RO135144A1 - Process for preparing a skin-bioregenerating ointment - Google Patents
Process for preparing a skin-bioregenerating ointment Download PDFInfo
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- RO135144A1 RO135144A1 RO202000060A RO202000060A RO135144A1 RO 135144 A1 RO135144 A1 RO 135144A1 RO 202000060 A RO202000060 A RO 202000060A RO 202000060 A RO202000060 A RO 202000060A RO 135144 A1 RO135144 A1 RO 135144A1
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- 239000002674 ointment Substances 0.000 title claims abstract description 23
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract description 15
- 244000042664 Matricaria chamomilla Species 0.000 claims abstract description 8
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims abstract description 8
- 235000017309 Hypericum perforatum Nutrition 0.000 claims abstract description 7
- 244000141009 Hypericum perforatum Species 0.000 claims abstract description 7
- 240000001432 Calendula officinalis Species 0.000 claims abstract description 5
- 235000005881 Calendula officinalis Nutrition 0.000 claims abstract description 5
- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 5
- 235000019486 Sunflower oil Nutrition 0.000 claims abstract description 4
- 235000013871 bee wax Nutrition 0.000 claims abstract description 4
- 239000012166 beeswax Substances 0.000 claims abstract description 4
- 238000009835 boiling Methods 0.000 claims abstract description 4
- 239000002600 sunflower oil Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000013543 active substance Substances 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 6
- 244000246386 Mentha pulegium Species 0.000 claims description 4
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 4
- 235000001050 hortel pimenta Nutrition 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 3
- 240000000073 Achillea millefolium Species 0.000 abstract 1
- 235000007754 Achillea millefolium Nutrition 0.000 abstract 1
- 241001479543 Mentha x piperita Species 0.000 abstract 1
- 229940092738 beeswax Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000001771 mentha piperita Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000035876 healing Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 229930014626 natural product Natural products 0.000 description 4
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 235000012308 Tagetes Nutrition 0.000 description 2
- 241000736851 Tagetes Species 0.000 description 2
- 230000001430 anti-depressive effect Effects 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 229940005513 antidepressants Drugs 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 230000001989 choleretic effect Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 230000003836 peripheral circulation Effects 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- 239000001500 (2R)-6-methyl-2-[(1R)-4-methyl-1-cyclohex-3-enyl]hept-5-en-2-ol Substances 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 241000251730 Chondrichthyes Species 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 229920000715 Mucilage Polymers 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- -1 alkaloid compounds Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 description 1
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 1
- 229940117893 apigenin Drugs 0.000 description 1
- 235000008714 apigenin Nutrition 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 150000001765 catechin Chemical class 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 235000020346 chamomile tea Nutrition 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- 239000000731 choleretic agent Substances 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 150000004775 coumarins Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- IWBJJCOKGLUQIZ-HQKKAZOISA-N hyperforin Chemical compound OC1=C(CC=C(C)C)C(=O)[C@@]2(CC=C(C)C)C[C@H](CC=C(C)C)[C@](CCC=C(C)C)(C)[C@]1(C(=O)C(C)C)C2=O IWBJJCOKGLUQIZ-HQKKAZOISA-N 0.000 description 1
- QOVWXXKVLJOKNW-UHFFFAOYSA-N hyperforin Natural products CC(C)C(=O)C12CC(CC=C(C)C)(CC(CC=C(C)C)C1CCC=C(C)C)C(=C(CC=C(C)C)C2=O)O QOVWXXKVLJOKNW-UHFFFAOYSA-N 0.000 description 1
- PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 description 1
- BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 description 1
- 229940005608 hypericin Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical group CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
OFICIUL DE STATA1 Cerere de brevet de invențieSTATE OFFICE1 Patent application
Nr. CpNr. Cp
Data depozit......Ι.θDate of deposit ...... Ι.θ
PROCEDEU DE OBȚINERE r ——........PROCESS FOR OBTAINING r ——........
