RO81033B1 - Progesterone-albumin conjugate and process for preparing the same - Google Patents
Progesterone-albumin conjugate and process for preparing the sameInfo
- Publication number
- RO81033B1 RO81033B1 RO101151A RO10115180A RO81033B1 RO 81033 B1 RO81033 B1 RO 81033B1 RO 101151 A RO101151 A RO 101151A RO 10115180 A RO10115180 A RO 10115180A RO 81033 B1 RO81033 B1 RO 81033B1
- Authority
- RO
- Romania
- Prior art keywords
- progesterone
- weight ratio
- cysteine
- preparing
- treated
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 4
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229960003387 progesterone Drugs 0.000 abstract 2
- 239000000186 progesterone Substances 0.000 abstract 2
- HFSZYSZYZVKKOX-UHPWKVKZSA-N (8s,9s,10r,13s,14s,17s)-17-acetyl-6-bromo-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical compound C1C(Br)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 HFSZYSZYZVKKOX-UHPWKVKZSA-N 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 abstract 1
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229940098773 bovine serum albumin Drugs 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 abstract 1
- 239000002953 phosphate buffered saline Substances 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
Abstract
Conjugat progesteron albuminic, caracterizat prin aceea ca are formula: (vezi formula) cu aspect cristalin, galben pal si cu masa moleculara 78000...80000 daltoni, care se trateaza progesterona cu bromsuccinimida în raport în greutate de circa 1,66:1 la temperatura de reflux a amestecului, obtinîndu-se 6-Br-progesteron, care este tratat cu cisteina, la o solutie alcoolica la pH circa 8 si temperatura mediului ambiant a camerei folosind un raport în greutate între reactantii de circa 3,1:1, iar produsul de reactie constînd din progesteron-6-S-L-cisteina este tratat cu albumina serica de bovina în raport în greutate de circa 1:10, la temperatura camerei în prezenta de 1-ciclohexil-3-(2-morfoli-4-etil)-carbodiimida, cu rol de utilizator, folosind ca mediu de reactie tampon fosfat salin la pH=7,4 apoi produsul de reactie este separat din amestec, în mod cunoscut.The albumin progesterone conjugate, characterized in that it has the form of a pale pale yellow crystalline aspect and a molecular weight of 78,000 ... 80000 daltons, which treats progesterone with bromosuccinimide in a weight ratio of about 1.66: 1 to the reflux temperature of the mixture yielding 6-Br-progesterone which is treated with cysteine at an alcoholic solution at about pH 8 and room temperature using a weight ratio of reactants of about 3.1: 1, and the reaction product consisting of progesterone-6-SL-cysteine is treated with bovine serum albumin in a weight ratio of about 1:10 at room temperature in the presence of 1-cyclohexyl-3- (2-morphol-4-ethyl ) -carbodiimide as the user, using phosphate buffered saline at pH = 7.4, then the reaction product is separated from the mixture in the known manner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO80101151A RO81033A2 (en) | 1980-05-17 | 1980-05-17 | PROGESTERONE-ALBUMINIC ADJUSTER AND PREPARATION PROCESS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO80101151A RO81033A2 (en) | 1980-05-17 | 1980-05-17 | PROGESTERONE-ALBUMINIC ADJUSTER AND PREPARATION PROCESS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO81033B1 true RO81033B1 (en) | 1983-01-30 |
| RO81033A2 RO81033A2 (en) | 1983-02-01 |
Family
ID=20108526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO80101151A RO81033A2 (en) | 1980-05-17 | 1980-05-17 | PROGESTERONE-ALBUMINIC ADJUSTER AND PREPARATION PROCESS |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO81033A2 (en) |
-
1980
- 1980-05-17 RO RO80101151A patent/RO81033A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO81033A2 (en) | 1983-02-01 |
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