RO127805B1 - Tothpaste composition - Google Patents

Abstract

The invention relates to a toothpaste composition. According to the invention, the composition has a content of 5...11% biocompatible and biodegradable anionic surfactants comprising 4...6 % mixture of sodium stereate and palmitate, 0.3...0.8% mixture of sodium salts of C12...C20 fatty acids, other than stearic and palmitic acids, up to 0.6% potassium stereate and palmitate mixture, up to 0.4% mixture of potassium salts of C12...C20 fatty acids others than stearic and palmitic acids, 0.3...2% soluble and emulsified fraction, resulting by the saponification of colophony with aqueous sodium hydroxide solution having a content of 20...35% sodium salt of abietic acid and 5...11% natural waxes with adhesive properties, 0.5...3% sodium lauryl diethyl ether sulphate, 0.7...3.5% gelling agent of modified carboxymethylcellulose-type, 7...10% micro- and nanometric mixture of precipitated calcium silicate as grinding and nano sealing agent, 7...10% black locust honey as sweetening agent, 0.2...2% betuline as natural antiinflammatory and bacteriostatic agent and water for the remainder up to 100%.

Description

Invention, within 6 months from the publication of the mention of the decision granted

RO 127805 Β1

The invention relates to a composition for toothpaste with a low content of anionic surfactants.

It is known that toothpastes usually contain a large variety of components with defined functions:

1. Surfactants, usually anionic, in the class of alkaline soaps, alkyl polyether sodium sulphate sulfates or alkyl sulfonates with hydrocarbon chain having linear structure.

2. Microcrystalline or amorphous abrasive and sanding agents, such as calcium or aluminum insoluble salts (carbonates, sulphates, pyrophosphates, orthophosphates, phosphates, silicates), silicon, aluminum, titanium or calcium oxides or peroxides.

3. Organic gelling / binding agents such as carboxymethylcellulose, carrageenan, xanthan, polyvinyl alcohol, polyethylene glycol, hydroxyethyl or hydroxypropyl cellulose, polyols, vinyl polymers of polyethylene, polypropylene, vinyl polychloride, polyamide and nylon, polyamide and polyamide or water-soluble inorganics such as alkali chlorides, citrate, succinate, sodium tartrate, insoluble inorganics such as, for example, colloidal silica, magnesium aluminosilicates, gelled aluminum hydroxide, bentonite or mixtures of organic / inorganic type, such as caragenine and synthetic or amorphous silicon dioxide.

4. Polyol-like humectants, such as glycerin, sorbitol, xylitol, lactitol, polyethylene glycol.

5. Preservatives, usually synthetic products of the type: aliphatic hydroxyl compounds (alcohols), aromatics (polyhalogenated phenols), sodium benzoate, sodium salicylate or formaldehyde.

6. Non-fermentable sweetening agents, natural or synthetic, of the polyol class: glycerin, sorbitol, carbohydrates or saccharin.

7. Fluorine-containing combinations, as fillers: sodium and potassium fluoride, zinc fluoride, fluorophosphates, aminofluorides; or without sodium trimethylphosphate-type fluoride content, and roxyphosphates.

8. Antimicrobial substances: chlorhexidine, metronidazole, quaternary ammonium salts, bis-guanidine, halogenated compounds with bis-phenolic structure.

