RS20201065A1 - Planar electrode for biosensors realized using repetitive fractal geometry - Google Patents

Planar electrode for biosensors realized using repetitive fractal geometry

Info

Publication number
RS20201065A1
RS20201065A1 RS20201065A RSP20201065A RS20201065A1 RS 20201065 A1 RS20201065 A1 RS 20201065A1 RS 20201065 A RS20201065 A RS 20201065A RS P20201065 A RSP20201065 A RS P20201065A RS 20201065 A1 RS20201065 A1 RS 20201065A1
Authority
RS
Serbia
Prior art keywords
repetitive
geometry
fractal
biosensors
realized
Prior art date
Application number
RS20201065A
Other languages
Serbian (sr)
Inventor
Vasa Dr Radonić
Jasmina Dr Vidić
Marko Dr Radović
Ivana Dr Gađanski
Original Assignee
Inst Biosens Istrazivacko Razvojni Inst Za Informacione Tehnologije Biosistema
Institut National De Recherche Pour Lagriculture Lalimentation Et Lenvironnement
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Biosens Istrazivacko Razvojni Inst Za Informacione Tehnologije Biosistema, Institut National De Recherche Pour Lagriculture Lalimentation Et Lenvironnement filed Critical Inst Biosens Istrazivacko Razvojni Inst Za Informacione Tehnologije Biosistema
Priority to RS20201065A priority Critical patent/RS20201065A1/en
Priority to EP21806053.1A priority patent/EP4213929A1/en
Priority to PCT/RS2021/000011 priority patent/WO2022050860A1/en
Publication of RS20201065A1 publication Critical patent/RS20201065A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage

Abstract

The planar electrode for biosensors realized by applying repetitive fractal geometry has for a novelty the way of constructing a system of three biosensor electrodes using the repeating fractal geometry until the level of third order. The realization of the invention includes repetitive geometry of the 1st order of the Sierpine fractal, but the invention also relates to the repetitive geometry of the Koch curve, Pean curve and Hilbert curve, and of the geometric shapes includes the three most common shapes square, circle and triangle. Repetitive geometry is the basis of the innovation of the invention, because the change in the design of the planar electrode with its parameters, which will be discussed in the detailed description, as well as the order of fractals, significantly contributes to the increased sensitivity of biosensors. The biosensor of the invention is realized by LTCC technology and screen printing, i.e. for the substrate from which the biosensor electrode was made, ceramic is used on which gold is applied by screen printing, although the invention includes silver, platinum and carbon pastes, but also other manufacturing technologies as well as substrate materials and further functionalization of electrode surfaces. On non-sintered ceramic strips cut by laser using the screen printing process, through specifically designed masks using a photo procedure, a conductive paste is applied in an innovative fractal shape. The non-sintered strips are then laminated for mechanical strength and baked for the sintering process of the paste and the substrate itself. The electrodes can then be functionalized with appropriate bioreceptors, which do not affect the sensitivity itself, but the specificity of analyte recognition.
RS20201065A 2020-09-04 2020-09-04 Planar electrode for biosensors realized using repetitive fractal geometry RS20201065A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
RS20201065A RS20201065A1 (en) 2020-09-04 2020-09-04 Planar electrode for biosensors realized using repetitive fractal geometry
EP21806053.1A EP4213929A1 (en) 2020-09-04 2021-08-30 Planar electrode for biosensors realized using repetitive fractal geometry
PCT/RS2021/000011 WO2022050860A1 (en) 2020-09-04 2021-08-30 Planar electrode for biosensors realized using repetitive fractal geometry

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RS20201065A RS20201065A1 (en) 2020-09-04 2020-09-04 Planar electrode for biosensors realized using repetitive fractal geometry

Publications (1)

Publication Number Publication Date
RS20201065A1 true RS20201065A1 (en) 2022-03-31

Family

ID=78592902

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20201065A RS20201065A1 (en) 2020-09-04 2020-09-04 Planar electrode for biosensors realized using repetitive fractal geometry

Country Status (3)

Country Link
EP (1) EP4213929A1 (en)
RS (1) RS20201065A1 (en)
WO (1) WO2022050860A1 (en)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050147964A1 (en) 2003-12-30 2005-07-07 Intel Corporation Methods for identifying a peptide that binds a geometrical shape
US8005526B2 (en) 2005-08-31 2011-08-23 The Regents Of The University Of Michigan Biologically integrated electrode devices
US7516002B2 (en) 2006-01-10 2009-04-07 Guardian Industries Corp. Rain sensor for detecting rain or other material on window of a vehicle or on other surface
ES2636664T3 (en) 2008-09-02 2017-10-06 The Governing Council Of The University Of Toronto Nanostructured microelectrodes and biodetection devices that incorporate them
EP3369828B1 (en) 2011-02-07 2020-07-15 The Governing Council Of The University Of Toronto Bioprobes and methods of use thereof
US9613911B2 (en) 2013-02-06 2017-04-04 The Board Of Trustees Of The University Of Illinois Self-similar and fractal design for stretchable electronics
JP6440260B2 (en) 2013-02-06 2018-12-19 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ Stretchable electronic system with storage room
AU2014292984A1 (en) * 2013-07-24 2015-11-19 California Institute Of Technology Design and fabrication of implantable fully integrated electrochemical sensors
CA2948010A1 (en) * 2014-04-15 2015-10-22 Medella Health Inc. Functional contact lens and related systems and methods
US20160235347A1 (en) * 2015-02-13 2016-08-18 Maarij Baig Artificial sensors and methods of manufacture thereof
EP3562929A4 (en) 2016-12-29 2020-06-24 Ador Diagnostics S.r.l. An electrophoretic chip for electrophoretic applications
US20190030318A1 (en) 2017-07-27 2019-01-31 Purdue Research Foundation Fractal geometry microelectrodes and uses thereof

Also Published As

Publication number Publication date
WO2022050860A1 (en) 2022-03-10
EP4213929A1 (en) 2023-07-26

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