RO87724B1 - Procedeu de obtinere a esculinei pure din cortex aesculus hyppocastanum - Google Patents
Procedeu de obtinere a esculinei pure din cortex aesculus hyppocastanumInfo
- Publication number
- RO87724B1 RO87724B1 RO113020A RO11302083A RO87724B1 RO 87724 B1 RO87724 B1 RO 87724B1 RO 113020 A RO113020 A RO 113020A RO 11302083 A RO11302083 A RO 11302083A RO 87724 B1 RO87724 B1 RO 87724B1
- Authority
- RO
- Romania
- Prior art keywords
- residue
- cortex
- dry
- pure
- concentrated
- Prior art date
Links
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 title abstract 2
- 241000157282 Aesculus Species 0.000 title abstract 2
- XHCADAYNFIFUHF-TVKJYDDYSA-N esculin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1OC(=O)C=C2 XHCADAYNFIFUHF-TVKJYDDYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 239000002994 raw material Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 235000013698 Brabejum stellatifolium Nutrition 0.000 abstract 1
- WNBCMONIPIJTSB-BGNCJLHMSA-N Cichoriin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1)c1c(O)cc2c(OC(=O)C=C2)c1 WNBCMONIPIJTSB-BGNCJLHMSA-N 0.000 abstract 1
- 244000237334 Pachira insignis Species 0.000 abstract 1
- 235000006562 Pachira insignis Nutrition 0.000 abstract 1
- 239000012675 alcoholic extract Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 229930182483 coumarin glycoside Natural products 0.000 abstract 1
- 150000008140 coumarin glycosides Chemical class 0.000 abstract 1
- 229940093496 esculin Drugs 0.000 abstract 1
- AWRMZKLXZLNBBK-UHFFFAOYSA-N esculin Natural products OC1OC(COc2cc3C=CC(=O)Oc3cc2O)C(O)C(O)C1O AWRMZKLXZLNBBK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000004519 grease Substances 0.000 abstract 1
- 238000002803 maceration Methods 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Inventia se refera la un procedeu de obtinere a esculinei pure din Cortex Aesculus hyppocastanum prin extractie, concentrare si recristalizare (scoarta de castan salbatic), condtînd din aceea ca materia prima vegetala uscata si pulverizata se extrage prin macerare, în doua etape succesive, la temperatura ambianta, cu acetona apoasa 40...60% în cantitate de 20 l la 1 kg materie prima, extractele reunite se concentreaza sub vid pîna la reziduu uscat, continînd totalul brut de glicozide cumarinice, acesta se extrage timp de 1 h sub reflux cu un alcanol inferior, în cantitate de 2,5-3 l la 200-250 g reziduu, extractul alcoolic se concentreaza pîna la reziduu uscat, care se recristalizeaza din amestec de metanol-apa 9:1 în volume, în cantitate de 3...5 l solvent la 100-150 g reziduu, produsul recristalizat se dizolva în 10-12 l apa la 100 g produs la temperatura de 90-95 degree C si dupa racire la temperatura camerei si mentinerea masei cristaline timp de 24 h la 5-10 degree C se obtine esculina pura cu un continut de 94-96%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO113020A RO87724B1 (ro) | 1983-12-23 | 1983-12-23 | Procedeu de obtinere a esculinei pure din cortex aesculus hyppocastanum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO113020A RO87724B1 (ro) | 1983-12-23 | 1983-12-23 | Procedeu de obtinere a esculinei pure din cortex aesculus hyppocastanum |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO87724A2 RO87724A2 (ro) | 1985-12-30 |
| RO87724B1 true RO87724B1 (ro) | 1985-12-31 |
Family
ID=20114102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO113020A RO87724B1 (ro) | 1983-12-23 | 1983-12-23 | Procedeu de obtinere a esculinei pure din cortex aesculus hyppocastanum |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO87724B1 (ro) |
-
1983
- 1983-12-23 RO RO113020A patent/RO87724B1/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO87724A2 (ro) | 1985-12-30 |
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