RO115694B1 - Bioartifcial material for implants - Google Patents
Bioartifcial material for implants Download PDFInfo
- Publication number
- RO115694B1 RO115694B1 RO9700726A RO9700726A RO115694B1 RO 115694 B1 RO115694 B1 RO 115694B1 RO 9700726 A RO9700726 A RO 9700726A RO 9700726 A RO9700726 A RO 9700726A RO 115694 B1 RO115694 B1 RO 115694B1
- Authority
- RO
- Romania
- Prior art keywords
- calcium
- acid
- kda
- average molecular
- acrylate
- Prior art date
Links
- 239000000463 material Substances 0.000 title claims abstract description 8
- 239000007943 implant Substances 0.000 title claims abstract description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 13
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960005069 calcium Drugs 0.000 claims abstract description 10
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 10
- 239000011575 calcium Substances 0.000 claims abstract description 10
- 102000008186 Collagen Human genes 0.000 claims abstract description 6
- 108010035532 Collagen Proteins 0.000 claims abstract description 6
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229920001436 collagen Polymers 0.000 claims abstract description 6
- 239000000178 monomer Substances 0.000 claims abstract description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229920001577 copolymer Polymers 0.000 claims abstract description 5
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims abstract description 4
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims abstract description 4
- 239000001527 calcium lactate Substances 0.000 claims abstract description 4
- 229960002401 calcium lactate Drugs 0.000 claims abstract description 4
- 235000011086 calcium lactate Nutrition 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims abstract description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 4
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims abstract description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims abstract description 3
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000005977 Ethylene Substances 0.000 claims abstract description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims abstract description 3
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000001110 calcium chloride Substances 0.000 claims abstract description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 3
- 229960002713 calcium chloride Drugs 0.000 claims abstract description 3
- 235000011148 calcium chloride Nutrition 0.000 claims abstract description 3
- 239000004227 calcium gluconate Substances 0.000 claims abstract description 3
- 229960004494 calcium gluconate Drugs 0.000 claims abstract description 3
- 235000013927 calcium gluconate Nutrition 0.000 claims abstract description 3
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 3
- 229960001714 calcium phosphate Drugs 0.000 claims abstract description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims abstract description 3
- 239000002131 composite material Substances 0.000 claims abstract description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims abstract description 3
- 239000011976 maleic acid Substances 0.000 claims abstract description 3
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims abstract description 3
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims abstract description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims abstract description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims abstract description 3
- 150000003839 salts Chemical class 0.000 claims abstract description 3
- 239000000126 substance Substances 0.000 claims abstract description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- 150000002735 metacrylic acids Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002348 vinylic group Chemical group 0.000 abstract 1
- 239000007787 solid Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920005996 polystyrene-poly(ethylene-butylene)-polystyrene Polymers 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
Invenția pentru implant se referă la un material bioartificial pentru implant pe bază de colagen și polianioni sintetici intercuplat cu calciu care este destinat tratamentelor afecțiunilor cu deficit de calciu sub formă de implanturi.The invention for the implant relates to a bioartificial material for implant based on collagen and synthetic polyanions interspersed with calcium which is intended for the treatment of calcium deficiency disorders in the form of implants.
Se cunoaște o compoziție de material bioartificial pe bază de colagen, glicozaminoglican, factor de creștere, copolimer stiren anhidridă - maleică.A composition of bioartificial material based on collagen, glycosaminoglycan, growth factor, styrene anhydride-maleic copolymer is known.
Materialul bioarticifial pentru implant, conform invenției, este un compozit polimeric cu configurație tridimensională, constituit din 15...25% colagen solubil, cu masa moleculară medie de 300 kDa, 50...70% copolimer anionic cu formula generală (A-B)n, de compoziție chimică A:B = 50:50...95: 5 și cu masa moleculară medie de 20...100 kDa, în care A este un monomer polimerizabil cu grupări carboxilice libere ales între acid acrilic, acid metacrilic, acid maleic sau acid itaconic, iar B un monomer vinilic ales dintre acrilat de metil, metacrilat de metil, acrilat de butii, acrilat de etil, 2-hidroxi metilmetacrilat, acetat de vinii, stiren, etilenă sau propilenă, 5...10% condroitin sulfat și până la 100% calciu insolubil în apă și atomi de calciu proveniți din săruri solubile alese dintre clorură de calciu, lactat de calciu, fosfat de calciu sau gluconat de calciu, procentele fiind exprimate în greutate.The bio-artificial material for the implant, according to the invention, is a polymeric composite with three-dimensional configuration, consisting of 15 ... 25% soluble collagen, with an average molecular mass of 300 kDa, 50 ... 70% anionic copolymer of general formula (AB) n , of chemical composition A: B = 50:50 ... 95: 5 and with an average molecular weight of 20 ... 100 kDa, wherein A is a polymerizable monomer with free carboxylic groups chosen from acrylic acid, methacrylic acid, acid maleic or itaconic acid, and B a vinyl monomer selected from methyl acrylate, methyl methacrylate, butyl acrylate, ethyl acrylate, 2-hydroxy methylmethacrylate, vinyl acetate, styrene, ethylene or propylene, 5 ... 10% chondroitin sulphate and up to 100% water-insoluble calcium and calcium atoms from soluble salts chosen from calcium chloride, calcium lactate, calcium phosphate or calcium gluconate, the percentages being expressed by weight.
