RS20120482A1 - Diterpene compounds with antineoplastic activities and pharmaceutical compositions comprising same - Google Patents

Diterpene compounds with antineoplastic activities and pharmaceutical compositions comprising same

Info

Publication number
RS20120482A1
RS20120482A1 RS20120482A RSP20120482A RS20120482A1 RS 20120482 A1 RS20120482 A1 RS 20120482A1 RS 20120482 A RS20120482 A RS 20120482A RS P20120482 A RSP20120482 A RS P20120482A RS 20120482 A1 RS20120482 A1 RS 20120482A1
Authority
RS
Serbia
Prior art keywords
compounds
same
pharmaceutical compositions
family
antineoplastic activities
Prior art date
Application number
RS20120482A
Other languages
Serbian (sr)
Inventor
Dragan POVRENOVIĆ
Nada IVKOVIĆ
Vele Tešević
Vlatka Vajs
Goran MILOSAVLJEVIĆ
Ivana ALJANČIĆ
Vojin Senk
Đuro KUTLAČA
Milica PEŠIĆ
Jasna BANKOVIĆ
Nikola TANIĆ
Sabera RUZDIJIĆ
Milka Jadranin
Nina TODOROVIĆ
Slobodan Milosavljević
Original Assignee
Nada IVKOVIĆ
Goran MILOSAVLJEVIĆ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nada IVKOVIĆ, Goran MILOSAVLJEVIĆ filed Critical Nada IVKOVIĆ
Publication of RS20120482A1 publication Critical patent/RS20120482A1/en
Publication of RS58784B1 publication Critical patent/RS58784B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/32—All rings being cycloaliphatic the ring system containing at least eleven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings

Abstract

The present invention provides a generic formulation of a family of novel diterpene compounds with antineoplastic activities. Contrary to existing pharmaceuticals used for anticancer treatment, the compounds exhibit extremely low toxicity, and, at therapeutical doses, even stimulate the proliferation of human lymphocytes. Compounds from the family have been found to show particularly selective cytotoxicity against several different cancer cell lines, while having immunostimulating effects on human lymphocytes. The compounds are useful in effective treatment of cancers, particularly leukemia.
RS20120482A 2010-05-06 2010-05-06 Diterpene compounds with antineoplastic activities and pharmaceutical compositions comprising same RS58784B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RS2010/000004 WO2011139172A1 (en) 2010-05-06 2010-05-06 Diterpene compounds with antineoplastic activities and pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
RS20120482A1 true RS20120482A1 (en) 2013-06-28
RS58784B1 RS58784B1 (en) 2019-06-28

Family

ID=43741940

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20120482A RS58784B1 (en) 2010-05-06 2010-05-06 Diterpene compounds with antineoplastic activities and pharmaceutical compositions comprising same

Country Status (2)

Country Link
RS (1) RS58784B1 (en)
WO (1) WO2011139172A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104165961A (en) * 2014-08-29 2014-11-26 四川汇宇制药有限公司 Detection method of related substances in docetaxel raw material
CN108640890B (en) * 2018-04-10 2020-05-05 山东省分析测试中心 Method for separating and purifying cembrane type macrocyclic diterpenoid compounds in frankincense
CN113710681A (en) * 2019-01-30 2021-11-26 罗特哈姆斯泰德研究有限公司 Dehydroepiloside cyclic dimers and derivatives thereof isolated from Salix species for cancer therapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3805965A1 (en) 1988-02-25 1989-09-07 Tamas Geb Szenasi Eszter USE OF THE EUPHORBIA HIRTA L. PLANT AND ITS EXTRACTS AND ITS ACTIVE SUBSTANCES
DE4102054A1 (en) 1991-01-24 1992-07-30 Geb Szenasi Tamas Euphorbia hirta L. to increase immunity - e.g. against influenza, winter colds and AIDS and as antifungal agent to treat open wounds
HU208790B (en) 1991-12-05 1994-01-28 Tamas Process for producing pharmaceutical compositions against arc and aids, comprising euphorbia hirta l. plant or its parts or their extracts
JPH08245505A (en) * 1994-09-09 1996-09-24 Tosoh Corp Diterpene derivative, its production and antitumor agent containing the same as active ingredient
AUPO864097A0 (en) * 1997-08-19 1997-09-11 Peplin Pty Ltd Anti-cancer compounds
US6333348B1 (en) 1999-04-09 2001-12-25 Aventis Pharma S.A. Use of docetaxel for treating cancers
AUPQ923100A0 (en) 2000-08-07 2000-08-31 Peplin Research Pty Ltd Treatment of prostate cancer

Also Published As

Publication number Publication date
WO2011139172A1 (en) 2011-11-10
RS58784B1 (en) 2019-06-28

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