RO121372B1 - Toothpaste composition - Google Patents

Abstract

The invention relates to a toothpaste composition based on water, polishing agent, moistener, binder and surfactant comprising 0,5-0,85% carrageenan, at least 70% of the carrageenan being iota carrageenan.

Description

The invention relates to a stable, high water content toothpaste composition comprising a carrageenan as a binder, a calcium polishing agent, a humectant, a surfactant, water and optionally additives and therapeutically active agents used in toothpaste compositions. In particular, the invention relates to a stable, high water content toothpaste, wherein the weight percentage of the polishing agent is in the range of 35 to 50%, of the water is between 35 and 50%, of the humectant it is between 5 and 15%, of the carrageenan it is between 0,5 and 0,85% and at least 70% of the caragenin content is l-caragenine.

Toothpastes usually contain the following types of ingredients: a polishing or abrasive agent, a humectant, a binder or a thickening agent, a surfactant and water. Humidifier and water are collectively referred to as carriers. In addition, agents that provide therapeutic or cosmetic benefits, such as preservatives, fluorides, flavoring agents, sweeteners and tartar control agents, may be incorporated. Toothpaste formulations can have wide variations in the specific types of ingredients and the quantities of ingredients used. Commonly, toothpastes contain 0.1 to 8% of a binder which is often referred to as a thickening agent or gelling agent, 5 to 70% water, 2 to 70% wetting agent, 5 to 50% agent polish, 0.2 to 20% surfactant and 0.1 to 25% other ingredients or adjuvants such as flavoring agents, sweeteners, fluorides, anti-tartar agents, preservatives, anti-deposition agents and other therapeutically active ingredients compatible with toothpastes, the percentages being expressed by weight.

To the satisfaction of consumers, toothpaste formulations must have certain excellent physical properties with which the consumer is accustomed. These properties give the toothpaste an attractive taste, a good cleansing effect, a light rinse, flavor and physical stability. Toothpastes with acceptable physical stability do not heal quickly on the shelf and do not exhibit the phenomenon of phase separation such as water or flavor separation. The appearance of the toothpaste when leaving the dispenser is also considered important. The paste should be smooth and look shiny and glossy.

Caragenine is known as an effective binder that provides toothpaste formulations with the desired properties mentioned above. Caragenins form thixotropic gels. Such gels are known to have excellent extrudability, flavor release and rinsing ability. It is also known that using K-carrageenan and l-carrageenan as gel toothpaste binders results in a non-sticky toothpaste.

The generic term carrageenan is used for dozens of similar polysaccharides from marine algae. All caragenins contain repeated galactose units, linked by alternative glycosidic linkages β1 -3 and 1-4 and are partially sulfated. The types of carrageenan can be partially distinguished by their degree of sulfation.

K-carrageenin (kappa-carrageenan) has a repeated unit of D-galactose-4-sulfate-3,6 anhydrous-D-galactose which provides a sulfate ester content of about 18 to 25%. I-caragenine (iota-caragenine) has a repeat unit of D-galactose-4-sulfate-3,6-anhydrous-D-galactose-2-sulfate which provides a sulfate ester content of about 25 to 34%. A-caragenine (lambda-caragenine) has a repeat unit of D-galactose-2-sulfate-D- galactose-2,6-disulfate which provides a sulfate ester content of about 30 to 40%.

Ideally, the physical properties mentioned above are provided with a cost-effective toothpaste for the consumer. There is a continuous demand for low-cost toothpaste, but with maintaining the desired properties. This is especially important in those parts of the world where, despite the well-established advantages in dental hygiene, toothpaste is still inaccessible. A proposal for a low-cost toothpaste is to look for cheap substitutes for specific, high-cost ingredients.

