PT87702A - PROCESS FOR PREPARING AXAZOLIDIN-2-ONE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS - Google Patents
PROCESS FOR PREPARING AXAZOLIDIN-2-ONE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTSInfo
- Publication number
- PT87702A PT87702A PT87702A PT8770288A PT87702A PT 87702 A PT87702 A PT 87702A PT 87702 A PT87702 A PT 87702A PT 8770288 A PT8770288 A PT 8770288A PT 87702 A PT87702 A PT 87702A
- Authority
- PT
- Portugal
- Prior art keywords
- axazolidin
- preparing
- pharmaceutically
- derivatives useful
- hypoglycemic agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Oxazolidin-2-one derivs. of formula (I), corresp. pharmaceutically-acceptable acid addn. salt or pharmaceutically-acceptable cationic salt are new. Rb is (i), (ii) (iii) or (iv), W is S or O; X, X' is H, Cl, F or CF3; Y is -COOR1, -CON(R1)CH2CONR3R3, gp. (v) or vi), Ra, R1, R2, R3 are H, CH3, R4 is CH3 or CF3. For pharmaceutically-acceptable acid addn. salt, Y is gp. (v) or Rb is gp. (iii). For pharmaceutically-acceptable cationic salt y is -COOH or gp. (vi). - Also claimed is an optically active cpd. of formula (I) and use of cpd. (I) as a medicament for the treatment of hyperglycemia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1987/001356 WO1988009661A1 (en) | 1987-06-10 | 1987-06-10 | Oxazolidin-2-one derivatives as hypoglycemic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
PT87702A true PT87702A (en) | 1988-07-01 |
PT87702B PT87702B (en) | 1992-10-30 |
Family
ID=22202413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT87702A PT87702B (en) | 1987-06-10 | 1988-06-09 | PROCESS FOR THE PREPARATION OF UXO OXAZOLIDIN-2-ONA DERIVATIVES AS HYPOGLYCEMIC AGENTS |
Country Status (21)
Country | Link |
---|---|
US (1) | US4968707A (en) |
EP (1) | EP0294995B1 (en) |
JP (1) | JPS649979A (en) |
KR (1) | KR900007313B1 (en) |
AT (1) | ATE82284T1 (en) |
AU (1) | AU585196B2 (en) |
CA (1) | CA1305152C (en) |
DE (1) | DE3875806T2 (en) |
DK (1) | DK313588A (en) |
ES (1) | ES2045116T3 (en) |
FI (1) | FI89479C (en) |
GR (1) | GR3007059T3 (en) |
HU (1) | HU203330B (en) |
IE (1) | IE62029B1 (en) |
IL (1) | IL86603A (en) |
MY (1) | MY103297A (en) |
NO (1) | NO171978C (en) |
NZ (1) | NZ224957A (en) |
PT (1) | PT87702B (en) |
WO (1) | WO1988009661A1 (en) |
ZA (1) | ZA884114B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02167224A (en) * | 1988-09-13 | 1990-06-27 | Tanabe Seiyaku Co Ltd | Antilipemic agent |
US5356908A (en) * | 1989-04-21 | 1994-10-18 | E. I. Du Pont De Nemours And Company | Fungicidal oxazolidinones |
WO1991003474A1 (en) * | 1989-08-29 | 1991-03-21 | Pfizer Inc. | Hypoglycemic thiazolidinedione derivatives |
US5068342A (en) * | 1989-10-27 | 1991-11-26 | American Home Products Corporation | 5-[(1- and 2-naphthalenyl)thio and sulfonyl]-2,4-thiazolidinediones and derivatives thereof |
CA2083891A1 (en) * | 1991-12-03 | 1993-06-04 | Angus Murray Macleod | Heterocyclic compounds, compositions containing them and their use in therapy |
UA27467C2 (en) * | 1992-04-07 | 2000-09-15 | Пфайзер Інк. | Indole derivatives as 5-ht1 agonists and intermediates |
ATE185564T1 (en) * | 1992-08-31 | 1999-10-15 | Sankyo Co | OXAZOLIDINE DERIVATIVES HAVING ANTIDIABETIC AND ANTI-OBESITY PROPERTIES, THEIR PREPARATION AND THERAPEUTIC USE |
KR0173145B1 (en) * | 1993-04-07 | 1999-02-01 | 고바야시 유키오 | Thiazolidine derivative and pharmaceutical composition containing the same |
US5629200A (en) * | 1993-11-18 | 1997-05-13 | Daicel Chemical Industries, Ltd. | Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation |
CA2145257A1 (en) * | 1994-03-23 | 1995-09-24 | Takashi Fujita | Thiazolidine and oxazolidine derivatives, their preparation and their medical use |
ES2421511T3 (en) | 2001-12-21 | 2013-09-03 | X Ceptor Therapeutics Inc | LXR modulators |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
