RO94454B - Process for preparing morphinan derivatives - Google Patents

Process for preparing morphinan derivatives

Info

Publication number
RO94454B
RO94454B RO123181A RO12318186A RO94454B RO 94454 B RO94454 B RO 94454B RO 123181 A RO123181 A RO 123181A RO 12318186 A RO12318186 A RO 12318186A RO 94454 B RO94454 B RO 94454B
Authority
RO
Romania
Prior art keywords
methyl
hydrogen
formula
hydroxy
general formula
Prior art date
Application number
RO123181A
Other languages
Romanian (ro)
Other versions
RO94454A (en
Inventor
Hosztafi Sandor
Makleit Sandor
Szilagyi Laszlo
Zsupan Kalman
Original Assignee
Alkaloida Vegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkaloida Vegyeszeti Gyar filed Critical Alkaloida Vegyeszeti Gyar
Priority to RO123181A priority Critical patent/RO94454B/en
Publication of RO94454A publication Critical patent/RO94454A/en
Publication of RO94454B publication Critical patent/RO94454B/en

Links

Landscapes

  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de morfinan cu formula generala I (vezi formula în pag.1 a descrierii) în care Z reprezinta o grupa -CH2-CH2- sau -CH-CH-, R1 reprezinta metil sau 2-propenil, R2 reprezinta hidrogen sau hidroxi, R3 reprezinta hidrogen sau metil, Y reprezinta -NH2, -NH-CONH2, -NH-CSNH2, -NHC6H5, -NH-C6H3(NO2)2, linia fragmentata reprezinta o legatura facultativa, cu conditia ca atunci cînd Z este -CH2-CH2-, R2 este hidroxi si R3 este hidrogen, Y sa nu fie -NH2; cînd Z este -CH2-CH2-, R1 este metil, R2 este hidrogen si R3 este metil, Y sa nu fie -NH2, -NHC6H5, -NH-C6H3(NO2)2 si -NH-CONH2; cînd Z este -CH-CH, R1 este metil, R2 este hidrogen, R3 este metil, Y sa nu fie -NH2; cînd R1 este metil, R2 si R3 sînt hidrogen, în pozitia 4 este o grupa hidroxil, Y sa nu fie -NH-CSNH2, prin tratarea unui derivat cetonic de morfinan cu formula generala similara, dar în care, în locul grupei =N-Y, este un atom de oxigen, cu o amina cu formula NH2Y.The invention relates to a process for the preparation of morphinane derivatives of general formula I (see formula on page 1 of the description) wherein Z represents a group -CH2-CH2- or -CH-CH-, R1 represents methyl or 2- propynyl, R2 represents hydrogen or hydroxy, R3 represents hydrogen or methyl, Y represents -NH2, -NH-CONH2, -NH-CSNH2, -NHC6H5, -NH-C6H3 (NO2) 2, the broken line represents a optional link, as when Z is -CH 2 -CH 2 -, R 2 is hydroxy and R 3 is hydrogen, Y is not -NH 2; when Z is -CH 2 -CH 2 -, R 1 is methyl, R 2 is hydrogen and R 3 is methyl, Y is not -NH 2, -NHC 6 H 5, -NH-C 6 H 3 (NO 2) 2 and -NH-CONH 2; when Z is -CH-CH, R1 is methyl, R2 is hydrogen, R3 is methyl, Y is not -NH2; when R 1 is methyl, R 2 and R 3 are hydrogen, in the 4-position it is a hydroxyl group, Y is not -NH-CSNH 2, by treatment of a morphine ketone derivative of the same general formula, but wherein instead of = NY, is an oxygen atom with an amine of formula NH2 Y.

RO123181A 1986-04-28 1986-04-28 Process for preparing morphinan derivatives RO94454B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RO123181A RO94454B (en) 1986-04-28 1986-04-28 Process for preparing morphinan derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO123181A RO94454B (en) 1986-04-28 1986-04-28 Process for preparing morphinan derivatives

Publications (2)

Publication Number Publication Date
RO94454A RO94454A (en) 1988-06-30
RO94454B true RO94454B (en) 1988-07-01

Family

ID=20119338

Family Applications (1)

Application Number Title Priority Date Filing Date
RO123181A RO94454B (en) 1986-04-28 1986-04-28 Process for preparing morphinan derivatives

Country Status (1)

Country Link
RO (1) RO94454B (en)

Also Published As

Publication number Publication date
RO94454A (en) 1988-06-30

Similar Documents

Publication Publication Date Title
MX9800867A (en) Halobenzimidazoles and their use as microbicides.
DE69722027D1 (en) CRYSTALS OF BENZIMIDAZOLE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
ES8707223A1 (en) Benzothiazole and benzothiophene derivatives.
PL257486A1 (en) Method of obtaining novel derivatives of arylocyclobutylalkylamine
HUT38358A (en) Process for producing ceph-3-eme derivatives
ES2040248T3 (en) PREPARATION METHOD OF INOSOSA DERIVATIVES.
YU46675B (en) PROCESS FOR PREPARATION OF 1- (HYDROC-SISTIROL) -5H-2,3-BENZODIAZEPINE DERIVATIVES
MY101142A (en) 1, 4-dihydropyridine derivative, process for production thereof, and pharmaceutical use thereof.
HUP0100453A1 (en) Method for producing isoureas
KR870005991A (en) Method for preparing amide derivative
ATE108760T1 (en) FLUORAPHTHACENDIONES, THEIR GLYCOSILATED DERIVATIVES AND PROCESSES FOR THEIR PREPARATION.
KR890014536A (en) Condensed quinoline compounds, condensed acridine compounds, methods for preparing the same, and anticancer compositions containing the same
HUP9903806A2 (en) A process for the biotransformation of colchicionid compounds into the corresponding 3-glycosyl derivatives
KR850005433A (en) Method for preparing naphthyridine and pyridopyrimidine compounds
DE3770359D1 (en) 6-AMINO-ANTHRACYCLINE, METHOD FOR THEIR PRODUCTION AND THEIR USE.
PT83816B (en) PROCESS FOR THE PREPARATION OF CEFALOSPORIN DERIVATIVES
ATE42295T1 (en) PENEM DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, THEIR USE AND PHARMACEUTICAL COMPOSITIONS.
ATE102955T1 (en) CYCLIC TETRAPEPTIDE AND PROCESS FOR PRODUCTION THEREOF.
DE68924010D1 (en) Process for the preparation of 1-alpha, 3-beta, 24-trihydroxy-delta-5 steroid derivatives.
RO65263B (en) Process for the preparation of 6-aza-benzodiazepine derivatives
EP0367671A3 (en) Novel beta-d-phenylthioxylosides, their method of preparation and their use as pharmaceuticals
RO72834B (en) Process for preparing derivatives of (5-alkylureido-1,3,4-thiadiazol-2-yl-sulphonyl)-acetic acids
KR910011863A (en) Synerzistin derivatives, methods for their preparation and use thereof
BG41127A3 (en) Method for preparing 1, 4- dihydropyridine derivatives
RO91141B (en) Process for the preparation of 2-oxindol-1-carboxamide derivatives