RO 121372 Β1

Caragenine is, for example, a relatively expensive ingredient. Caragenine can sometimes be used in smaller quantities when mixed with gums and other thickening agents such as carboxymethylcellulose and xanthan. US Patent 4,407,757 discloses the replacement of part 3 of the caragenine binder from a toothpaste formulation with a cheap, synthetic thickening agent, amorphous silicon dioxide. When part of the carrageenan is replaced with other binders, the total concentration of the binder should often be higher than if only the carrageenan is used as the binder. 7

Another proposal to reduce the cost of toothpaste is to obtain a toothpaste with high water content. Generally, high water content toothpastes (or high humidity toothpastes) are expected to be cheaper due to the low cost of water compared to other ingredients. The content of water 11 in toothpaste has been reported to vary between 5 and 70% by weight, but most toothpastes have a water content of about 10 to 25% by weight. 13

Obtaining a high humidity toothpaste that has the desired physical properties is a challenge. Relatively high water content is often associated with problems of low viscosity and / or phase separation. During storage, water tends to move downward, and oils, such as flavorings, move upward. At 17 toothpastes with high humidity, the consumer can notice the "wet lid" or the concentration of the aroma at the top, depending on how the tubes were stored. Separation 19 may also affect the brightness or gloss of the extruded paste.

Highly moistened toothpastes and carrageenan are known. The following 21 patents describe various toothpaste formulations comprising carrageenan as a binder and having a water content greater than about 30% by weight: US 4340583,4814160.4826675, 23

5096609, 5208009 and 5356615. High humidity toothpastes containing carrageenan are generally formulated with humectants of more than 20% by weight and / or with the use of several thickening agents.

It is an object of the present invention to obtain a high humidity toothpaste, 27 with favorable physical properties, comprising a toothpaste formulation in which the carrageenan is present in a concentration of not more than about 0.85%, and the concentration Total 29 humectant is not more than about 15%. Another object of the invention is to provide such a formulation which has favorable physical properties, without the need for additional binder 31.

A stable, high humidity toothpaste was obtained comprising carrageenan33 as a binder, a calcium polishing agent, a humectant, a surfactant, water and optional additives and therapeutically active ingredients used in toothpaste compositions. The calcium polishing agent is present at a concentration of about 35 to 50% by weight, water is about 35 to 50%, the humectant is about 537 to 15%, the surfactant is about 0.5 to at 5%, the carrageenan is about 0.5 to 0.85% and at least 70% of the caragenin content is l-caragenine. The high-moisture-to-obtain toothpaste has favorable physical properties such as good viscosity and stability without the need for additional binder which can be optionally added.

The present invention provides stable, low-moisture, 43 low-cost toothpaste compositions, which have an excellent balance of properties, comprising approximately 0.5 to 0.85% by weight of carrageenan, at least 70% by weight. l-carrageenan, water 45 about 35 to 50% by weight, calcium or abrasive polishing agent about 35 to 50% by weight, wetting about 5 to 15% by weight, 47 and about surfactant 0.5 to 5% by weight.

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Optional ingredients that may be present include silica up to about 5%, by weight, and small amounts of 0.5 to 3.0%, by weight, additional adjuvants such as flavors, preservatives, sweeteners, fluorides, anti-tattoos , anti-deposits and other therapeutically active ingredients compatible with the toothpaste that are the subject of the present invention. The percentages of the ingredients used in this description are expressed by weight and refer to the pure ingredient in the toothpaste, unless otherwise stated.

In one of the formulations of the invention, the weight percentage of carrageenan is in the range of about 0.55 to 0.65%. In this formulation, a preferred weight percentage of water is in the range of about 36 to 50%, more preferably 36 to 46%, a preferred weight percentage for the humectant is about 7 to 14% and a percentage in Preferred weight for the polishing agent is about 40 to 46%, more preferably about 43 to 46%.

In another formulation, the percentage by weight of carrageenan is in the range of about 0.7 to 0.8%. In this embodiment, a preferred weight percent for water is in the range of about 40 to 50 percent, a preferred weight percent for the humectant is about 7 to 14 percent, and a preferred weight percent for the polishing agent is about 40 to 46, more preferably about 40 to 43%.