DOP2005000123A (en) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | CETP INHIBITORS |
ES2324794T3 (en) * | 2004-12-21 | 2009-08-14 | Gilead Sciences Inc | IMIDAZO (4,5-C) COMPONENT PYRIDINE AND ANTIVIRAL TREATMENT METHOD. |
AR057218A1 (en) * | 2005-12-15 | 2007-11-21 | Astra Ab | OXAZOLIDINONE COMPOUNDS AND THEIR USE AS PONTENCIATORS OF THE METABOTROPIC GLUTAMATE RECEIVER |
EP2029560B1 (en) | 2005-12-30 | 2013-04-24 | Merck Sharp & Dohme Corp. | 1,3-oxazolidin-2-one derivatives useeful as cetp inhibitors |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2909467A (en) * | 1958-07-09 | 1959-10-20 | Us Vitamin Pharm Corp | 3-(d-alpha-methylphenethyl)-5-methyl-1, 3-oxazolidine-2, 4-dione |
JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
DD153682A1 (en) * | 1978-10-19 | 1982-01-27 | Horst Bercher | PROCESS FOR PRODUCING NEW ALKANOLAMINE |
DE3162756D1 (en) * | 1980-05-22 | 1984-04-26 | Beecham Group Plc | Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions |
SG56656G (en) * | 1980-07-28 | 1987-03-27 | Pfizer | Hypoglycemic 5-substituted oxazolidine-2, 4-diones |
US4407811A (en) * | 1981-01-02 | 1983-10-04 | Pfizer Inc. | Hypoglycemic 5-substituted oxazolidine-2,4-diones |
ES8400116A1 (en) * | 1981-10-13 | 1983-10-16 | Pfizer | Oxazolidinedione derivatives. |
GR78120B (en) * | 1982-03-01 | 1984-09-26 | Pfizer | |
JPS58183676A (en) * | 1982-04-19 | 1983-10-26 | Takeda Chem Ind Ltd | Oxazole derivative |
US4430337A (en) * | 1982-06-23 | 1984-02-07 | Pfizer Inc. | Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity |
US4617312A (en) * | 1983-01-17 | 1986-10-14 | Pfizer Inc. | Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones |
DE3476386D1 (en) * | 1983-11-02 | 1989-03-02 | Beecham Group Plc | MORPHOLINE DERIVATIVES |
EP0142102B1 (en) * | 1983-11-04 | 1987-09-23 | Beecham Group Plc | Tertiary amines |
CA1249992A (en) * | 1983-11-10 | 1989-02-14 | Marcel Muller | Oxazolidines |
GB8412862D0 (en) * | 1984-05-19 | 1984-06-27 | Beecham Group Plc | Compounds |
GB8418657D0 (en) * | 1984-07-21 | 1984-08-22 | Beecham Group Plc | Compounds |
WO1986002073A1 (en) * | 1984-10-03 | 1986-04-10 | Takeda Chemical Industries, Ltd. | Thiazolidinedione derivatives, process for their preparation, and pharmaceutical composition containing same |
DE3438839A1 (en) * | 1984-10-19 | 1986-04-24 | Schering AG, 1000 Berlin und 4709 Bergkamen | PHARMACEUTICAL PREPARATIONS |
AR240698A1 (en) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Process for the preparation of 5-(4-(2-(5-ethyl-2-pyridil)-ethoxy)benzyl)-2,4-thiazolodinedione and their salts |
US4738972A (en) * | 1985-05-21 | 1988-04-19 | Pfizer Inc. | Hypoglycemic thiazolidinediones |
JPH06779B2 (en) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | Thiazolidione derivative and pharmaceutical composition comprising the same |
US4812570A (en) * | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
US4873255A (en) * | 1987-02-04 | 1989-10-10 | Sankyo Company Limited | Thiazolidinone derivatives, their preparation and their use |
EP0295828A1 (en) * | 1987-06-13 | 1988-12-21 | Beecham Group Plc | Novel compounds |
US4791125A (en) * | 1987-12-02 | 1988-12-13 | Pfizer Inc. | Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents |
-
1987
- 1987-06-10 HU HU874223A patent/HU203330B/en not_active IP Right Cessation
- 1987-06-10 US US07/460,848 patent/US4968707A/en not_active Expired - Fee Related
- 1987-06-10 WO PCT/US1987/001356 patent/WO1988009661A1/en active IP Right Grant
-
1988
- 1988-06-01 EP EP88304976A patent/EP0294995B1/en not_active Expired - Lifetime
- 1988-06-01 ES ES88304976T patent/ES2045116T3/en not_active Expired - Lifetime
- 1988-06-01 DE DE8888304976T patent/DE3875806T2/en not_active Expired - Fee Related
- 1988-06-01 AT AT88304976T patent/ATE82284T1/en active
- 1988-06-02 IL IL86603A patent/IL86603A/en not_active IP Right Cessation
- 1988-06-06 MY MYPI88000601A patent/MY103297A/en unknown
