PT97061A - Metodo para a utilizacao de tenidap como inibidor da activacao de colagenase e da actividade de mieloperoxidase - Google Patents

Metodo para a utilizacao de tenidap como inibidor da activacao de colagenase e da actividade de mieloperoxidase

Info

Publication number
PT97061A
PT97061A PT97061A PT9706191A PT97061A PT 97061 A PT97061 A PT 97061A PT 97061 A PT97061 A PT 97061A PT 9706191 A PT9706191 A PT 9706191A PT 97061 A PT97061 A PT 97061A
Authority
PT
Portugal
Prior art keywords
colagenase
tenidap
myeloperoxidase
inhibitor
activation
Prior art date
Application number
PT97061A
Other languages
English (en)
Other versions
PT97061B (pt
Inventor
Warren Darrel Blackburn Jr
Leland David Loose
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT97061A publication Critical patent/PT97061A/pt
Publication of PT97061B publication Critical patent/PT97061B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT97061A 1990-03-19 1991-03-18 Metodo para a utilizacao de tenidap como inibidor da activacao de colagenase e da actividade de mieloperoxidase PT97061B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/495,868 US5008283A (en) 1990-03-19 1990-03-19 Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase

Publications (2)

Publication Number Publication Date
PT97061A true PT97061A (pt) 1991-10-31
PT97061B PT97061B (pt) 1998-07-31

Family

ID=23970312

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97061A PT97061B (pt) 1990-03-19 1991-03-18 Metodo para a utilizacao de tenidap como inibidor da activacao de colagenase e da actividade de mieloperoxidase

Country Status (14)

Country Link
US (1) US5008283A (pt)
EP (1) EP0448253A3 (pt)
JP (1) JPH04234815A (pt)
KR (1) KR930010581B1 (pt)
AU (2) AU625409B2 (pt)
CA (1) CA2038409C (pt)
HU (1) HUT60623A (pt)
IE (1) IE910860A1 (pt)
IL (1) IL97521A (pt)
MY (1) MY107235A (pt)
NZ (1) NZ237451A (pt)
PT (1) PT97061B (pt)
SG (1) SG48397A1 (pt)
ZA (1) ZA911979B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122534A (en) * 1991-02-08 1992-06-16 Pfizer Inc. Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
TW438798B (en) * 1992-10-07 2001-06-07 Pfizer 3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
ES2076106B1 (es) * 1993-08-26 1996-06-16 Pfizer Composiciones farmaceuticas a base de 2-oxindol-1-carboxamidas 3-sustituidas
US5795902A (en) * 1993-09-02 1998-08-18 Pfizer Inc. 3-substituted 2-oxindole-1 carboxamide pharmaceutical compositions
US5516699A (en) * 1994-02-16 1996-05-14 Institute Of Molecular Biology, Inc. Pyridinoline crosslinks as markers of periodontal and peri-implant disease activity
US5545656A (en) * 1995-04-05 1996-08-13 Pfizer Inc. 2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
US5827840A (en) * 1996-08-01 1998-10-27 The Research Foundation Of State University Of New York Promotion of wound healing by chemically-modified tetracyclines
AU4084599A (en) * 1998-05-18 1999-12-06 Oklahoma Medical Research Foundation Resveratrol inhibition of myeloperoxidase
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
JP2009529057A (ja) 2006-03-08 2009-08-13 コートリア・コーポレーシヨン Ｃｏｘ−関連胃損傷を予防するための非−選択的ｃｏｘ阻害剤との組み合わせ療法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
UA25898A1 (uk) * 1987-02-02 1999-02-26 Пфайзер Інк. Спосіб одержаhhя кристалічhої hатрієвої солі 5-хлор-3-(2-теhоїл)-2-оксііhдол-1-карбоксаміду
DE3852145T2 (de) * 1987-02-18 1995-04-06 Beecham Group Plc Indolderivate, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten.
US4861794A (en) * 1988-04-13 1989-08-29 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US4853409A (en) * 1988-04-13 1989-08-01 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function
DE3814504A1 (de) * 1988-04-29 1989-11-09 Bayer Ag (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5006547A (en) * 1990-03-19 1991-04-09 Pfizer Inc. Tenidap as an inhibitor of the release of elastase by neutrophils

Also Published As

Publication number Publication date
NZ237451A (en) 1997-02-24
JPH04234815A (ja) 1992-08-24
EP0448253A3 (en) 1992-04-01
EP0448253A2 (en) 1991-09-25
SG48397A1 (en) 1998-04-17
KR910016326A (ko) 1991-11-05
HU910872D0 (en) 1991-09-30
PT97061B (pt) 1998-07-31
IL97521A (en) 1995-12-31
AU637745B2 (en) 1993-06-03
US5008283A (en) 1991-04-16
KR930010581B1 (ko) 1993-10-30
AU1957492A (en) 1992-09-10
AU7358791A (en) 1991-12-12
IL97521A0 (en) 1992-06-21
MY107235A (en) 1995-10-31
AU625409B2 (en) 1992-07-09
HUT60623A (en) 1992-10-28
CA2038409C (en) 1995-01-24
ZA911979B (en) 1992-10-28
IE910860A1 (en) 1991-09-25

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910710

FG3A Patent granted, date of granting

Effective date: 19980415

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991031