A UNUI UNGUENT BIOREGENERANT PENTRU PIELEOF A BIOREGENERATING SKIN OINTMENT
Invenția se referă la un procedeu de obținere a unui unguent pe bază de plante medicinale, cu calități bioregenerante, eficient în tratarea țesuturilor afectate de răni, crăpături și arsuri. Procedeul este foarte versatil, fiind la îndemâna oricui, putând fi utilizat atât în uz gospodăresc, cât și la nivel instituțional, de către farmacii, spitale, întreprinderi farmaceutice, întreprinderi producătoare de produse cosmetic etc.The invention relates to a process for obtaining an ointment based on medicinal plants, with bioregenerating qualities, effective in treating tissues affected by wounds, cracks and burns. The process is very versatile, being available to anyone, and can be used both in household use and at the institutional level, by pharmacies, hospitals, pharmaceutical companies, companies producing cosmetics, etc.
Este cunoscut faptul că există o tendință în domeniul medical de a utiliza tratamente și terapii non-invazive care să fie eficiente în vindecarea diferitelor afecțiuni ale țesutului epitelial extern, fără a produce efecte secundare nocive organismului uman. Cele mai dificile probleme pe care le întâmpină personalul medical dar și persoanele private sunt cele cauzate de arsuri. Este binecunoscută dificultatea de a vindeca arsuri în condiții aseptice astfel încât să poată fi redus la minimum riscul de infecție și timpul de vindecare.It is known that there is a tendency in the medical field to use non-invasive treatments and therapies that are effective in curing various diseases of the external epithelial tissue, without producing harmful side effects to the human body. The most difficult problems that medical staff and private individuals face are those caused by burns. The difficulty of healing aseptic burns is well known so that the risk of infection and healing time can be minimized.
O problemă în plus este cea a obținerii unor produse pentru tratarea arsurilor pe bază de produse naturale și nu chimice.An additional problem is the obtaining of products for the treatment of burns based on natural products and not chemicals.
Se cunosc mai multe tipuri de alifii și unguente, pe bază de extracte din plante medicinale destinate vindecării țesuturilor afectate de arsuri.Several types of ointments and ointments are known, based on extracts from medicinal plants intended for the healing of tissues affected by burns.
Se cunoaște documentul de brevet nr. RO 108643, care se referă la un unguent pe bază de produse naturale, destinat tratamentului arsurilor superficiale și profunde. Un dezavantaj al acestui produs este faptul că utilizează pentru obținere și un produs chimic, și anume pulbere de bismut subgalic, care ar putea prezenta riscul de a fi respins de organismul uman sau chiar de a prezenta reacții alergice.Patent document no. RO 108643, which refers to an ointment based on natural products, intended for the treatment of superficial and deep burns. A disadvantage of this product is that it uses to obtain a chemical, namely subgalactic bismuth powder, which could present the risk of being rejected by the human body or even of allergic reactions.
Se mai cunoaște documentul de brevet nr. RO 121672, care se referă la un unguent pentru regenerarea și cicatrizarea plăgilor și arsurilor, Dezavantajul acestui unguent este faptul că și acesta se obține nu numai din produse naturale, la obținerea sa utilizându-se și un produs chimic, și anume tristearatul de gliceril, care este un triglicerid derivat din trei unități de acid stearic. Un alt dezavantaj al acestei soluții este faptul că necesită pentru preparare ficat de rechin, produs foarte scump și dificil de procurat, ceea ce conduce la creșterea costurilor pentru obținerea unguentului și, implicit un preț de vânzare ridicat, care îl face să nu fie la îndemâna oricui.Patent document no. EN 121672, which relates to an ointment for the regeneration and healing of wounds and burns, which is a triglyceride derived from three units of stearic acid. Another disadvantage of this solution is that it requires for the preparation of shark liver, a very expensive product and difficult to procure, which leads to increased costs for obtaining the ointment and, implicitly, a high selling price, which makes it out of reach. anyone.
Dezavantajele comune ambelor soluții cunoscute sunt: pe de o parte, ambele unguente necesită un timp îndelungat de acționare pentru a-și face efectul și a vindeca arsurile, iar pe de altă parte, prepararea lor nu este la îndemâna oricui, ele necesitând laboratoare și personal specializate.The common disadvantages of both known solutions are: on the one hand, both ointments require a long time of action to take effect and heal burns, and on the other hand, their preparation is not available to everyone, they require laboratories and staff. specialized.
