RO95505A3 - PROCEDURE FOR OBTAINING A PRAZOLIDINE DERIVATIVE - Google Patents
PROCEDURE FOR OBTAINING A PRAZOLIDINE DERIVATIVEInfo
- Publication number
- RO95505A3 RO95505A3 RO86124678A RO12467886A RO95505A3 RO 95505 A3 RO95505 A3 RO 95505A3 RO 86124678 A RO86124678 A RO 86124678A RO 12467886 A RO12467886 A RO 12467886A RO 95505 A3 RO95505 A3 RO 95505A3
- Authority
- RO
- Romania
- Prior art keywords
- ethyl
- butazone
- toluene
- phenyl
- prazolidine
- Prior art date
Links
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 5
- 235000019441 ethanol Nutrition 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 229960004756 ethanol Drugs 0.000 abstract 2
- 229960002895 phenylbutazone Drugs 0.000 abstract 2
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 abstract 2
- SODPIMGUZLOIPE-UHFFFAOYSA-N (4-chlorophenoxy)acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1 SODPIMGUZLOIPE-UHFFFAOYSA-N 0.000 abstract 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- UORGKWWJEQDTGX-UHFFFAOYSA-N clofexamide Chemical compound CCN(CC)CCNC(=O)COC1=CC=C(Cl)C=C1 UORGKWWJEQDTGX-UHFFFAOYSA-N 0.000 abstract 1
- 229960001417 clofexamide Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- -1 iso-propyl-alochol Chemical compound 0.000 abstract 1
- SCZVXVGZMZRGRU-UHFFFAOYSA-N n'-ethylethane-1,2-diamine Chemical compound CCNCCN SCZVXVGZMZRGRU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 abstract 1
- 239000008096 xylene Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
A pyrazolidine deriv. pharmaceutical cpd. consists of a molecular combination of dofexamide and phenyl-butazone. Ze chofexamide is the result of a reaction between 4-chlorophenoxy-acetic-acid and NN-di;ethyl-amino-ethyl-amine. Above is the subject of the main invention RSR No.91023. Here are attempt is made to improve the purity of the prod. namely: clofexamide dissolved in toluene (or xylene) is brought into contact with phenyl-butazone in the presence of polar solvents as acetone, iso-propyl-alochol, ethyl-alcohol in vol. proportions of 1:1 and respectively 1:5 and 1:6 based on toluene/or tylene) at a temp. 10-25 deg.C. is obtd. by filtration at 1-10 deg.C, and is recrystallised from lower alcohols, as ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO124678A RO95505B1 (en) | 1986-09-03 | 1986-09-03 | Process for preparing a pyrazolidine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO124678A RO95505B1 (en) | 1986-09-03 | 1986-09-03 | Process for preparing a pyrazolidine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO95505A3 true RO95505A3 (en) | 1988-09-30 |
| RO95505B1 RO95505B1 (en) | 1988-10-02 |
Family
ID=20119808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO124678A RO95505B1 (en) | 1986-09-03 | 1986-09-03 | Process for preparing a pyrazolidine derivative |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO95505B1 (en) |
-
1986
- 1986-09-03 RO RO124678A patent/RO95505B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO95505B1 (en) | 1988-10-02 |
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