Many of the disadvantages of high humidity toothpastes are outweighed by the compositions presented in this invention. They have good Cuban values (good consistency) and good stability in terms of water or flavor separation and long-term hardening. In addition, when stored on the shelf, toothpastes are fine and have a pleasant shiny and glossy appearance. These favorable properties have been obtained for a relatively low cost formulation, due in large part to the low levels of humectants that are needed.

High humidity toothpastes according to the present invention require l-carrageenan as the main component of the carrageenan type. l-carrageenan is at least 70% by weight of carrageenan, preferably at least 90%. In this invention, small amounts (less than 30% by weight) of other caragenins, preferably K-carrageenan, may be used together with l-caragenine. Caragenine usually contains a mixture of cations associated with sulphate groups of caragenine, so that the carrageenan is provided as a partial salt. Associated cations are cations of alkali metals and alkaline earth metals, such as sodium, potassium and calcium. It is preferable that about 9 to 12% of the l-carrageenan is in the form of a salt, preferably as a sodium or potassium salt with a minimum amount, less than 1% of the calcium salt of the l-carrageenan. It is also preferred that the viscosity of the carrageenan be medium or high. Viscosity refers to the viscosity of a solution of 1.5% carrageenan in water at 75 "C. The term high viscosity means a water viscosity of at least 50 cps, average viscosity means a water viscosity of about 40 to 50 cps, and low viscosity means a viscosity of less than 40 cps. A preferred carrageenan for use in the toothpastes of the present invention is available from FMC Corporation under the name of Viscarin® 399. Another preferred carrageenan is available from the EMC under the name of Viscarin® 329. The weight percent of the carrageenan is within the range from about 0.5 to 0.85%. A preferred weight percentage of carrageenan is in the range of about 0.55 to 0.80%. Caragenine may be used in combination with small amounts (0 to 0.50%, by weight) of other binders, such as other caragenins, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethylcarboxyethyl cellulose, polyvinyl pyrrolidone, gumaragagyl, hydroxypropagyl, hydroxy ethyl cellulose, starch, glycolated starch, polyvinyl alcohol, sodium alginate, Ceratonia Siliqua gum and hydrophilic hydrophilic colloidal polymers, such as Carbopol® to obtain high humidity toothpaste.

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The common carriers for toothpaste are water and one or more humectants. 1 The water used can be any treated water, such as tap water, well water or spring water. Often, before use the water is deionized. Suitable humectants are 3 acyclic or cyclic polyols known to have 3 to 6 carbon atoms and mixtures thereof. Preferred humectants are glycerol and sorbite. Sorbitol was used as a 70% solution in 5 water, which is a form of sorbitol available immediately. The percentages of humectants such as sorbitol refer to the pure humectant in toothpaste, unless otherwise specified. A preferred 7 percent by weight for sorbitol is in the range of about 7 to 14%. The use of glycerol-sorbitol mixtures is well known. When such a mixture is used, a preferred amount of glycerol is about 0 to 7% by weight. Other liquid polyols, such as polyethylene glycols, 11 mannitol, xylitols, other sugar alcohols and polyoxyethylene alcohols, may also be used. An advantage of this invention is that large amounts of humectants are not required in the high water content formulation 13 to compensate for the low binder concentration.

The calcium-polishing agents used in the composition according to the invention include 15 calcium-based agents known to be useful in toothpastes. These are powdery materials that are not water soluble or have very low water solubility and a preferred particle size of about 1 to 40 μm, more preferably about 2 to 20 μm, with distributions normal particle size. All these 19 agents have polishing activity without being abrasive. Suitable calcium-based polishing agents include dicalcium phosphate, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, 21 calcium silicate and calcium aluminate. These polishing agents can be used in conjunction with other abrasives such as crystalline silica, colloidal silica, aluminosilicate complexes, 23 aluminum hydroxide (including aluminum trihydrate), magnesium phosphate, magnesium carbonate, bentonite, talc, aluminum oxide, aluminum silicate and silicon xerogels. A preferred calcium-based polishing agent is precipitated calcium carbonate.

