RO83972B - Process for preparing oxazaphospharin derivatives - Google Patents

Process for preparing oxazaphospharin derivatives

Info

Publication number
RO83972B
RO83972B RO105257A RO10525781A RO83972B RO 83972 B RO83972 B RO 83972B RO 105257 A RO105257 A RO 105257A RO 10525781 A RO10525781 A RO 10525781A RO 83972 B RO83972 B RO 83972B
Authority
RO
Romania
Prior art keywords
represents hydrogen
chloroethyl
fluorophenyl
methyl
derivatives
Prior art date
Application number
RO105257A
Other languages
Romanian (ro)
Other versions
RO83972A (en
Inventor
Gerhard Scheffler
Ulf Niemeyer
Norbert Brock
Jorg Pohl
Original Assignee
Asta-Werke-Aktiengesellschaft Chemische Fabrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta-Werke-Aktiengesellschaft Chemische Fabrik filed Critical Asta-Werke-Aktiengesellschaft Chemische Fabrik
Publication of RO83972A publication Critical patent/RO83972A/en
Publication of RO83972B publication Critical patent/RO83972B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Procedeul de preparare a derivatilor de oxazafosforine cu formula generala I: (vezi formula) în care R1 reprezinta cloretil, metansulfoniloxietil, R2 reprezinta hidrogen, metil, cloretil, R3 reprezinta hidrogen, clor-etil, metansulfoniloximetil, R4 reprezinta hidrogen, metil, Z reprezinta grupa (vezi formula) în care R5 reprezinta hidrogen, metil sau etil sau împreuna cu R6 formeaza radicalul morfolino, tiomorfolino sau piperidino, R6 reprezinta hidrogen, alchil C1-C14, ciclohexil, clor-etil, brompropil, 2-etoxicarboniletil, etoxicerbonilmetil, carboxietil, dimetilfosfonometil, alil, fenletil, 2-feniletil, difenilmetil, naftil, fenil, eventual, substituit cu Br, Cl, F, metil, metoxi, nitro,trifluormetil, cu doi atomi de clor, aminosulfonil, sau R6 este o grupa hidroxi, fenilcarbonil, aminocarbonil, 2-fluorfenil, aminocarbonil, 2-fluorfenil, 9-oxo-2-fluorfenil, benzil....The process for the preparation of oxazaphosphorin derivatives of general formula I: (wherein R 1 represents chloroethyl, methanesulfonyloxyethyl, R 2 represents hydrogen, methyl, chloroethyl, R 3 represents hydrogen, chloroethyl, methanesulfonyloxymethyl, R 4 represents hydrogen, methyl, Z represents R6 represents hydrogen, C1-C14 alkyl, cyclohexyl, chloro-ethyl, bromopropyl, 2-ethoxycarbonylethyl, ethoxycarbonylmethyl, carboxyethyl alkenyl, phenyl, 2-phenylethyl, diphenylmethyl, naphthyl, phenyl optionally substituted with Br, Cl, F, methyl, methoxy, nitro, trifluoromethyl with two chlorine atoms, aminosulfonyl or R6 is a hydroxy, phenylcarbonyl, aminocarbonyl, 2-fluorophenyl, aminocarbonyl, 2-fluorophenyl, 9-oxo-2-fluorophenyl, benzyl.

RO105257A 1980-09-10 1981-09-08 Process for preparing oxazaphospharin derivatives RO83972B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8029222 1980-09-10

Publications (2)

Publication Number Publication Date
RO83972A RO83972A (en) 1984-09-29
RO83972B true RO83972B (en) 1984-10-30

Family

ID=10515985

Family Applications (1)

Application Number Title Priority Date Filing Date
RO105257A RO83972B (en) 1980-09-10 1981-09-08 Process for preparing oxazaphospharin derivatives

Country Status (29)

