RO86594B1 - Derivat -o- substituit al 1-metil-2-hidroximetil-5-nitroimidazolului si procedeu de preparare a acestuia - Google Patents
Derivat -o- substituit al 1-metil-2-hidroximetil-5-nitroimidazolului si procedeu de preparare a acestuiaInfo
- Publication number
- RO86594B1 RO86594B1 RO110749A RO11074983A RO86594B1 RO 86594 B1 RO86594 B1 RO 86594B1 RO 110749 A RO110749 A RO 110749A RO 11074983 A RO11074983 A RO 11074983A RO 86594 B1 RO86594 B1 RO 86594B1
- Authority
- RO
- Romania
- Prior art keywords
- methyl
- nitroimidazole
- hydroxymethyl
- nitroimidazol
- methyle
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- JSAQDPJIVQMBAY-UHFFFAOYSA-N (1-methyl-5-nitroimidazol-2-yl)methanol Chemical class CN1C(CO)=NC=C1[N+]([O-])=O JSAQDPJIVQMBAY-UHFFFAOYSA-N 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 238000010992 reflux Methods 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- -1 1-methyl-2-aminooxymethyl-5-nitroimidazole dihydrochloride Chemical compound 0.000 abstract 1
- PDISGXFXQFGQFB-UHFFFAOYSA-N 2-(chloromethyl)-1-methyl-5-nitroimidazole Chemical compound CN1C(CCl)=NC=C1[N+]([O-])=O PDISGXFXQFGQFB-UHFFFAOYSA-N 0.000 abstract 1
- CFMZSMGAMPBRBE-UHFFFAOYSA-N 2-hydroxyisoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(O)C(=O)C2=C1 CFMZSMGAMPBRBE-UHFFFAOYSA-N 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Inventia de fata se refera la un derivat 0-substituit al 1-metil-2-hidroximetil-5-nitroimidazolului, care este 1-metil-2-aminooximetil-5-nitroimidazol diclorhidrat cu formula generala I: (vezi formula) produs cristalin, alb, cu punct de topire 168-171 degree C. Procedeul pentru obtinerea acestui produs consta în tratarea 1-metil-2-hidroximetil-5-nitroimidazolului cu clorura de tionil, în benzen la temperatura de reflux, condensarea 1-metil-2-clormetil-5-nitroimidazolului obtinut in situ cu N-hidroxiftalimida în dimetilformamida la temperatura de 90-95 degree C, urmata de tratarea 1-metil-2-(ftalimido-N-oximetil)-5-nitroimidazolului obtinut cu hidrazina în metanol la temperatura de reflux si precipitare cu solutie apoasa de HCl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO110749A RO86594B1 (ro) | 1983-04-22 | 1983-04-22 | Derivat -o- substituit al 1-metil-2-hidroximetil-5-nitroimidazolului si procedeu de preparare a acestuia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO110749A RO86594B1 (ro) | 1983-04-22 | 1983-04-22 | Derivat -o- substituit al 1-metil-2-hidroximetil-5-nitroimidazolului si procedeu de preparare a acestuia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO86594A2 RO86594A2 (ro) | 1985-04-17 |
| RO86594B1 true RO86594B1 (ro) | 1985-05-01 |
Family
ID=20112978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO110749A RO86594B1 (ro) | 1983-04-22 | 1983-04-22 | Derivat -o- substituit al 1-metil-2-hidroximetil-5-nitroimidazolului si procedeu de preparare a acestuia |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO86594B1 (ro) |
-
1983
- 1983-04-22 RO RO110749A patent/RO86594B1/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO86594A2 (ro) | 1985-04-17 |
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