RO91673B1 - Procedeu de obtinere a 11-(3'-dimetilaminopropil)-11-hidrixi-6h-dibenzo (b, e) oxepinei - Google Patents
Procedeu de obtinere a 11-(3'-dimetilaminopropil)-11-hidrixi-6h-dibenzo (b, e) oxepineiInfo
- Publication number
- RO91673B1 RO91673B1 RO118118A RO11811885A RO91673B1 RO 91673 B1 RO91673 B1 RO 91673B1 RO 118118 A RO118118 A RO 118118A RO 11811885 A RO11811885 A RO 11811885A RO 91673 B1 RO91673 B1 RO 91673B1
- Authority
- RO
- Romania
- Prior art keywords
- dibenzo
- dimethylaminopropyl
- hydroxy
- oxepin
- obtaining
- Prior art date
Links
- ZEKLFUWSVQYTOO-UHFFFAOYSA-N 11-[3-(dimethylamino)propyl]-6h-benzo[c][1]benzoxepin-11-ol Chemical compound C1OC2=CC=CC=C2C(CCCN(C)C)(O)C2=CC=CC=C21 ZEKLFUWSVQYTOO-UHFFFAOYSA-N 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- -1 (3'-dimethylaminopropyl) -11-hydroxy-6H-dibenzo (b, e) oxepine Chemical compound 0.000 abstract 1
- 238000003747 Grignard reaction Methods 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 abstract 1
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 abstract 1
- 229960005426 doxepin Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la obtinerea a 11(3'-dimetil-aminopropil)-11-hidroxi-6H-dibenzo (b,e) oxepinei, intermediar în sinteza Doxepinului, printr-o reactie Grignard dintre dibenzo (b,e) oxepin-11-(6H)-ona si 1,3-clordimetilaminopropan într-o singura etapa în mediu de hidrocarbura aromatica (benzen, toluen) tetrahidrofuranul fiind utilizat în cantitati stoichiometrice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO118118A RO91673B1 (ro) | 1985-03-25 | 1985-03-25 | Procedeu de obtinere a 11-(3'-dimetilaminopropil)-11-hidrixi-6h-dibenzo (b, e) oxepinei |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO118118A RO91673B1 (ro) | 1985-03-25 | 1985-03-25 | Procedeu de obtinere a 11-(3'-dimetilaminopropil)-11-hidrixi-6h-dibenzo (b, e) oxepinei |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO91673A2 RO91673A2 (ro) | 1987-07-30 |
| RO91673B1 true RO91673B1 (ro) | 1987-07-31 |
Family
ID=20116835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO118118A RO91673B1 (ro) | 1985-03-25 | 1985-03-25 | Procedeu de obtinere a 11-(3'-dimetilaminopropil)-11-hidrixi-6h-dibenzo (b, e) oxepinei |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO91673B1 (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112079809B (zh) * | 2020-10-19 | 2021-07-13 | 武汉爱民制药股份有限公司 | 一种盐酸多塞平的合成方法 |
-
1985
- 1985-03-25 RO RO118118A patent/RO91673B1/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO91673A2 (ro) | 1987-07-30 |
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