DRĂGHICI FlorinaDRĂGHICI Florina
DRĂGHICI Laurențiu lonuțDRĂGHICI Laurențiu lonuț
RO 135144 Α1RO 135144 Α1
Problema tehnică pe care o rezolvă invenția constă în realizarea unui procedeu simplu de obținere a unui unguent bioregenerant pentru țesuturile epiteliale afectate de răni, crăpături sau arsuri, accesibil oricărei persoane, inclusiv acasă, procedeul presupunând utilizarea exclusiv a produselor naturale.The technical problem solved by the invention consists in carrying out a simple process for obtaining a bioregenerating ointment for epithelial tissues affected by wounds, cracks or burns, accessible to any person, including at home, the process involving the exclusive use of natural products.
Procedeul de obținere a unui unguent bioregenerant pentru piele, conform invenției revendicate rezolvă problema tehnică prin faptul că utilizează exclusiv produse naturale, și anume: Calendula officinalis (gălbenelele), Achilea millefolium (coada șoricelului), Matricaria chamomilla (mușețelul), Menta piperita (menta), Hypericum perforatum (Sunătoarea), care se adaugă în apă adusă la punctul de fierbere, ceară de albine și ulei de floarea soarelui.The process for obtaining a bioregenerating skin ointment according to the claimed invention solves the technical problem by using only natural products, namely: Calendula officinalis (marigolds), Achilea millefolium (mouse tail), Matricaria chamomilla (chamomile), Peppermint ), Hypericum perforatum (St. John's wort), which is added to boiling water, beeswax and sunflower oil.
Calendula officinalis (Gălbenelele) prezintă în compoziția lor substanțe active, precum uleiul volatil, substanțele amare, substanțele tri-terpenice, rezinele, carotenoidele, flavonoizii, saponinele, taninul, rășinile și mucilagiile ale căror efecte confirmate de medicina alopată au acțiune emenagogă, antispastică, coleretică, antiseptică, cicatrizantă, antiinflamatoare și de activare a circulației periferice.Calendula officinalis (Marigolds) contains in their composition active substances, such as volatile oil, bitter substances, tri-terpenic substances, resins, carotenoids, flavonoids, saponins, tannin, resins and mucilages whose effects confirmed by allopathic medicine have emastic antisense action, choleretic, antiseptic, healing, anti-inflammatory and activating peripheral circulation.
Achilea millefolium (Coada șoricelului), prin complexul protein-carbohidrați existent în flori are o acțiune antiinflamatorie, iar compușii alcaloidici determină efecte antipiretice, antibacteriene, coleretice.Achilea millefolium (Mouse's tail), through the protein-carbohydrate complex existing in flowers has an anti-inflammatory action, and alkaloid compounds cause antipyretic, antibacterial, choleretic effects.
Matricaria chamomilla (Mușețelul), pe lângă acidul salicilic, vitamina A, riboflavin și minerale cum ar fi calciu, fier, magneziu, potasiu, zinc, mangan, sodiu, mai conține flavonoizi, terpenoizi, cumarine și spiroeteri. Astfel, principalii compuși activi care se regăsesc în mușețel și anume alfa-bisabolol are rol antiinflamator, antibacterian, antiiritant si antialergic, camazulena are semnificative proprietăți inflamatorii, iar apigenina are rol în inhibarea activității de diviziune anormală a celulelor și proprietăți antivirale, antioxidante și antiinflamatoareMatricaria chamomilla (Chamomile), in addition to salicylic acid, vitamin A, riboflavin and minerals such as calcium, iron, magnesium, potassium, zinc, manganese, sodium, also contains flavonoids, terpenoids, coumarins and spiroethers. Thus, the main active compounds found in chamomile, namely alpha-bisabolol has an anti-inflammatory, antibacterial, anti-irritant and antiallergic role, camazulena has significant inflammatory properties, and apigenin has a role in inhibiting abnormal cell division activity and antiviral, antioxidant and anti-inflammatory properties.
