PT89935A - PROCESS FOR THE PREPARATION OF NEW CEFEM COMPOUNDS - Google Patents
PROCESS FOR THE PREPARATION OF NEW CEFEM COMPOUNDSInfo
- Publication number
- PT89935A PT89935A PT89935A PT8993589A PT89935A PT 89935 A PT89935 A PT 89935A PT 89935 A PT89935 A PT 89935A PT 8993589 A PT8993589 A PT 8993589A PT 89935 A PT89935 A PT 89935A
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- preparation
- pharmaceutically acceptable
- amino
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
A compound of the formula : <CHEM> wherein R<1> is amino or a protected amino group, R<2> is an organic group, R<3> is hydrogen, lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl, protected amino(lower)alkyl or an imino protective group, R<4> is hydrogen, lower alkyl or lower alkylthio, A is lower alkylene which may be substituted with suitable substituent(s) and Z is N or CH, and a pharmaceutically acceptable salt thereof, processes for its preparation and pharmaceutical compositions comprising them or a pharmaceutically acceptable salt thereof in admixture with pharmaceutically acceptable carriers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888805642A GB8805642D0 (en) | 1988-03-09 | 1988-03-09 | New cephem compounds & processes for preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT89935A true PT89935A (en) | 1989-11-10 |
| PT89935B PT89935B (en) | 1994-05-31 |
Family
ID=10633141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT89935A PT89935B (en) | 1988-03-09 | 1989-03-08 | PROCESS FOR THE PREPARATION OF NEW CEFEM COMPOUNDS |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0332156B1 (en) |
| JP (1) | JP2827260B2 (en) |
| KR (1) | KR890014561A (en) |
| CN (1) | CN1036959A (en) |
| AT (1) | ATE146476T1 (en) |
| AU (1) | AU617154B2 (en) |
| DE (1) | DE68927554D1 (en) |
| DK (1) | DK113289A (en) |
| FI (1) | FI891087A (en) |
| GB (1) | GB8805642D0 (en) |
| HU (1) | HUT49887A (en) |
| IL (1) | IL89454A0 (en) |
| NO (1) | NO890996L (en) |
| NZ (1) | NZ228254A (en) |
| OA (1) | OA09239A (en) |
| PH (1) | PH25911A (en) |
| PT (1) | PT89935B (en) |
| RU (1) | RU1804462C (en) |
| ZA (1) | ZA891622B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215982A (en) * | 1989-11-10 | 1993-06-01 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| EP0517041A1 (en) * | 1991-06-07 | 1992-12-09 | Fujisawa Pharmaceutical Co., Ltd. | New Cephem Compounds |
| JPH09110877A (en) * | 1995-10-17 | 1997-04-28 | Katayama Seiyakushiyo:Kk | Cephem compound, its production and antibacterial agent containing the compound |
| AUPN955596A0 (en) * | 1996-04-30 | 1996-05-23 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| WO1998045290A1 (en) * | 1997-04-04 | 1998-10-15 | Tokuyama Corporation | 2-aminothiazoleacetamide derivatives |
| CN1852715A (en) * | 2003-09-18 | 2006-10-25 | 安斯泰来制药有限公司 | Cephem compounds |
| WO2011061679A1 (en) | 2009-11-23 | 2011-05-26 | Pfizer Inc. | Imidazo-pyrazoles as gpr119 inhibitors |
| US9751894B2 (en) | 2015-12-10 | 2017-09-05 | Naeja-Rgm Pharmaceuticals Inc. | Cephem compounds, their production and use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331666A (en) * | 1979-05-11 | 1982-05-25 | Farmitalia Carlo Erba S.P.A. | 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid |
| EP0062321B1 (en) * | 1981-04-03 | 1989-03-01 | Fujisawa Pharmaceutical Co., Ltd. | New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds |
| AU8808882A (en) * | 1982-01-19 | 1983-03-17 | Eli Lilly And Company | Thieno and furopyridinium-substituted cephalosporin derivatives |
| DE3336757A1 (en) * | 1983-10-08 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
| PH22107A (en) * | 1984-06-07 | 1988-06-01 | Takeda Chemical Industries Ltd | 3-pyrazolo(1,5-a)pyrdinium cephem compounds |
| US4929612A (en) * | 1987-04-17 | 1990-05-29 | Eisai Co., Ltd. | Thiadiazolylacetamide cephem derivatives |
-
1988
- 1988-03-09 GB GB888805642A patent/GB8805642D0/en active Pending
-
1989
- 1989-02-27 PH PH38249A patent/PH25911A/en unknown
- 1989-03-02 ZA ZA891622A patent/ZA891622B/en unknown
- 1989-03-02 IL IL89454A patent/IL89454A0/en unknown
- 1989-03-06 AU AU31017/89A patent/AU617154B2/en not_active Ceased
- 1989-03-07 NZ NZ228254A patent/NZ228254A/en unknown
- 1989-03-07 RU SU894613719A patent/RU1804462C/en active
- 1989-03-08 EP EP89104048A patent/EP0332156B1/en not_active Expired - Lifetime
- 1989-03-08 NO NO89890996A patent/NO890996L/en unknown
- 1989-03-08 FI FI891087A patent/FI891087A/en not_active Application Discontinuation
- 1989-03-08 DE DE68927554T patent/DE68927554D1/en not_active Expired - Lifetime
- 1989-03-08 HU HU891142A patent/HUT49887A/en unknown
- 1989-03-08 AT AT89104048T patent/ATE146476T1/en active
- 1989-03-08 KR KR1019890002822A patent/KR890014561A/en not_active Application Discontinuation
- 1989-03-08 PT PT89935A patent/PT89935B/en not_active IP Right Cessation
- 1989-03-08 DK DK113289A patent/DK113289A/en not_active Application Discontinuation
- 1989-03-09 OA OA59539A patent/OA09239A/en unknown
- 1989-03-09 JP JP1057646A patent/JP2827260B2/en not_active Expired - Lifetime
- 1989-03-09 CN CN89101255A patent/CN1036959A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0332156A3 (en) | 1991-10-16 |
| AU3101789A (en) | 1989-09-14 |
| NO890996D0 (en) | 1989-03-08 |
| PH25911A (en) | 1991-12-19 |
| FI891087A (en) | 1989-09-10 |
| ZA891622B (en) | 1989-11-29 |
| DE68927554D1 (en) | 1997-01-30 |
| IL89454A0 (en) | 1989-09-10 |
| RU1804462C (en) | 1993-03-23 |
| HUT49887A (en) | 1989-11-28 |
| GB8805642D0 (en) | 1988-04-07 |
| ATE146476T1 (en) | 1997-01-15 |
| DK113289A (en) | 1989-09-10 |
| AU617154B2 (en) | 1991-11-21 |
| JP2827260B2 (en) | 1998-11-25 |
| PT89935B (en) | 1994-05-31 |
| JPH0215091A (en) | 1990-01-18 |
| NZ228254A (en) | 1990-08-28 |
| OA09239A (en) | 1992-06-30 |
| NO890996L (en) | 1989-09-11 |
| EP0332156A2 (en) | 1989-09-13 |
| KR890014561A (en) | 1989-10-24 |
| DK113289D0 (en) | 1989-03-08 |
| FI891087A0 (en) | 1989-03-08 |
| CN1036959A (en) | 1989-11-08 |
| EP0332156B1 (en) | 1996-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19931123 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19950531 |