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Application filed by Universitatea "Alexandru Ioan Cuza" Din IaşifiledCriticalUniversitatea "Alexandru Ioan Cuza" Din Iaşi
Priority to ROA201900163ApriorityCriticalpatent/RO134192A3/en
Publication of RO134192A0publicationCriticalpatent/RO134192A0/en
Publication of RO134192A3publicationCriticalpatent/RO134192A3/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
The invention relates to a process for obtaining a class of anthracene-imidazole compounds with anti-tuberculosis effect. According to the invention, the process consists in the N-alkylation of the nitrogen N1 from the imidazole, and benzimidazole, respectively, with 9-chloromethyl-anthracene, to result in the intermediates 1-(anthracenyl-9-methylene)-1H-imidazole and 1-(anthracenyl-9-methylene)-1H-benzimidazole, followed by the reaction of quaternization with Z-substituted Ω-bromo-acetophenones of the imidazole/benzimidazole nitrogen N3, to result in the 1-(anthracenyl-9-methylene)-3-(2-(4-Z-phenyl)-2-oxoethyl)-1H-imidazol-3-ium bromide and the 1-(anthracenyl-9-methylene)-3-(2-(4-Z-phenyl)-2-oxoethyl)-1H-benzimidazol-3-ium bromide, respectively.
ROA201900163A2019-03-132019-03-13Process for obtaining a new class of anthracene-imidazole compounds with anti-tuberculosis effect
RO134192A3
(en)
1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
4 - ((6- (2- (2,4-DIFLUOROFENIL) -1,1-DIFLUORO-2-HIDROXI-3- (1H-1,2,4-TRIAZOL-1-IL) PROPIL) PIRIDIN-3- IL) OXI) BENZONITRILE AND PROCESS FOR PREPARATION