9. Anti-inflammatory agents; ibuprofen, aspirin, indomethacin.

10. Vitamins of type A, C, E.

11. Dyes.

12. Enzymes of the protease type.

The percentage distribution of the main ingredients used for toothpaste formulation shows the following: 0.2 ... 20% surfactants from natural or synthetic precursors, 5 ... 50% polishing agents, 0.1 ... 8% bleaching agent gelling or mixing of some organic or inorganic gelling / binding agents, 2 ... 70% humectant, 5 ... 70% water. All other types of ingredients with specific functions of preservatives, sweetening agents, flavorings, anti-inflammatory substances, antimicrobials and anti-inflammatories, vitamins, enzymes, respectively, dyes, total 1 ... 25%. GB 1506045 describes an abrasive composition, comprising a hard, micron-sized mineral substance (calcium silicate, etc.), coated with a water-soluble polymeric material; the composition may also comprise water (according to example III, water may be 82.9% by weight), soaps, synthetic detergents (for example, salts with alkali metals of O ₁₂ -C ₁₈ fatty acids), soluble salts sulfonated fatty alcohols in water of the C _1S -C _1O., sweeteners (for example honey, etc.), binders (e.g., sodium carboxymethylcellulose), preservatives.

RO 127805 Β1

EP 0543442 B1 describes a toothpaste with high water content (72.3 ... 80.9% by 1 weight), economical, stable over long periods, possessing the necessary rheological properties and which may comprise anionic surfactants, nonionics, amphoters, such as soaps, 3 alkyl sulphates, alkylbenzene sulphonates, etc. , polishing agents, such as a silicon abrasive agent, a silicon thickening agent, flavors, sweeteners, suspending agents (eg, 5-carboxymethylcellulose sodium), foaming agents (alkyl sulphates), preservatives, fluorine source, antimicrobial agents, anti-cancer agents, anti-lime agents. 7

US 6342205 B1 describes a toothpaste with a high content of water (50 ... 85% by weight), economical, with good stability, comprising in addition to a high content of 9 water, an abrasive material, a binder (of for example, sodium carboxymethylcellulose) and a polyol humectant; it may also contain a source of fluorine, anti-bacterial agents, antibacterial agents. 11

GB 427324 describes cosmetic germicidal compositions and detergents comprising soap (by this term, meaning, according to the invention, salts with alkali metals of 13 fatty acids, salts with alkali metals of abietic acid, salts with alkali metals of synthetic fatty acids by oxidation of petroleum hydrocarbons). 15

RU 2003122327 To describe a curative-prophylactic preparation for the oral cavity care, which includes support materials, additives, an active substance of vegetable origin - 17 betulin and which can be used to obtain toothpastes in various forms: transparent gel, non gel -transparent, emulsion. 19

WO 2009158564 A1 describes a composition for oral hygiene of the mouth, which can be used for obtaining and a toothpaste, in which it can be used as a 21 polishing agent, the rosin and which may also contain bleaching agents, sweeteners, flavors, preservatives , nonionic surfactants, for example, sodium lauryl sulphate, abrasive, for example, 23 silica, a humectant, a polymer, for example, carboxymethylcellulose, a fluorine-containing compound.

Disadvantages of known toothpaste compositions consist of: 25

1. The limited possibilities of increasing the water content, quoted in the reference iteration, to a maximum of 53%, due to the problems related to the segregation of the solid / liquid or organic phase / aqueous phase.

2. High manufacturing costs, determined by the prices of 29 gelling agents of the type carrageenan or other products with similar function, which requires their partial replacement with cheaper products, such as amorphous silicon dioxide, carboxymethylcellulose or 31 xanthan, the latter being unable to allow the significant increase in the water content of the toothpaste composition. Any other formulations that increase the water content 33 to the value of 70%, presented as ideal in the reference literature, involve increasing the concentration of the gelling agent, using a mixture of 35 gelling agents with complementary or synergetic effects, as well as increasing the concentration of the humectant. All of these are unfavorable in terms of reducing the cost of manufacturing 37.