Menta piperita (Menta), pe lângă vitaminele A si C, fier, potasiu, magneziu, calciu și fosfor, conține o cantitate importantă de antioxidanți, care contribuie la protejarea celulelor împotriva stresului oxidativ. Mentolul - principalul ingredient activ al mentei - are un efect antispasmodic relaxant.Peppermint (Mint), in addition to vitamins A and C, iron, potassium, magnesium, calcium and phosphorus, contains a significant amount of antioxidants, which help protect cells against oxidative stress. Menthol - the main active ingredient in mint - has a relaxing antispasmodic effect.
Hypericum perforatum (Sunătoarea) conține mai multe substanțe active printre care amintim hipericina, care s-a demonstrat că are proprietăți antiseptice, antivirale și antidepresive, hiperforina, cunoscută pentru proprietățile sale antidepresive, antibacteriene și calmante, flavonoidele, taninurile și catehina, care sunt active antioxidante cu rol important în apararea organismului, acidul clorogenic și uleiurile volatile, care au proprietăți calmante și antiinflamatoare și saponinele, cunoscute pentru calitățile lor antibacteriene.Hypericum perforatum (St. John's wort) contains several active substances including hypericin, which has been shown to have antiseptic, antiviral and antidepressant properties, hyperforin, known for its antidepressant, antibacterial and calming properties, flavonoids, tannins and catechins, which are active antioxidants important role in defending the body, chlorogenic acid and volatile oils, which have calming and anti-inflammatory properties and saponins, known for their antibacterial qualities.
DRĂGHICI FlorinaDRĂGHICI Florina
DRĂGHICI Laurențiu lonuțDRĂGHICI Laurențiu lonuț
RO 135144 Α1RO 135144 Α1
Această combinație de substanțe active din fitoplantele utilizate, dezvoltă proprietăți sinergice unguentului, care prin acțiunea delicată cu țesuturile afectate, reduce starea inflamatorie a acestora, calmează senzațiile dureroase, stimulează ușor circulația periferică și energizează schimbul intercelular favorizând regenerarea acestora.This combination of active substances from the phytoplants used, develops synergistic properties to the ointment, which through the delicate action with the affected tissues, reduces their inflammatory state, soothes painful sensations, slightly stimulates peripheral circulation and energizes intercellular exchange promoting their regeneration.
Procedeul de obținere a unui unguent bioregenerant pentru piele, conform invenției, prezintă următoarele avantaje:The process for obtaining a bioregenerating skin ointment according to the invention has the following advantages:
prin acțiunea substanțelor active ale fitoplantelor utilizate de procedeu se obține un efect antiinflamator, bioregenerant și cicatrizant, fiind astfel recomandat pentru arsuri de la cele superficiale până la cele de profunzime medie;by the action of the active substances of the phytoplants used by the process, an anti-inflammatory, bioregenerating and healing effect is obtained, being thus recommended for burns from superficial to medium depth ones;
unguentul obținut are efect emolient asupra pielii uscate și crăpate;the ointment obtained has an emollient effect on dry and cracked skin;
unguentul obținut are efect hidratant și stimulator al celulelor epiteliale datorită absorbției rapide în țesuturi;the ointment obtained has a moisturizing and stimulating effect on epithelial cells due to its rapid absorption into tissues;
unguentul obținut exercită o acțiune delicată asupra țesuturilor, fără a produce iritații;the ointment obtained exerts a delicate action on the tissues, without causing irritation;
din experiențele efectuate, unguentul obținut prin acest procedeu nu prezintă reacții adverse;from the experiments carried out, the ointment obtained by this process does not show side effects;
procedeul permite eliberarea substanțelor active ale plantelor aflate în compoziție si o utilizare îndelungată fără a fi necesari conservanți;the process allows the release of the active substances of the plants in the composition and a long use without the need for preservatives;
procedeul este simplu, utilizează ingrediente ușor de procurat și poate fi utilizat de către orice persoană, fără să fie necesară o pregătire specială și fără să necesite ustensile speciale pentru preparare.the process is simple, uses ingredients that are easy to procure and can be used by anyone, without the need for special training and without the need for special utensils for preparation.
