfonil, tioamido i sulfonamino (svaka po izboru supstituisana sa jednom ili više izabranih iz grupe koja sadrži halo, hidroksil, nitro, cijano, karboksi, tiol, C1-7alkil, C2-7alkenil, C2-7alkinil, C3-7cikloalkil, C3-7cikloalkenil, C3-20heterociklil, C5-20aril, C5-20heteroaril, etar, acil, estar, amido, amino, acilamido, ureido, aciloksi, tioetar, sulfoksid, sulfonil, tioamido i sulfonamino);R2 je izabran iz NRN5RN6, C5-20 heteroarilne grupe po izboru supstituisane sa jednom ili više grupa izabranih iz grupe koja sadrži halo, hidroksil, nitro, cijano, karboksi, i tiol, ili C1-7alkil, C2-7alkenil, C2-7alkinil, C3-7cikloalkil, C3-7cikloalkenil, C3-20heterociklil, C5-20aril, C5-20heteroaril, etar, acil, estar, amido, amino, acilamido, ureido, aciloksi, tioetar, sulfoksid, sulfonil, tioamido i sulfonamino (svaka po izboru supstituisana sa jednom ili više izabranih iz grupe koja sadrži halo, hidroksil, nitro, cijano, karboksi, tiol, C1-7alkil, C2-7alkenil, C2-7alkinil, C3-7cikloalkil, C3-7cikloalkenil, C3-20heterociklil, C5-20aril, C5-20heteroaril, etar, acil, estar, amido, amino, acilamido, ureido, aciloksi, tioetar, sulfoksid, sulfonil, tioamido i sulfonamino), te C5-20 arilne grupe po izboru supstituisane sa jednom ili više grupa izabranih iz grupe koja sadrži halo, hidroksil, nitro, cijano, karboksi, i tiol, ili C1-7alkil, C2-7alkenil, C2-7alkinil, C3- 7cikloalkil, C3-7cikloalkenil, C3-20heterociklil, C5-20aril, C5-20heteroaril, etar, acil, estar, amido, amino, acilamido, ureido, aciloksi, tioetar, sulfoksid, sulfonil, tioamido i sulfonamino (svaka po izboru supstituisana sa jednom ili više izabranih iz grupe koja sadrži halo, hidroksil, nitro, cijano, karboksi, tiol, C1-7aCompound of Formula I: wherein: X8 is N, and X5 and X6 are CH; R7 is a C5-20 aryl group optionally substituted by one or more groups selected from the group consisting of halo, hydroxyl, nitro, cyano, carboxy. and thiol, or C1-7alkyl, C2-7alkenyl, C2-7alkynyl, C3-7cycloalkyl, C3-7cycloalkenyl, C3-20heterocyclyl, C5-20aryl, C5-20heteroaryl, ether, acyl, ester, amido, amino, acylamido, ureido, acyloxy, thioether, sulfoxide, sulfonyl, thioamido and sulfonamino (each optionally substituted by one or more selected from the group consisting of halo, hydroxyl, nitro, cyano, carboxy, thiol, C1-7alkyl, C2-7alkenyl, C2-7alkynyl, C3 -7cycloalkyl, C3-7cycloalkenyl, C3-20heterocyclyl, C5-20aryl, C5-20heteroaryl, ether, acyl, ester, amido, amino, acylamido, ureido, acyloxy, thioether, sulfoxide, sulfonyl, thioamido and sulfonamino); together with the nitrogen to which they are attached, form a heterocyclic ring containing between 3 and 8 ring atoms optionally substituted by one or more groups and selected from the group consisting of halo, hydroxyl, nitro, cyano, carboxy, and thiol, or C1-7alkyl, C2-7alkenyl, C2-7alkynyl, C3-7cycloalkyl, C3-7cycloalkenyl, C3-20heterocyclyl, C5-20aryl, C5- Heteroaryl, ether, acyl, ester, amido, amino, acylamido, ureido, acyloxy, thioether, sulfoxide, sulfonyl, thioamido and sulfonamino (each optionally substituted by one or more selected from the group consisting of halo, hydroxyl, nitro, cyano, carboxy , thiol, C1-7alkyl, C2-7alkenyl, C2-7alkynyl, C3-7cycloalkyl, C3-7cycloalkenyl, C3-20heterocyclyl, C5-20aryl, C5-20heteroaryl, ether, acyl, ester, amido, amino, acylamido, ureido, acyloxy , thioether, sulfoxide, sulfonyl, thioamido and sulfonamino); R2 is selected from NRN5RN6, C5-20 heteroaryl group optionally substituted by one or more groups selected from the group consisting of halo, hydroxyl, nitro, cyano, carboxy, and thiol, or C1-7alkyl, C2-7alkenyl, C2-7alkynyl, C3-7cycloalkyl, C3-7cycloalkenyl, C3-20 heterocyclyl, C5-20aryl, C5-20heteroaryl, ether, aci l, ester, amido, amino, acylamido, ureido, acyloxy, thioether, sulfoxide, sulfonyl, thioamido and sulfonamino (each optionally substituted by one or more selected from the group consisting of halo, hydroxyl, nitro, cyano, carboxy, thiol, C1 -7alkyl, C2-7alkenyl, C2-7alkynyl, C3-7cycloalkyl, C3-7cycloalkenyl, C3-20heterocyclyl, C5-20aryl, C5-20heteroaryl, ether, acyl, ester, amido, amino, acylamido, ureido, acyloxy, thioether , sulfonyl, thioamido and sulfonamino), and C5-20 aryl groups optionally substituted by one or more groups selected from the group consisting of halo, hydroxyl, nitro, cyano, carboxy, and thiol, or C1-7alkyl, C2-7alkenyl, C2 -7alkynyl, C3-7cycloalkyl, C3-7cycloalkenyl, C3-20heterocyclyl, C5-20aryl, C5-20heteroaryl, ether, acyl, ester, amido, amino, acylamido, ureido, acyloxy, thioether, sulfoxide, sulfonyl, thioamido and sulfonamide (each optionally substituted by one or more selected from the group consisting of halo, hydroxyl, nitro, cyano, carboxy, thiol, C1-7a