The surfactants (detergents) that can be used in the toothpaste according to the invention, 27 are those commonly used for emulsification or for uniform dispersion of toothpaste components. It is generally preferred that the detergent be anionic or non-ionic or a mixture thereof. Suitable types of anionic detergents include sodium lauryl sulfate, fatty acid monoglyceride sulphates, fatty alkyl sulphates, higher alkyl sulfonated aryls, 31 upper alkyl sulfoacetates, higher olefinic sulphonates, upper aliphatic acylamides of lower alkyl aminic acids (with 3 to 33 per 100 alkoxy groups) and soaps of fatty acids. Examples of anionic detergents include sodium lauryl sulfate, sodium monosulfate of hydrogenated fatty acids monoglyceride from coconut oil, sodium N-lauroyl sarcozide and sodium coconut. Suitable types of non-ionic detergents include lower alkylene oxide chains such as ethylene oxide and 37-propylene oxide.

Additional materials that are optionally added include flavorings, enamel hardening agents and antibacterial compounds. Flavoring materials include saccharin sweetener, essential oils such as grass, peppermint, blackberry, eucalyptus, lemon and lime 41. Curing agents include sodium monofluorophosphate, sodium fluoride and tin fluoride. Antibacterials are sodium benzoate and methyl or ethyl parasite. 43

High humidity toothpastes according to the present invention can be prepared by a continuous or continuous process. A continuous process that can be used to obtain the toothpaste according to the present invention is described in US Patent 5,236,696 (Catiis et al.). 47

The following are 53 examples of embodiments of the invention.

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Toothpaste formulations were prepared by both a hot process and a process at ambient temperature. The hot process has the following steps:

(1) Dispersing the binder in the humectant by stirring for 10 minutes with a high speed shaker to form a gel;

(2) heating the water at 80'C and adding to the humectant with further stirring for 15 minutes, maintaining the temperature between 65 and 70'C;

(3) Dry mixing of sodium saccharin and sodium benzoate. The dry mixture is then mixed in the binder suspension and stirred for 15 minutes, maintaining the temperature between 65 and 70'C;

(4) Transferring the gel (elixir) obtained in a Ross low speed mixer with a vacuum attachment. The Ross ™ mixer is a well-known device, with two planetary wheels, and with two mixing blades that operate at 20 to 100 rpm and can operate under vacuum;

(5) Add in the elixir of precipitated calcium carbonate and, optionally, a small amount of silica, stirring for 15 minutes under vacuum (at least 720 mm Hg).

(6) Add the flavorings to the elixir and mix for 10 minutes in the Ross mixer under total vacuum.

(7) Add the surfactant and sodium lauryl sulfate to the mixture and continue stirring under vacuum for 20 minutes.

(8) Extracting a sample for testing and removing the filler.

The process that is carried out at ambient temperature has the same steps as the process that is carried out in the heat, except for the steps (2) and (3) in which the temperature used is the temperature of the environment. Numerous tests were performed on the experimental batches for both the hot process and the ambient temperature process.

In the tables below, Cgn A-D are l-carrageenan, each associated with cations, sodium and potassium being predominant. Cgn A is a medium-viscosity carrageenan, Cgn B is a high-viscosity carrageenan, Cgn C has a viscosity of between 5 to 50 cps, for a 1.5% solution, at 75 ° C and Cgn D is a carrageenan with low viscosity containing about 10% silica zeodent. Cgn E is K-carrageenan extract, SCTIP 105 is l-carrageenan marketed by Shemburg and KPFX 8806 is high viscosity l-carrageenan marketed by Copenhagen Pectin. CMC 7MF, CMC (9M31F) Aqualon and Daicel are commercially available carboxymethylcellulose.

Comparisons were made between a number of formulations with varying amounts of different caragenins, water, humectant and polishing agent. To evaluate the effect of ingredients and quantities on Cuban values and stability, the other components of the formulations were kept constant. Table 1 lists the ingredients whose quantities have been kept constant in a set of comparisons.