Se prezintă, în continuare, un exemplu de realizare practică a procedeului de obținere a unguentului bioregenerant pentru piele: într-un recipient nemetalic, se aduce un litru de apă la temperatura de fierbere 100 °C, după care se adaugă 8-10 gr. Calendula officinalis, 5-7 gr. Achilea millefolium, 8-10 gr. Matricaria chamomilla, 9-10 gr. Menta piperita, 8-10 gr Hypericum perforatum și se mențin la temperatura de 100 °C timp de 10 minute. Soluția rezultată se lasă 30 de minute pentru a se elibera substanțele active din fitoplante. După acest interval de timp, se filtrează soluția printr-o sită fină nemetalică. La această soluție, se adaugă 15-25 gr.ceară de albine și 25-35 gr. ulei de floarea soarelui presat la rece, după care se aduce soluția la temperatura de 100° C și se menține timp de 10 minute. Se lasă la decantat 30 minute, după care se colectează de pe suprafața soluției substanțele ușor solidificate și se pun în recipiente de culoare închisă, care se închid ermetic.The following is an example of a practical embodiment of the process for obtaining bioregenerating skin ointment: in a non-metallic container, bring a liter of water to a boiling point of 100 ° C, then add 8-10 gr. Calendula officinalis, 5-7 gr. Achilea millefolium, 8-10 gr. Matricaria chamomilla, 9-10 gr. Peppermint, 8-10 gr Hypericum perforatum and keep at 100 ° C for 10 minutes. The resulting solution is left for 30 minutes to release the active substances from the phytoplants. After this time, filter the solution through a fine non-metallic sieve. To this solution, add 15-25 gr. Beeswax and 25-35 gr. cold-pressed sunflower oil, then bring the solution to a temperature of 100 ° C and hold for 10 minutes. Leave to settle for 30 minutes, then collect the slightly solidified substances from the surface of the solution and place them in dark containers, which are hermetically sealed.
Unguentul obținut prin procedeul conform invenției se utilizează prin aplicarea lui într-un strat subțire pe pansament, după care acesta se fixează cu ajutorul rolei de tifon pe țesutul afectat deThe ointment obtained by the process according to the invention is used by applying it in a thin layer on the dressing, after which it is fixed with the help of a gauze roll on the tissue affected by
DRĂGHICI FlorinaDRĂGHICI Florina
DRĂGHICI Laurențiu lonuțDRĂGHICI Laurențiu lonuț
RO 135144 Α1 arsuri, dezinfectat în prealabil cu ceai de mușețel. în cazul arsurilor de profunzime medie este recomandată schimbarea zilnică a pansamentului.RO 135144 Α1 burns, previously disinfected with chamomile tea. in the case of medium depth burns, a daily change of dressing is recommended.
în cazul tăieturilor, crăpăturilor și al zgârieturilor, unguentul se poate aplica direct pe zona afectată prin masare ușoară, pentru a favoriza pătrunderea în profunzime, după care se aplică un pansament steril pentru protecție.In the case of cuts, cracks and scratches, the ointment can be applied directly to the affected area by light massage, to promote deep penetration, after which a sterile protective dressing is applied.
DRĂGHICI FlorinaDRĂGHICI Florina
DRĂGHICI Laurențin lonuțDRĂGHICI Laurenț lonuț
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO202000060A RO135144A1 (en) | 2020-02-10 | 2020-02-10 | Process for preparing a skin-bioregenerating ointment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024144693A1 (en) * | 2022-12-27 | 2024-07-04 | Istanbul Medipol Universitesi | Unique nanoemulgel formulations developed from combinations of mentha spicata, matricaria chamomilla and cocos nucifera oils and in vitro wound healing effects of the formulations |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024144693A1 (en) * | 2022-12-27 | 2024-07-04 | Istanbul Medipol Universitesi | Unique nanoemulgel formulations developed from combinations of mentha spicata, matricaria chamomilla and cocos nucifera oils and in vitro wound healing effects of the formulations |
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