Country Link
JP (1) JPS5785396A (en)
AR (1) AR231989A1 (en)
AT (1) AT386210B (en)
AU (1) AU538275B2 (en)
BE (1) BE890276A (en)
CA (2) CA1161453A (en)
CH (1) CH650787A5 (en)
CS (1) CS227680B2 (en)
DD (1) DD202166A5 (en)
DE (1) DE3133309A1 (en)
DK (1) DK400481A (en)
EG (1) EG15392A (en)
ES (1) ES505324A0 (en)
FI (1) FI70026C (en)
FR (1) FR2489825A1 (en)
GR (1) GR75300B (en)
HU (1) HU185953B (en)
IE (1) IE51784B1 (en)
IL (1) IL63661A (en)
IT (2) IT1198350B (en)
LU (1) LU83613A1 (en)
NL (1) NL8104093A (en)
NO (1) NO161261C (en)
PL (1) PL128627B1 (en)
PT (1) PT73645B (en)
RO (1) RO83972B (en)
SE (1) SE458203B (en)
YU (1) YU42584B (en)
ZA (1) ZA815922B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0158057B1 (en) * 1984-03-01 1989-04-26 ASTA Pharma AG Salts of oxazaphosphorine derivatives
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
WO2016089208A2 (en) 2014-12-04 2016-06-09 Stichting Maastricht Radiation Oncology "Maastro-Clinic" Sulfonamide, sulfamate and sulfamide derivatives of anti-cancer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA955937A (en) * 1971-06-28 1974-10-08 Shionogi And Co. Ltd. Cyclic phosphamide derivatives
US3911005A (en) * 1974-09-12 1975-10-07 Monsanto Co 1,3,2-Diazaphospholidine compounds
JPS5159886A (en) * 1974-11-20 1976-05-25 Shionogi Seiyaku Kk

Also Published As

Publication number Publication date
PT73645A (en) 1981-10-01
IL63661A (en) 1987-01-30
FI812798L (en) 1982-03-11
AU7465781A (en) 1982-03-18
NO161261B (en) 1989-04-17
CS227680B2 (en) 1984-05-14
IT1220985B (en) 1990-06-21
SE458203B (en) 1989-03-06
CA1161453A (en) 1984-01-31
DE3133309C2 (en) 1989-07-27
SE8105340L (en) 1982-03-11
IT1198350B (en) 1988-12-21
ES8206544A1 (en) 1982-08-16
YU42584B (en) 1988-10-31
YU217981A (en) 1983-12-31
IE811951L (en) 1982-03-10
ZA815922B (en) 1982-09-29
FI70026C (en) 1986-09-12
NO161261C (en) 1989-07-26
HU185953B (en) 1985-04-28
DK400481A (en) 1982-03-11
NL8104093A (en) 1982-04-01
ES505324A0 (en) 1982-08-16
IL63661A0 (en) 1981-11-30
FR2489825B1 (en) 1984-11-23
AU538275B2 (en) 1984-08-09
CH650787A5 (en) 1985-08-15
PL232960A1 (en) 1982-04-26
NO813063L (en) 1982-03-11
LU83613A1 (en) 1982-01-21
AT386210B (en) 1988-07-25
IT8123860A0 (en) 1981-09-09
JPH029599B2 (en) 1990-03-02
PT73645B (en) 1986-03-21
AR231989A1 (en) 1985-04-30
IE51784B1 (en) 1987-04-01
DD202166A5 (en) 1983-08-31
PL128627B1 (en) 1984-02-29
CA1184563B (en) 1985-03-26
DE3133309A1 (en) 1982-04-15
ATA386481A (en) 1987-12-15
JPS5785396A (en) 1982-05-28
FI70026B (en) 1986-01-31
RO83972A (en) 1984-09-29
BE890276A (en) 1982-01-04
GR75300B (en) 1984-07-13
FR2489825A1 (en) 1982-03-12
EG15392A (en) 1985-12-31
IT8421372A0 (en) 1984-06-12

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