RO103684A2 - PRODUCTION METHOD OF IMMUNO-GLOBULIN A1(IgA1) - Google Patents
PRODUCTION METHOD OF IMMUNO-GLOBULIN A1(IgA1)Info
- Publication number
- RO103684A2 RO103684A2 RO13817389A RO13817389A RO103684A2 RO 103684 A2 RO103684 A2 RO 103684A2 RO 13817389 A RO13817389 A RO 13817389A RO 13817389 A RO13817389 A RO 13817389A RO 103684 A2 RO103684 A2 RO 103684A2
- Authority
- RO
- Romania
- Prior art keywords
- iga1
- globulin
- immuno
- production method
- per
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 abstract 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 2
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 abstract 2
- 235000019797 dipotassium phosphate Nutrition 0.000 abstract 2
- 229910000396 dipotassium phosphate Inorganic materials 0.000 abstract 2
- 238000010828 elution Methods 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 235000011148 calcium chloride Nutrition 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000011007 phosphoric acid Nutrition 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 abstract 1
- 235000019801 trisodium phosphate Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The process comprises defibrination with CaCl2 of plasma very high in IgA, and very low in IgG, for treatment with 25 g of (NH4)2SO4 per 100 ml at 4 deg.C. The centrifuged ppte is washed two hours with soln. of (NH4)2SO4 (25%, 25g per 100 ml of water), and buffered with Na3PO4/H3PO4, 0.03 M, pH = 5, containing 0.3 M of NaCl and 0.02 per cent of NaN3. Chromatography, and elution, with buffer K2HPO4, 0.02 M, pH = 8, and further chromatography, is followed by elution with 0.1 M NaCl in K2HPO4, 0.02 M, pH = 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO138173A RO103684B1 (en) | 1989-02-10 | 1989-02-10 | Production method of immuno-globulin a1(iga1) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO138173A RO103684B1 (en) | 1989-02-10 | 1989-02-10 | Production method of immuno-globulin a1(iga1) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO103684A2 true RO103684A2 (en) | 1991-12-09 |
| RO103684B1 RO103684B1 (en) | 1992-03-25 |
Family
ID=20123980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO138173A RO103684B1 (en) | 1989-02-10 | 1989-02-10 | Production method of immuno-globulin a1(iga1) |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO103684B1 (en) |
-
1989
- 1989-02-10 RO RO138173A patent/RO103684B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO103684B1 (en) | 1992-03-25 |
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