RO91017B - Process for preparing purified 6-fluoro-4-chromanone - Google Patents

Process for preparing purified 6-fluoro-4-chromanone

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Publication number
RO91017B
RO91017B RO117308A RO11730883A RO91017B RO 91017 B RO91017 B RO 91017B RO 117308 A RO117308 A RO 117308A RO 11730883 A RO11730883 A RO 11730883A RO 91017 B RO91017 B RO 91017B
Authority
RO
Romania
Prior art keywords
fluoro
chromanone
amino acid
purified
aqueous
Prior art date
Application number
RO117308A
Other languages
Romanian (ro)
Other versions
RO91017A (en
Inventor
Cue Wendell Berkeley Jr.
Philip Dietrich Hammen
Sargent Massett Stephen
Bernard Shields Moore
John Sysko Robert
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Priority to RO117308A priority Critical patent/RO91017B/en
Publication of RO91017A publication Critical patent/RO91017A/en
Publication of RO91017B publication Critical patent/RO91017B/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la un procedeu pentru regenerarea 6-fluor-4-cromanonei purificate din R sau dintr-un amestec de R si RS-6-fluor-4-ureidocroman-4-corboxilic, sau din sarurile cationice ale acestora cu o amina optic acriva de exemplu. L(+)-1-feniletilamina sau L(-)-efedrina prin hidroliza în prezenta unei baze organice pentru a forma un minoacid intermediar, urmata de degradarea acestui aminoacid intermediar, urmata de degradarea acestui aminoacid intermediar într-un solvent apos cu un agent de clorurare si în final hidrogenarea acestui amestec de 6-fluor-4-cromanona si 6-fluor cu ajutorulunui metal nobil drept catalizator într-un solvent apos sau organic apos, pentru a obtine 6-fluor-4-cromanona purificata.The invention relates to a process for the regeneration of the purified 6-fluoro-4-chromanone from R or a mixture of R and RS-6-fluoro-4-ureidochroman-4-carboxylic acid, or their cationic salts with an optical amine acriva for example. L (+) - 1-phenylethylamine or L (-) - ephedrine by hydrolysis in the presence of an organic base to form an intermediate amino acid followed by degradation of this intermediate amino acid followed by degradation of this intermediate amino acid in an aqueous solvent with an agent chlorination and finally hydrogenation of this mixture of 6-fluoro-4-chromanone and 6-fluoro with the noble metal as a catalyst in an aqueous or aqueous organic solvent to obtain the purified 6-fluoro-4-chromanone.

RO117308A 1983-11-15 1983-11-15 Process for preparing purified 6-fluoro-4-chromanone RO91017B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RO117308A RO91017B (en) 1983-11-15 1983-11-15 Process for preparing purified 6-fluoro-4-chromanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO117308A RO91017B (en) 1983-11-15 1983-11-15 Process for preparing purified 6-fluoro-4-chromanone

Publications (2)

Publication Number Publication Date
RO91017A RO91017A (en) 1987-02-27
RO91017B true RO91017B (en) 1987-02-28

Family

ID=20116379

Family Applications (1)

Application Number Title Priority Date Filing Date
RO117308A RO91017B (en) 1983-11-15 1983-11-15 Process for preparing purified 6-fluoro-4-chromanone

Country Status (1)

Country Link
RO (1) RO91017B (en)

Also Published As

Publication number Publication date
RO91017A (en) 1987-02-27

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