RO96328B1 - Process for preparing dehydrobenzofuran and chroman-carboxamide derivatives - Google Patents
Process for preparing dehydrobenzofuran and chroman-carboxamide derivativesInfo
- Publication number
- RO96328B1 RO96328B1 RO126819A RO12681987A RO96328B1 RO 96328 B1 RO96328 B1 RO 96328B1 RO 126819 A RO126819 A RO 126819A RO 12681987 A RO12681987 A RO 12681987A RO 96328 B1 RO96328 B1 RO 96328B1
- Authority
- RO
- Romania
- Prior art keywords
- group
- formula
- page
- dehydrobenzofuran
- chroman
- Prior art date
Links
- AFYJYAWBTFNDAN-UHFFFAOYSA-N 3,4-dihydro-2h-chromene-2-carboxamide Chemical class C1=CC=C2OC(C(=O)N)CCC2=C1 AFYJYAWBTFNDAN-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- -1 cyclohexenylmethyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000006125 ethylsulfonyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Procedeu pentru prepararea unor derivati de dehidrobenzofuran-si croman-carboxamide cu formula generala I (vezi formula în pag.1 a descrierii) în care R si R' reprezinta, independent unul de altul, atomi de hidrogen sau grupari metil, n este egal cu 1 sau 2, m este egal cu 1 sau 2, Z este o grupare dietilamino sau o grupare cu formula a (vezi formula în pag.1 a descrierii) în care R3 este o grupare etil, alil, ciclopropilmetil sau ciclohexenilmetil, X este un atom de hidrogen, o grupare amino, metoxi sau metil, Y este un atom de hidrogen sau de clor, o grupare etilsulfonil, caracterizat prin aceea ca un acid cu formula generala II (vezi formula în pag.1 a descrierii) în care Y, X, R, n sînt definiti ca mai înainte, se trateaza cu o amina cu formula generala III (vezi formula în pag.1 a descrierii) în care Z, R' si m sînt definiti ca mai înainte, în prezenta unui solvent, ales dintre cloroform, acetona, metiletilcetona sau dimetilformamida, la o temperatura cuprinsa între 5 degree C si temperatura ambianta.Process for the preparation of dehydrobenzofuran- and chroman-carboxamide derivatives of the general formula I (see formula on page 1 of the description) wherein R and R 'independently of one another represent hydrogen or methyl groups n is equal to 1 or 2, m is equal to 1 or 2, Z is a diethylamino group or a group of formula (wherein the formula in page 1 of the description) wherein R3 is an ethyl, allyl, cyclopropylmethyl or cyclohexenylmethyl group, X is a a hydrogen atom, an amino, methoxy or methyl group, Y is a hydrogen or chlorine atom, an ethylsulfonyl group, characterized in that an acid of general formula II (see formula on page 1 of the specification) wherein Y, X, R, n are as hereinbefore defined, is treated with an amine of general formula III (see formula on page 1 of the description) wherein Z, R 'and m are as hereinbefore defined, in the presence of a solvent selected from chloroform, acetone, methyl ethyl ketone or dimethylformamide at a temperature between 5 degrees C and ambient temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO126819A RO96328B1 (en) | 1987-01-29 | 1987-01-29 | Process for preparing dehydrobenzofuran and chroman-carboxamide derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO126819A RO96328B1 (en) | 1987-01-29 | 1987-01-29 | Process for preparing dehydrobenzofuran and chroman-carboxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO96328B1 true RO96328B1 (en) | 1989-04-01 |
Family
ID=40905135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO126819A RO96328B1 (en) | 1987-01-29 | 1987-01-29 | Process for preparing dehydrobenzofuran and chroman-carboxamide derivatives |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO96328B1 (en) |
-
1987
- 1987-01-29 RO RO126819A patent/RO96328B1/en unknown
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