RO99792B1 - Process for crystallizing erithromicine - Google Patents

Process for crystallizing erithromicine

Info

Publication number
RO99792B1
RO99792B1 RO131359A RO13135987A RO99792B1 RO 99792 B1 RO99792 B1 RO 99792B1 RO 131359 A RO131359 A RO 131359A RO 13135987 A RO13135987 A RO 13135987A RO 99792 B1 RO99792 B1 RO 99792B1
Authority
RO
Romania
Prior art keywords
erithromicine
crystallizing
anhydration
niu
decolorization
Prior art date
Application number
RO131359A
Other languages
Romanian (ro)
Inventor
Stefan Luca
Xenia Graunte
Cristina Mihai
Nicolae Ghiurco
Original Assignee
Institutul De Cercetari Chimico-Farmaceutice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institutul De Cercetari Chimico-Farmaceutice filed Critical Institutul De Cercetari Chimico-Farmaceutice
Priority to RO131359A priority Critical patent/RO99792B1/en
Publication of RO99792B1 publication Critical patent/RO99792B1/en

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedeul conform inventiei consta în aceea ca o solutie diclometanica de eritromicina cu activitate de 50000...60000 niu/ml, dupa decolorare si anhidrizare, se aduce la temperatura de -15...-25 degree C, de preferinta -18...-20 degree C timp de 6 h, se filtreaza si produsul obtinut se spala cu clorura de metilen racita la -20 degree C.The process according to the invention consists in that a dichloromethane solution of erythromycin with activity of 50000 to 60000 niu / ml, after decolorization and anhydration, is brought to a temperature of -15 ... 25 ° C, preferably -18 ° C. 20 ° C for 6 hours, filtered and the product obtained was washed with methylene chloride cooled to -20 ° C.

RO131359A 1987-12-28 1987-12-28 Process for crystallizing erithromicine RO99792B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RO131359A RO99792B1 (en) 1987-12-28 1987-12-28 Process for crystallizing erithromicine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO131359A RO99792B1 (en) 1987-12-28 1987-12-28 Process for crystallizing erithromicine

Publications (1)

Publication Number Publication Date
RO99792B1 true RO99792B1 (en) 1990-06-29

Family

ID=40907849

Family Applications (1)

Application Number Title Priority Date Filing Date
RO131359A RO99792B1 (en) 1987-12-28 1987-12-28 Process for crystallizing erithromicine

Country Status (1)

Country Link
RO (1) RO99792B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048786A1 (en) * 2008-10-29 2010-05-06 广东东阳光药业有限公司 Crystallizing method of erythromycin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048786A1 (en) * 2008-10-29 2010-05-06 广东东阳光药业有限公司 Crystallizing method of erythromycin
US20110172402A1 (en) * 2008-10-29 2011-07-14 Sunshine Lake Pharma Co., Ltd Crystallizing method of erythromycin

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