Aplicarea invenției are următoarele avantaje:Application of the invention has the following advantages:
- materialul bioartificial se poate utiliza sub formă de gel sau în stare solidă;- the bioartificial material can be used in gel form or in solid state;
- conține calciu legat chimic și difuzibil în proporții variabile asigurând retardarea, atât prin mecanism difuzional, cât și prin erodare enzimatică;- contains calcium bound and chemically diffusible in variable proportions ensuring retardation, both by diffusion mechanism and by enzymatic erosion;
- gelul se poate profila prin matrițare în vederea obținerii de biomateriale solide cu geometrie complexă, ca înlocuitori de țesuturi conjunctive rigide sau flexibile;- the gel can be profiled by molding in order to obtain solid biomaterials with complex geometry, as substitutes for rigid or flexible connective tissues;
- este biocompatibil, neresorbabil sau resorbabil.în funcție de necesități;- it is biocompatible, non-absorbable or resorbable. depending on needs;
- tehnologia de obținere este simplă și nu necesită temperaturi ridicate.- The technology is simple and does not require high temperatures.
In continuare, se dau două exemple de realizare a invenției.The following are two examples of embodiments of the invention.
Exemplul 1. Intr-un vas de amestecare de 5 I, prevăzut cu agitator se introduc 2 I de soluție apoasă, cu pH = 8, de copolimer de acid acrilic și metacrilat de metil ce conține 60% acid acrilic, cu masa moleculară medie de 100 kDa, de concentrație 2%, 0,8 I de soluție de colagen de concentrație 2% și pH = 0,5 I de soluție de condroitin sulfat A cu pH = 8 și concentrație 0,5% și un litru de soluție de clorură de calciu de concentrație 1%. După 2 h de agitare moderată la temperatura, de 40°C gelul opac format se separă prin decantare și se usucă, la 60°C la vid. Se obțin 62,2 g de material bioartificial solid ce conține 9,6% calciu legat și 4,8% calciu difuzibil.Example 1. In a mixing vessel of 5 L, provided with a stirrer, add 2 L of aqueous solution, with pH = 8, of copolymer of acrylic acid and methyl methacrylate containing 60% acrylic acid, with average molecular weight of 100 kDa, 2% concentration, 0.8 I collagen solution 2% and pH = 0.5 I chondroitin sulfate solution A with pH = 8 and 0.5% concentration and one liter chloride solution calcium concentration 1%. After 2 hours of moderate stirring at 40 ° C, the opaque gel formed is separated by decantation and dried at 60 ° C under vacuum. 62.2 g of solid bioartificial material containing 9.6% bound calcium and 4.8% diffusible calcium are obtained.
Exemplul 2. Același procedeu ca la exemplul 1, cu deosebirea că se folosește copolimer de stiren și acid maleic cu masa moleculară medie de 20 kDa și lactat de calciu. Se obțin 70,3 g de material bioarticial solid ce conține 7,6% calciu legat și 6,1% calciu difuzibil.Example 2. The same procedure as in Example 1, except that styrene and maleic acid copolymer with average molecular weight of 20 kDa and calcium lactate are used. 70.3 g of solid bioarticial material containing 7.6% bound calcium and 6.1% diffusible calcium are obtained.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO9700726A RO115694B1 (en) | 1997-04-15 | 1997-04-15 | Bioartifcial material for implants |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO9700726A RO115694B1 (en) | 1997-04-15 | 1997-04-15 | Bioartifcial material for implants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO115694B1 true RO115694B1 (en) | 2000-05-30 |
Family
ID=20105095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO9700726A RO115694B1 (en) | 1997-04-15 | 1997-04-15 | Bioartifcial material for implants |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO115694B1 (en) |
-
1997
- 1997-04-15 RO RO9700726A patent/RO115694B1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI96218C (en) | Hydrophilic, swellable graft polymers, their preparation and use | |
| DK1030697T3 (en) | Biodegradable polymer skeleton | |
| ES2082139T3 (en) | SHAMPOO COMPOSITIONS. | |
| WO1993024098A1 (en) | Cosmetic film forming compositions | |
| WO1995006454A1 (en) | Cosmetic film forming compositions which are freeze-thaw stable | |
| AR245499A1 (en) | Dual polymer self-sealing detergent compositions and methods | |
| KR920019827A (en) | Low molecular weight monoalkylphosphinates and phosphonate copolymers | |
| CN101934097A (en) | Injectable composite bone cement of hydroxyapatite-PMMA containing strontium, preparation method and application thereof | |
| CA2224237A1 (en) | Acrylate-containing polymer blends | |
| MY125264A (en) | Skin cleansing composition comprising a mixture of thickening polymers | |
| BR9911170A (en) | Alkali soluble latex thickeners | |
| ES2187086T3 (en) | PERCARBOXILIC ACID SOLUTIONS THAT STABILIZE HARDNESS, PROCEDURE FOR PREPARATION AND USE. | |
| FI87465C (en) | Process for Preparation of Acrylic or / and Methacrylic Acid Water Soluble Polymeric or Copolymericates and Its Use | |
| WO2022083043A1 (en) | High yield value and highly transparent suspension stabilizer, preparation process, and application thereof | |
| RO115694B1 (en) | Bioartifcial material for implants | |
| CN106905488B (en) | A kind of preparation method of more carboxy starch composite high water absorption resins | |
| US5243006A (en) | Acrylic copolymer | |
| Chirila | Calcification of synthetic polymers functionalized with negatively ionizable groups: A critical review | |
| GB2277522A (en) | Denture base polymeric separating material | |
| CA2226131A1 (en) | Preparation of polymeric materials having cell poliferation-promoting properties | |
| JP2545512B2 (en) | Super absorbent polymer | |
| CN109810440A (en) | A kind of PMMA/SCTP composite fine powder and preparation method and composite bone cement using the same | |
| CN102250292A (en) | Thermoplastic animal protein and preparation method thereof | |
| JP3005667B2 (en) | Modified silk protein, method for producing the same, and osteosynthetic material | |
| CN110835381A (en) | Composite microsphere with three-layer core-shell structure and preparation method and composite bone cement using the same |