RO88915B - Process for the preparation of 1-ethyl-1,4-dihydro-4-oxo--quinoline-3-carboxylic and 1-ethyl-1, 4-dihydro-4-oxo-1, 8-naphtiridin-3-carboxylic acid derivatives - Google Patents

Process for the preparation of 1-ethyl-1,4-dihydro-4-oxo--quinoline-3-carboxylic and 1-ethyl-1, 4-dihydro-4-oxo-1, 8-naphtiridin-3-carboxylic acid derivatives

Info

Publication number
RO88915B
RO88915B RO115120A RO11512084A RO88915B RO 88915 B RO88915 B RO 88915B RO 115120 A RO115120 A RO 115120A RO 11512084 A RO11512084 A RO 11512084A RO 88915 B RO88915 B RO 88915B
Authority
RO
Romania
Prior art keywords
ethyl
dihydro
oxo
carboxylic acid
quinoline
Prior art date
Application number
RO115120A
Other languages
Romanian (ro)
Other versions
RO88915A (en
Inventor
Jose Esteve Soler
Original Assignee
Provesan Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provesan Sa filed Critical Provesan Sa
Publication of RO88915A publication Critical patent/RO88915A/en
Publication of RO88915B publication Critical patent/RO88915B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati ai acizilor 1-etil-1,4-dihidro-4-oxo-chinolin-3-carboxilic si 1-etil-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilic cu formula generala I: (vezi formula) în care X reprezinta un atom de carbon sau de azot si R reprezinta un atom de hidrogen sau de fluor, constând din aceea ca un compus cu formula generala II: (vezi formula) în careX si R au semnificaâiile de mai sus, se trateaza cu 2,5-dimetil oxitetrahidrofuran, în mediu de acid acetic, eventual în amestec cu dimetilformaldehida în proportie de 1:1, dupa care compusi transformati, daca se doreste, în saruri de metale alcaline sau alcalino-pamântoase, acceptabile fiziologic, prin procedee în sine cunoscute.The invention relates to a process for the preparation of 1-ethyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and 1-ethyl-1,4- naphthyridine-3-carboxylic acid of the general formula I wherein X represents a carbon or nitrogen atom and R represents a hydrogen or fluorine atom consisting of a compound of the general formula II: ) in which X and R have the above meanings are treated with 2,5-dimethyl oxytetrahydrofuran in acetic acid medium, optionally in admixture with dimethylformaldehyde in a ratio of 1: 1, after which the compounds are converted, if desired, into salts of alkaline or alkaline earth metals, physiologically acceptable, by processes known per se.

RO115120A 1983-07-06 1984-07-03 Process for the preparation of 1-ethyl-1,4-dihydro-4-oxo--quinoline-3-carboxylic and 1-ethyl-1, 4-dihydro-4-oxo-1, 8-naphtiridin-3-carboxylic acid derivatives RO88915B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8311250A FR2548664B1 (en) 1983-07-06 1983-07-06 7- (PYRROL-L-YL) DERIVATIVES OF L-ETHYL-1,4-DIHYDRO-4-OXOQUINOLEIN-3-CARBOXYLIC ACIDS AND L-ETHYL-1,4-DIHYDRO-4-OXO- (1,8-NAPHTYRIDINE) ) -3-SUBSTITUTED CARBOXYLICS, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS

Publications (2)

Publication Number Publication Date
RO88915A RO88915A (en) 1987-06-30
RO88915B true RO88915B (en) 1987-07-01

Family

ID=9290571

Family Applications (1)

Application Number Title Priority Date Filing Date
RO115120A RO88915B (en) 1983-07-06 1984-07-03 Process for the preparation of 1-ethyl-1,4-dihydro-4-oxo--quinoline-3-carboxylic and 1-ethyl-1, 4-dihydro-4-oxo-1, 8-naphtiridin-3-carboxylic acid derivatives

Country Status (6)

Country Link
JP (1) JPS6036482A (en)
FR (1) FR2548664B1 (en)
IN (1) IN161611B (en)
RO (1) RO88915B (en)
SU (1) SU1322980A3 (en)
ZA (1) ZA844693B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1221492B (en) * 1984-03-13 1990-07-06 Biochem Design Srl ACIDS 7- (1-PIRRIL) -E 7- (1-PIRROLI-DINIL) -6-FLUORO-1-ETHYL-1,4-DIIDRO-4-KETOCHINOLIN-3-CARBOXYLS WITH ANTI-MICROBIAL ACTIVITIES, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOUNDS THAT CONTAIN THEM
US6080756A (en) * 1995-08-29 2000-06-27 Pfizer Inc. Polymorphs of the prodrug 6-N-(L-ALA-L-ALA)-trovafloxacin
DK0992501T3 (en) * 1995-09-22 2002-10-28 Wakunaga Pharma Co Ltd Pyridonecarboxylic acid derivatives as antibacterial agents
SK286420B6 (en) * 1997-09-15 2008-09-05 The Procter & Gamble Company Derivative of quinolone structure, pharmaceutical composition comprising the same and their use
AU3192700A (en) 1999-03-17 2000-10-04 Daiichi Pharmaceutical Co., Ltd. Medicinal compositions
MXPA02000103A (en) * 1999-07-01 2003-07-21 Wakunaga Pharma Co Ltd Quinolinecarboxylic acid derivative or salts thereof.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1006521A (en) * 1972-12-18 1977-03-08 Minoru Sugita Piperazine derivatives and process for preparing them
JPS5233694A (en) * 1975-09-09 1977-03-14 Dai Ichi Seiyaku Co Ltd Process for preparation of 6_nitro-1,8-naphthyridine derivatives
AR223983A1 (en) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co A PROCEDURE FOR PREPARING 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDIN-3-CARBOXYLIC ACID DERIVATIVES

Also Published As

Publication number Publication date
ZA844693B (en) 1985-02-27
JPS6036482A (en) 1985-02-25
RO88915A (en) 1987-06-30
IN161611B (en) 1988-01-02
FR2548664A1 (en) 1985-01-11
SU1322980A3 (en) 1987-07-07
FR2548664B1 (en) 1986-03-21
JPH026756B2 (en) 1990-02-13

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