Table 1

Other ingredients besides Cgn, water, polishing agent and humectant

Ingredient Percent,% Sodium sugar 0.20 Sodium benzoate 0.30 Flavor 1.00 Sodium lauryl sulfate 2.00

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Table 2 illustrates some of the formulations containing the ingredients in Table 1 and varying amounts of carrageenan A, water, humectant and polishing agent. The formulations in Table 2 were prepared by the hot process described above. The term sorbitol 70 refers to a solution of 70% sorbitol in water.

Table 2 Representative toothpaste with carrageenan A, obtained by the hot process

Nr. Cgn A Sorbitol 70 Glycerin CaCO ₃ precipitated The water 1 0.80 15.0 - 42.0 38.70 2 0.80 15.0 - 40.0 40,70 3 0.80 15.0 40.0 40,70 4 0.75 15.0 40.0 40.75 5 0.80 10.0 40.0 45.70 6 0.80 15.0 43.0 37.70 7 0.75 15.0 43.0 37.75 8 0.65 15.0 46.0 34.85 9 0.55 20.0 46.0 29.95 10 0.65 20.0 40.0 35.85 11 0.65 20.0 46.0 29.85 12 0.80 20.0 40.0 35.70 13 0.80 20.0 46.0 29.70 14 0.58 15.0 46.0 34.92 15 0.65 10.0 43.0 42.85 16 0.65 15.0 43.0 37.85 17 0.65 10.0 43.0 42.85 18 0.60 15.0 43.0 37.90

Table 3 illustrates certain formulations containing the ingredients in Table 1 and 27 varying amounts of caragenin B, water, sorbitol and polishing agent. The formulations in Table 3 were prepared by the hot process described above. 29

Table 3 31

Representative toothpaste with Cgn B, obtained by the hot process

Nr. Cgn B Sorbitol 70 CaCO ₃ precipitated Precipitated silica The water 19 0.65 15.00 46.00 - 34.85 20 0.80 10.00 40.00 - 45.70 21 0.60 15.00 46.00 - 34.90 22 0.60 15.00 46.00 - 34.90

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Table 3 (continued)

Nr. Cgn B Sorbitol 70 CaCO ₃ precipitated Precipitated silica The water 2. 3 0.60 15.00 45.00 - 35,90 24 0.60 15.00 44,00 - 36.90 25 0.55 15.00 46.00 - 34.95 26 0.55 15.00 45.00 - 35.95 27 0.55 15.00 44,00 - 36.95 28 0.70 15.00 40.00 - 40.80 29 0.55 15.00 43,00 2.00 35.95 30 0.55 20.00 43,00 2.00 30.95

Table 4 illustrates some formulations containing the ingredients in Table 1 and variable amounts of carrageenan B, water, sorbitol and polishing agent. The formulations in Table 4 were prepared by the process at ambient temperature described above.

Table 4

Pastes of being representative with Cgn B and obtained by the process at ambient temperature

Nr. Cgn B Sorbitol 70 CaCO ₃ precipitated Precipitated silica The water 31 0.60 15.00 46.00 - 34.90 32 0.60 15.00 46.00 - 34.90 33 0.60 15.00 46.00 - 34.90 34 0.60 15.00 45.00 - 35,90 35 0.60 15.00 44,00 - 36.90 36 0.55 15.00 46.00 - 34.95 37 0.55 15.00 45.00 - 35.95 38 0.55 15.00 44,00 - 36.95 39 0.55 15.00 43,00 2.00 35.95 40 0.55 20.00 43,00 2.00 30.95 41 0.60 15.00 46.00 - 34.90

Table 5 illustrates some formulations containing the ingredients in Table 1, with different caragenins. The formulations in Table 5 were prepared by the hot process described above.