The problem solved by the new composition for toothpaste is that of 39 making a composition of active substances and additives, so as to increase the percentage water content up to the ideal value of 70%, without phase segregation, use of 41 components of plant origin or having as precursors biocompatible and biodegradable plant raw materials, respectively, a polishing agent with micro and 43 nanometric structure that also performs the sealing function,

The object of the invention is a composition for toothpaste, comprising 5 ... 11% 45 biocompatible and biodegradable anionic surfactants, of which 4 ... 6% mixture of stearate and sodium palmitate, 0.3 ... 0, 8% mixture of sodium salts of fatty acids 47 C ₁₂ -C ₂₀ , other than stearic and palmitic acids, 0 ... 6% mixture of stearate and potassium palmitate,

RO 127805 Β1

0.3 ... 2% water-soluble and emulsified fraction, resulting from saponification with sodium hydroxide solution of the rosin, containing 20 ... 35% sodium salt of abietic acid, 5 ... 11% waxes with adhesive properties, 0.5 ... 3% sodium lauryl diethyl ether sulphate, 0.7 ... 3.5% carboxymethylcellulose, as a gelling agent, 7 ... 10% micrometric and nanometric calcium silicate, as a polishing agent and nanosealing, 7 ... 10% acacia honey, as a sweetening agent, 0.2 ... 2% betulin, as a bacteriostatic and anti-inflammatory agent, and water up to 100%.

The invention has the following advantages:

- the composition of toothpaste, characterized by the low content of surfactants and additives, which reduces the manufacturing costs and the impact on the mucous membranes of the oral cavity;

- toothpaste composition, characterized by the fact that all the component organic substances (surfactants, humectants, gelling agents and anti-inflammatories) are biocompatible with the human body and biodegradable;

- the composition of the toothpaste, characterized in that the polishing agent, ie precipitated calcium silicate, a mixture of micro and nanometric particles, also performs the function of nanosigilation of the micro-fissures in the tooth enamel;

- the composition of the toothpaste, characterized in that its gelling and stabilizing system is composed of a certain type of carboxymethylcellulose-walocell, natural waxes of rosin with adhesive and gelling properties, respectively, the sodium salt of the abietic acid, it the latter having both the function of surfactant, as well as of substance with heterocyclic structure, which gives it adhesive properties that favor the stability of the gel, helps to avoid the segregation of the phases, with a favorable impact on increasing the water content up to the ideal value of 70% ;

- the composition of toothpaste, characterized in that the bacteriostatic and anti-inflammatory agents are biologically active plant products: betulin PPS-powder extract and betulin NC-nanocapsules respectively.

Reference literature

RO 112988 B1 / 1993

RO 115408 B1 / 2000

RO 121372 B1 / 2007

Patent Application Publication US 2010/0239618 A1

US Patent Application Publication 2009/0136584 A1

Patent Application Publication US 2008/0187497 A1

US 4140757/1979

US 5356615/1994

US 6324205/2002

GB 427324/1933

GB 506045/1975

UK 122327/2003

EP 0543442 B1 / 1995

WO 158564 A1 / 2009

The following are two examples of embodiments of the invention.

Example 1. A gel consisting of distilled water and carboxymethylcellulose-walocell is prepared, 4% relative to the total mass of the mixture. The complete gelling with the formation of a homogeneous phase takes place in 24 hours, after which it is lightly mixed, using a device with two rotors having the opposite direction of rotation, made of stainless steel with ellipsoidal cutting profiles. An emulsion is prepared

RO 127805 Β1 aqueous formed of the surfactants: sodium stearate, sodium palmitate, 1 sodium salts of other fatty acids (C ₁₂ , C ₁₄ , C ₂₀ ), lauryl diethyl ether sulphate, sodium salt of abietic acid, waxes rosin, betulin-PPS and acacia honey in gravimetric ratio 3 of: 1: 0.89: 0.19: 0.74: 0.11: 0.05: 0.2: 2.22. A determined amount of precipitated calcium silicate with micro- and nanometric particle sizes is suspended in the carboxymethylcellulose-walocell-based gel so that the mass ratio between sodium silicate and carboxymethylcellulose-walocell is 5.2 1, then the silicate is dispersed. of sodium in mass 7 gelled by means of the device of the type described above, at a speed of about 1000 rpm.

