RO100030B1 - Production method for (r.s.)-3-(2, 3-epoxypropoxy)-4-(n-morpholine)-1, 2, 5-thiadiazole - Google Patents

Production method for (r.s.)-3-(2, 3-epoxypropoxy)-4-(n-morpholine)-1, 2, 5-thiadiazole

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Publication number
RO100030B1
RO100030B1 RO135256A RO13525688A RO100030B1 RO 100030 B1 RO100030 B1 RO 100030B1 RO 135256 A RO135256 A RO 135256A RO 13525688 A RO13525688 A RO 13525688A RO 100030 B1 RO100030 B1 RO 100030B1
Authority
RO
Romania
Prior art keywords
thiadiazole
epoxypropoxy
morpholine
production method
morpholino
Prior art date
Application number
RO135256A
Other languages
Romanian (ro)
Other versions
RO100030A2 (en
Inventor
Steliana Cilianu
Teodor Burghelea
Corina Ilie
Gabriela Putina
Mariana-Simina Ionescu
Gebriela Ivona Pencu
Original Assignee
Institutul De Cercetari Chimico-Farmaceutice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institutul De Cercetari Chimico-Farmaceutice filed Critical Institutul De Cercetari Chimico-Farmaceutice
Priority to RO135256A priority Critical patent/RO100030B1/en
Publication of RO100030A2 publication Critical patent/RO100030A2/en
Publication of RO100030B1 publication Critical patent/RO100030B1/en

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Abstract

Inventia se refera la un proecdeu de obtinere a (R,S)-3-(2,3-epoxipropoxi)-4-(N-morfolino)-1,2,5-tiadiazolului prin reactia de eterificare a 3-hidroxi-4-(N-morfolino)-1,2,5-tiadiazolului sub forma de derivat sodat, cu epiclorhidrina, în solventi aprotici dipolari cu randamente de 56% si cu o purificare foarte buna (aproximativ 95%) care permite trecerea ca atare la faza urmatoare.The invention relates to a process for obtaining (R, S) -3- (2,3-epoxypropoxy) -4- (N-morpholino) -1,2,5-thiadiazole by the etherification reaction of 3-hydroxy- - (N-morpholino) -1,2,5-thiadiazole sodium salt with epichlorohydrin in dipolar aprotic solvents in 56% yields and with very good purification (approximately 95%) which allows the passage to phase Next.

RO135256A 1988-09-26 1988-09-26 Production method for (r.s.)-3-(2, 3-epoxypropoxy)-4-(n-morpholine)-1, 2, 5-thiadiazole RO100030B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RO135256A RO100030B1 (en) 1988-09-26 1988-09-26 Production method for (r.s.)-3-(2, 3-epoxypropoxy)-4-(n-morpholine)-1, 2, 5-thiadiazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO135256A RO100030B1 (en) 1988-09-26 1988-09-26 Production method for (r.s.)-3-(2, 3-epoxypropoxy)-4-(n-morpholine)-1, 2, 5-thiadiazole

Publications (2)

Publication Number Publication Date
RO100030A2 RO100030A2 (en) 1990-07-16
RO100030B1 true RO100030B1 (en) 1990-10-30

Family

ID=20122521

Family Applications (1)

Application Number Title Priority Date Filing Date
RO135256A RO100030B1 (en) 1988-09-26 1988-09-26 Production method for (r.s.)-3-(2, 3-epoxypropoxy)-4-(n-morpholine)-1, 2, 5-thiadiazole

Country Status (1)

Country Link
RO (1) RO100030B1 (en)

Also Published As

Publication number Publication date
RO100030A2 (en) 1990-07-16

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