RO103684A2 - PRODUCTION METHOD OF IMMUNO-GLOBULIN A1(IgA1) - Google Patents
PRODUCTION METHOD OF IMMUNO-GLOBULIN A1(IgA1)Info
- Publication number
- RO103684A2 RO103684A2 RO13817389A RO13817389A RO103684A2 RO 103684 A2 RO103684 A2 RO 103684A2 RO 13817389 A RO13817389 A RO 13817389A RO 13817389 A RO13817389 A RO 13817389A RO 103684 A2 RO103684 A2 RO 103684A2
- Authority
- RO
- Romania
- Prior art keywords
- iga1
- globulin
- immuno
- production method
- per
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 abstract 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 2
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 abstract 2
- 235000019797 dipotassium phosphate Nutrition 0.000 abstract 2
- 229910000396 dipotassium phosphate Inorganic materials 0.000 abstract 2
- 238000010828 elution Methods 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 235000011148 calcium chloride Nutrition 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000011007 phosphoric acid Nutrition 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 abstract 1
- 235000019801 trisodium phosphate Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
The process comprises defibrination with CaCl2 of plasma very high in IgA, and very low in IgG, for treatment with 25 g of (NH4)2SO4 per 100 ml at 4 deg.C. The centrifuged ppte is washed two hours with soln. of (NH4)2SO4 (25%, 25g per 100 ml of water), and buffered with Na3PO4/H3PO4, 0.03 M, pH = 5, containing 0.3 M of NaCl and 0.02 per cent of NaN3. Chromatography, and elution, with buffer K2HPO4, 0.02 M, pH = 8, and further chromatography, is followed by elution with 0.1 M NaCl in K2HPO4, 0.02 M, pH = 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO138173A RO103684B1 (en) | 1989-02-10 | 1989-02-10 | Production method of immuno-globulin a1(iga1) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO138173A RO103684B1 (en) | 1989-02-10 | 1989-02-10 | Production method of immuno-globulin a1(iga1) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO103684A2 true RO103684A2 (en) | 1991-12-09 |
| RO103684B1 RO103684B1 (en) | 1992-03-25 |
Family
ID=20123980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO138173A RO103684B1 (en) | 1989-02-10 | 1989-02-10 | Production method of immuno-globulin a1(iga1) |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO103684B1 (en) |
-
1989
- 1989-02-10 RO RO138173A patent/RO103684B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO103684B1 (en) | 1992-03-25 |
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