RS20120482A1 - Diterpene compounds with antineoplastic activities and pharmaceutical compositions comprising same - Google Patents
Diterpene compounds with antineoplastic activities and pharmaceutical compositions comprising sameInfo
- Publication number
- RS20120482A1 RS20120482A1 RS20120482A RSP20120482A RS20120482A1 RS 20120482 A1 RS20120482 A1 RS 20120482A1 RS 20120482 A RS20120482 A RS 20120482A RS P20120482 A RSP20120482 A RS P20120482A RS 20120482 A1 RS20120482 A1 RS 20120482A1
- Authority
- RS
- Serbia
- Prior art keywords
- compounds
- same
- pharmaceutical compositions
- family
- antineoplastic activities
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/78—Benzoic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/32—All rings being cycloaliphatic the ring system containing at least eleven carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a generic formulation of a family of novel diterpene compounds with antineoplastic activities. Contrary to existing pharmaceuticals used for anticancer treatment, the compounds exhibit extremely low toxicity, and, at therapeutical doses, even stimulate the proliferation of human lymphocytes. Compounds from the family have been found to show particularly selective cytotoxicity against several different cancer cell lines, while having immunostimulating effects on human lymphocytes. The compounds are useful in effective treatment of cancers, particularly leukemia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/RS2010/000004 WO2011139172A1 (en) | 2010-05-06 | 2010-05-06 | Diterpene compounds with antineoplastic activities and pharmaceutical compositions comprising same |
Publications (2)
Publication Number | Publication Date |
---|---|
RS20120482A1 true RS20120482A1 (en) | 2013-06-28 |
RS58784B1 RS58784B1 (en) | 2019-06-28 |
Family
ID=43741940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20120482A RS58784B1 (en) | 2010-05-06 | 2010-05-06 | Diterpene compounds with antineoplastic activities and pharmaceutical compositions comprising same |
Country Status (2)
Country | Link |
---|---|
RS (1) | RS58784B1 (en) |
WO (1) | WO2011139172A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104165961A (en) * | 2014-08-29 | 2014-11-26 | 四川汇宇制药有限公司 | Detection method of related substances in docetaxel raw material |
CN108640890B (en) * | 2018-04-10 | 2020-05-05 | 山东省分析测试中心 | Method for separating and purifying cembrane type macrocyclic diterpenoid compounds in frankincense |
EP3917940A1 (en) * | 2019-01-30 | 2021-12-08 | Rothamsted Research Ltd | Cylodimer of dehydrosalicortin and derivatives thereof isolated from plant of the genus salix for use in cancer therapy |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3805965A1 (en) | 1988-02-25 | 1989-09-07 | Tamas Geb Szenasi Eszter | USE OF THE EUPHORBIA HIRTA L. PLANT AND ITS EXTRACTS AND ITS ACTIVE SUBSTANCES |
DE4102054A1 (en) | 1991-01-24 | 1992-07-30 | Geb Szenasi Tamas | Euphorbia hirta L. to increase immunity - e.g. against influenza, winter colds and AIDS and as antifungal agent to treat open wounds |
HU208790B (en) | 1991-12-05 | 1994-01-28 | Tamas | Process for producing pharmaceutical compositions against arc and aids, comprising euphorbia hirta l. plant or its parts or their extracts |
JPH08245505A (en) * | 1994-09-09 | 1996-09-24 | Tosoh Corp | Diterpene derivative, its production and antitumor agent containing the same as active ingredient |
AUPO864097A0 (en) * | 1997-08-19 | 1997-09-11 | Peplin Pty Ltd | Anti-cancer compounds |
US6333348B1 (en) | 1999-04-09 | 2001-12-25 | Aventis Pharma S.A. | Use of docetaxel for treating cancers |
AUPQ923100A0 (en) | 2000-08-07 | 2000-08-31 | Peplin Research Pty Ltd | Treatment of prostate cancer |
-
2010
- 2010-05-06 WO PCT/RS2010/000004 patent/WO2011139172A1/en active Application Filing
- 2010-05-06 RS RS20120482A patent/RS58784B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
RS58784B1 (en) | 2019-06-28 |
WO2011139172A1 (en) | 2011-11-10 |
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