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Table 5 1

Toothpaste with various caragenins

Nr. carrageenan Sorbitol 70 CaCO ₃ precipitated The water type % 42 Cgn C 1.40 15.00 40.00 40.10 43 SCI TP 105 0.80 15.00 40.00 40,70 44 KPF X 8806 0.80 15.00 40.00 40,70 45 Cgn D 0.80 15.00 40.00 40,70 46 Cgn D 0.80 15.00 40.00 40,70 47 Cgn D 0.75 15.00 40.00 40.75 48 Cgn D 0.80 15.00 40.00 45.70 49 Cgn D 0.65 15.00 46.00 34.85 50 ¹ Cgn E 0.50 15.00 43,00 37.70

¹ CMC Daicel (0.30%) added to the formulations

Table 6 illustrates comparatively some low humidity formulations, which contain 15 ingredients in Table 1 and carrageenan A. The formulations in Table 6 were made with less water and more humectant, and were prepared by the hot process described above. 17

Table 6 19

Low humidity toothpaste, comparatively

Nr. Cgn A Sorbitol 70 Glycerin CaCO ₃ precipitated The water 51 0.62 - 25.00 46.00 24.88 52 0.62 25.00 - 46.00 24.88 53 0.65 25.00 - 46.00 24.85

Test results

For each of the prepared formulations, Cuban values and 27 physical stability were measured.

The values of the Cuban test are directly related to the viscosity of the toothpaste. In Test 29 Cuban, (also called the Grill test) the paste is squeezed from a tube through a fixed orifice over a network of parallel rods spaced apart. The results of the test are expressed as 31 the largest number of the space (the numbers are from 1 to 12) which represents the largest distance between the rods that support the toothpaste ribbon without breaking. The grill is 33 approximately 300 mm long and approximately 100 mm wide. Stainless steel rods are spaced with increasing spacing from 3 mm between rods 1 and 2 (space number 1) and the distance between the rods increases by 3 mm from one rod to another. Thus, the distance between rods 2 and 3 is 6 mm and the distance between rods 12 and 13 (space number 12) is 39 mm. Values 1-2 37 and 9-12 are not acceptable, 3 and 8 are acceptable, 4-7 are good.

In carrying out the Cuban test, the following procedure is used: 39 (1) At a tube filled with toothpaste to be tested, fix a tip;

(2) The tube filled with toothpaste and with the tip attached is maintained at an angle of 45'41 from the barbecue device. Apply pressure to the bottom of the tube and squeeze a uniform ribbon of toothpaste from the tube. 43

EN 121372 Β1 while the paste ribbon is extruded from the tube, the tube is moved over the grate in a straight line as quickly as possible. There is no time limit set to stretch the ribbon of pasta over the grill. If the ribbon breaks before crossing the entire grate, the procedure is repeated.

(3) The ribbon is left for 30 s. At this point, the point at which the ribbon breaks is recorded as the Cuban value.

(4) The test is performed five times and the average is recorded, rounding by lack to the nearest whole value.

The stability tests were made by filling the tubes with the sample paste. The tubes were blocked and stored for 12 weeks at room temperature and at a temperature of 50'C. After 12 weeks of exposure, a toothpaste tape about 5 cm long was squeezed out of the tube. The tube was then split and the ribbon and the contents were evaluated to determine the aroma and a possible phase separation (synergy). The separation of the aroma and water phases at the tip of the toothpaste tube can be retained as a wet lid. Flavor separation was noted as 0 = not at all, 1 = easy, 2 = moderate and 3 = severe. Stability was rated as unsatisfactory, satisfactory and good. To be unsatisfactory, the sample must present some undesirable properties such as flavor separation, synergy, hardening in the tube, or unacceptable Cuban values. In order to be satisfactorily scored, the sample does not have to separate but is slightly granular and lacks an intense glow. To be well noted, the sample should not have phase separation and be superior in subtle details such as texture, not be granular and have a higher gloss and gloss.

Table 7 shows the results of the Cuban test and the stability test for the formulations described in tables 1-6

Table 7

Test results

Nr. Cuban value Stability Nr. Cuban value Stability rt 50 ° C rt and 50 ° C 1 9 satisfactory. - 28 6 good good 2 7 satisfactory. satisfactory. 29 4 satisfactory. satisfactory. 3 7 satisfactory. satisfactory. 30 4 satisfactory. satisfactory. 4 7 good satisfactory. 31 6 satisfactory. satisfactory 5 7 satisfactory. satisfactory. 32 4 satisfactory. satisfactory. 6 10 good good 33 6 satisfactory. satisfactory. 7 8 satisfactory. satisfactory. 34 5 good good 8 8 satisfactory. satisfactory. 35. 5 good good 9 5 satisfactory. satisfactory. 36 5 good good 10 6 satisfactory. satisfactory. 37 5 good good 11 6 satisfactory. satisfactory. 38 5 good good 12 6 good good 39 4 satisfactory. satisfactory.

