RO99792B1 - Process for crystallizing erithromicine - Google Patents
Process for crystallizing erithromicineInfo
- Publication number
- RO99792B1 RO99792B1 RO131359A RO13135987A RO99792B1 RO 99792 B1 RO99792 B1 RO 99792B1 RO 131359 A RO131359 A RO 131359A RO 13135987 A RO13135987 A RO 13135987A RO 99792 B1 RO99792 B1 RO 99792B1
- Authority
- RO
- Romania
- Prior art keywords
- erithromicine
- crystallizing
- anhydration
- niu
- decolorization
- Prior art date
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedeul conform inventiei consta în aceea ca o solutie diclometanica de eritromicina cu activitate de 50000...60000 niu/ml, dupa decolorare si anhidrizare, se aduce la temperatura de -15...-25 degree C, de preferinta -18...-20 degree C timp de 6 h, se filtreaza si produsul obtinut se spala cu clorura de metilen racita la -20 degree C.The process according to the invention consists in that a dichloromethane solution of erythromycin with activity of 50000 to 60000 niu / ml, after decolorization and anhydration, is brought to a temperature of -15 ... 25 ° C, preferably -18 ° C. 20 ° C for 6 hours, filtered and the product obtained was washed with methylene chloride cooled to -20 ° C.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RO131359A RO99792B1 (en) | 1987-12-28 | 1987-12-28 | Process for crystallizing erithromicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RO131359A RO99792B1 (en) | 1987-12-28 | 1987-12-28 | Process for crystallizing erithromicine |
Publications (1)
Publication Number | Publication Date |
---|---|
RO99792B1 true RO99792B1 (en) | 1990-06-29 |
Family
ID=40907849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO131359A RO99792B1 (en) | 1987-12-28 | 1987-12-28 | Process for crystallizing erithromicine |
Country Status (1)
Country | Link |
---|---|
RO (1) | RO99792B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010048786A1 (en) * | 2008-10-29 | 2010-05-06 | 广东东阳光药业有限公司 | Crystallizing method of erythromycin |
-
1987
- 1987-12-28 RO RO131359A patent/RO99792B1/en unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010048786A1 (en) * | 2008-10-29 | 2010-05-06 | 广东东阳光药业有限公司 | Crystallizing method of erythromycin |
US20110172402A1 (en) * | 2008-10-29 | 2011-07-14 | Sunshine Lake Pharma Co., Ltd | Crystallizing method of erythromycin |
CN101724000B (en) * | 2008-10-29 | 2012-05-30 | 广东东阳光药业有限公司 | Crystallization method of erythrocin |
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