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Application filed by Institutul De Cercetari Chimico-FarmaceuticefiledCriticalInstitutul De Cercetari Chimico-Farmaceutice
Priority to RO135256ApriorityCriticalpatent/RO100030B1/en
Publication of RO100030A2publicationCriticalpatent/RO100030A2/en
Publication of RO100030B1publicationCriticalpatent/RO100030B1/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Inventia se refera la un proecdeu de obtinere a (R,S)-3-(2,3-epoxipropoxi)-4-(N-morfolino)-1,2,5-tiadiazolului prin reactia de eterificare a 3-hidroxi-4-(N-morfolino)-1,2,5-tiadiazolului sub forma de derivat sodat, cu epiclorhidrina, în solventi aprotici dipolari cu randamente de 56% si cu o purificare foarte buna (aproximativ 95%) care permite trecerea ca atare la faza urmatoare.The invention relates to a process for obtaining (R, S) -3- (2,3-epoxypropoxy) -4- (N-morpholino) -1,2,5-thiadiazole by the etherification reaction of 3-hydroxy- - (N-morpholino) -1,2,5-thiadiazole sodium salt with epichlorohydrin in dipolar aprotic solvents in 56% yields and with very good purification (approximately 95%) which allows the passage to phase Next.
RO135256A1988-09-261988-09-26Production method for (r.s.)-3-(2, 3-epoxypropoxy)-4-(n-morpholine)-1, 2, 5-thiadiazole
RO100030B1
(en)
Process for the preparation of 7,16-dioxa-2 aza-10-0-cladinosyl-12-0 desosaminyl-4,5-dihydroxy-6-ethyl 3,5,9,11,13,15-hexamethylbicyclo (11.2.1) hexadeca-1 (2) -en-8-one