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Table 7 (continued) 1

Nr. Cuban value Stability Nr. Cuban value Stability rt 50 ° C rt and 50 ° C 14 5 unsatisfactory. unsatisfactory 41 6 - good 15 5 satisfactory. satisfactory. 42 6 unsatisfactory. unsatisfactory. 16 5 satisfactory. satisfactory. 43 7 unsatisfactory unsatisfactory 17 4 satisfactory. satisfactory. 44 3 unsatisfactory. unsatisfactory. 18 4 good good 45 5 satisfactory. - 19 9 good good 46 5 unsatisfactory unsatisfactory 20 9 satisfactory. satisfactory. 47 4 unsatisfactory. unsatisfactory. 21 8 satisfactory. satisfactory. 48 5 unsatisfactory. unsatisfactory. 22 8 - unsatisfactory. 49 5 unsatisfactory. unsatisfactory. 2. 3 5 - satisfactory. 50 4 unsatisfactory. unsatisfactory. 24 5 - satisfactory. 51 5 good good 25 6 good good 52 5 good good 26 5 unsatisfactory. - 53 5 satisfactory. satisfactory. 27 5 satisfactory. satisfactory.

In some samples, the separation occurred inside the tube. These formulations that have more than a slight separation (grade 2-3) are listed in Table 8.

Table 8

Toothpastes with moderate to severe flavor separation 23

Flavor separation note Sample numbers 2 22, 46 3 42, 43, 44, 47, 48, 49, 50

As shown in Table 7, a number of formulations of the present invention have acceptable Cuban values and a stability value that is satisfactory or good. These 29 desired physical properties were achieved in high water content toothpaste formulations, with relatively low concentrations of binder and humectant. It is obvious that 31 various modifications of the formulations of the present invention can be made without departing from the inventive concepts herein, as defined in the claims. 33

Claims (10)

Claims 35 1. Water based toothpaste composition, polishing agent, humectant, binder 37 and surfactant, characterized in that it comprises 0.5 to 0.85% caragenine, at least 70% of the caragenine being carrageenan, 35 to 50% water, 35 to 39 to 50% calcium or abrasive polishing agent, 5 to 15% wetting agent and 0.5 to 5% surfactant, all percentages being expressed by weight. 41 RO 121372 Β1 A composition according to claim 1, characterized in that at least 90% of the carrageenan is l-carrageenan. 3. A composition according to claim 1 or 2, characterized in that it comprises 0.55 to 0.80% caragenine, 36 to 50% water, 40 to 46% calcium-based polishing agent and 7 to 14 % wetting, all percentages being expressed by weight. 4. A composition according to claim 1 or 2, characterized in that it comprises 0.55 to 0.65% carrageenan, 36 to 46% water, 43 to 46% calcium polishing agent, all percentages being expressed. by weight. 5. A composition according to claim 1 or 2, characterized in that it comprises 0.70 to 0.80% carrageenan, 40 to 50% water, 40 to 43% calcium-based polishing agent, all percentages being expressed. by weight. Composition according to claims 1 to 5, characterized in that the polishing agent is selected from precipitated chalk and dicalcium phosphate. Composition according to claims 1 to 6, characterized in that the humectant is sorbitol, glycerin or a mixture thereof. 8. A composition according to claims 1 to 7, characterized in that the surfactant is sodium lauryl sulfate. A composition according to claims 1 to 7, characterized in that the polishing agent is precipitated chalk, the surfactant is sodium lauryl sulfate, and the humectant is sorbitol. 10. Composition according to claims 1 to 9, characterized in that it has a Cuban value in the range 3 ... 8.