After the gel is de-aerated, the aqueous solution of surfactants and 9 additives are continuously added to the gelled solution with suspended calcium silicate content, having the homogenization device in operation, at a speed of 200 .... 300 rpm, until it is obtained of a homogeneous paste 11. The ratio between the two solutions: calcium silicate gel in suspension / aqueous solution of surfactants and additives is 0.92: 1. The composition of the toothpaste thus obtained is: 3.1% sodium stearate, 2.9% sodium palmitate, 3.0% lauryl sodium iethylethersulphate, 0.63% sodium salts of other fatty acids (C ₁₂ , C ₁₄ , C ₂₀ ), 0.34% sodium salt of 15 abetic acid, 0.16% rosin waxes, 1.54% carboxymethylcellulose-walocell, 7.7% acacia honey, 7.8% precipitated calcium silicate micro and nanometric, 0.64% betulin PPS, 17 respectively, 72.17% water, without taking into account the water intake of acacia honey, considered as a unitary system. The product has a good stability of the paste, without the segregation of the phases and 19 an adequate consistency for the discharge from the standardized toothpaste tubes, without collateral losses in relation to the toothbrush. 21

Example 2. A toothpaste is prepared according to the conditions described in the embodiment of the invention, with the exception that, in the emulsified mixture of the surfactants, a mixture of stearate and potassium palmitate is introduced, as well as potassium salts of fatty acids. (C ₁₂ , C ₁₄ and C _2Q ), other than palmitic and stearic acid, in a proportion of 10% compared to 25 similar sodium salts, and instead of betulin PPS - powder extract, betulin NC-nanocapsules are introduced in similar proportions. A composition is obtained for toothpaste, consisting of 27: 2.9% sodium stearate, 2.6% sodium palmitate, 0.55% sodium salts of other fatty acids (C ₁₂ , C ₁₄ , C ₂₀ ) , 0.29% potassium stearate, 0.26% potassium palmitate, 0.06% 29 potassium salts of other fatty acids (C ₁₂ , C ₁₄ and C ₂₀ ), 2.8% sodium lauryl diethyl ether sulfate, 0, 33% abietic acid sodium salt ^ 0.15% rosin waxes, 1.52% carboxymethylcellulose-walocell, 31 7.8% acacia honey, 8% micro- and nanometric precipitated calcium silicate, 0.61% betulin NC - nanocapsules, respectively, 72.73% water, without taking into account the water supply of 33 acacia honey, considered as a unitary system. The product has a good stability of the paste, without the segregation of the phases and a consistency comparable to that of example 1 of embodiment of the invention.

Claims (4)

claims 1. Composition for toothpaste, comprising 5 ... 11% biocompatible and biodegradable anionic surfactants, of which 4 ... 6% mixture of sodium palmitate stearates and 0.3 ... 0.8% mixture of salts sodium of C ₁₂ -C ₂₀ fatty acids, other than stearic and paimitic acids, 0 ... 6% mixture of stearate and potassium palmitate, 0.3 ... 2% water-soluble and emulsified fraction, resulting from saponification with a solution of colofpnium sodium hydroxide, containing 20 ... 35% sodium salt of abietic acid, 5 ... 11% natural waxes with adhesive properties, 0.5 ... 3% sodium lauryl diethyl ether sulphate, 0.7 ... 3.5% carboxymethylcellulose, decay agent, 7 ... 10% calcium silicate micrometric and nanometric, as a polishing and nanosilvering agent, 7., 10% acacia honey, as a sweetening agent, 0.2. .2% betulin, as a bacteriostatic and anti-inflammatory agent, and water up to 100%. 2. A toothpaste composition according to claim 1, characterized in that the polishing and nanosealing agent of the cracks in the tooth enamel is calcium silicate, micrometric and nanometric precipitated mixture, 3. A toothpaste composition according to claim 1, characterized in that the bacteriostatic and anti-inflammatory agent is betulin phosphonate, a soluble powder extract. 4. A toothpaste composition according to claim 1, characterized in that the bacteriostatic and anti-inflammatory agent is betulin in the form of nanocapsules.