- 1988-06-07 JP JP63139787A patent/JPS649979A/en active Granted
- 1988-06-08 CA CA000568902A patent/CA1305152C/en not_active Expired - Fee Related
- 1988-06-09 ZA ZA884114A patent/ZA884114B/en unknown
- 1988-06-09 DK DK313588A patent/DK313588A/en not_active Application Discontinuation
- 1988-06-09 AU AU17534/88A patent/AU585196B2/en not_active Ceased
- 1988-06-09 PT PT87702A patent/PT87702B/en not_active IP Right Cessation
- 1988-06-09 NZ NZ224957A patent/NZ224957A/en unknown
- 1988-06-09 KR KR1019880006908A patent/KR900007313B1/en not_active IP Right Cessation
- 1988-06-09 IE IE173488A patent/IE62029B1/en not_active IP Right Cessation
-
1989
- 1989-02-08 NO NO89890529A patent/NO171978C/en unknown
- 1989-12-05 FI FI895815A patent/FI89479C/en not_active IP Right Cessation
-
1993
- 1993-02-11 GR GR930400291T patent/GR3007059T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI895815A0 (en) | 1989-12-05 |
DE3875806T2 (en) | 1993-04-08 |
EP0294995B1 (en) | 1992-11-11 |
KR900007313B1 (en) | 1990-10-08 |
GR3007059T3 (en) | 1993-07-30 |
NO171978C (en) | 1993-05-26 |
IL86603A (en) | 1992-09-06 |
MY103297A (en) | 1993-05-29 |
NO890529D0 (en) | 1989-02-08 |
WO1988009661A1 (en) | 1988-12-15 |
HU203330B (en) | 1991-07-29 |
ZA884114B (en) | 1990-02-28 |
HUT53623A (en) | 1990-11-28 |
DE3875806D1 (en) | 1992-12-17 |
FI89479C (en) | 1993-10-11 |
US4968707A (en) | 1990-11-06 |
KR890000447A (en) | 1989-03-14 |
NO171978B (en) | 1993-02-15 |
DK313588D0 (en) | 1988-06-09 |
PT87702B (en) | 1992-10-30 |
ES2045116T3 (en) | 1994-01-16 |
FI89479B (en) | 1993-06-30 |
AU1753488A (en) | 1988-12-15 |
NZ224957A (en) | 1990-03-27 |
IL86603A0 (en) | 1988-11-30 |
DK313588A (en) | 1989-02-10 |
EP0294995A1 (en) | 1988-12-14 |
IE881734L (en) | 1988-12-10 |
JPS649979A (en) | 1989-01-13 |
NO890529L (en) | 1989-02-08 |
CA1305152C (en) | 1992-07-14 |
ATE82284T1 (en) | 1992-11-15 |
AU585196B2 (en) | 1989-06-08 |
JPH0448791B2 (en) | 1992-08-07 |
IE62029B1 (en) | 1994-12-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT87702A (en) | PROCESS FOR PREPARING AXAZOLIDIN-2-ONE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | |
NO166448C (en) | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE TIAZOLIDE INDIANS. | |
FI902258A0 (en) | Process for the preparation of pharmacologically active 13,14-dihydro-17-phenyl-18,19,20-trinor-PGF2 alkyl esters | |
ES2044878T3 (en) | A PROCESS FOR THE PREPARATION OF BENZIMIDAZOLE DERIVATIVES. | |
FI922850A0 (en) | Process for preparing a virus inactivated blood product | |
HUT57044A (en) | Process for producing phrmaceutical compositions having n-neuropeptide antagonistic effect and comprising imidazolyl alkylguanidine derivatives | |
DE3873578D1 (en) | USE OF TETRAHYDROBENZ (C, D) INDOL-6-CARBOXAMIDES FOR THE PRODUCTION OF MEDICINAL PRODUCTS FOR THE TREATMENT OF ANXIETIES. | |
SE8704979D0 (en) | NEW FURANURONIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE | |
HUT46214A (en) | Process for producing medical preparation suitable for treatment of peptic ulcer | |
ATE181503T1 (en) | USE OF IDAZOXAN AND DERIVATIVES FOR THE PRODUCTION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF PARKINSONISM AND ITS EVOLUTION | |
DK149492C (en) | ANALOGY PROCEDURE FOR PREPARING 3-ALKYLTHIO-2-ACYLOXYPROPYL-2'-TRIMETHYL-AMMONIOETHYL-PHOSPHATES | |
PT96828A (en) | METHOD FOR PREPARING AN AGENT FOR DIABETIC GANGRENA THERAPY CONTAINING BLOOD COAGULATION FACTOR XIII | |
ATE212842T1 (en) | QUINOXALINE DERIVATIVES FOR THE TREATMENT OF TINNITUS | |
KR900004730A (en) | 4- [4- (3-benzisothiazolyl) -1-piperazinyl] butyl crosslinked bicyclic imide as an antipsychotic | |
HUT45989A (en) | Process for production of derivatives of 1,4-dihydropiridine and medical preparatives containing them as active substance | |
ATE66811T1 (en) | APPLICATION OF N-((1-AETHYL-2-PYRROLIDINYL)METHYL>METHOXY-5-SULFAMOYLBENZAMIDE FOR STERILITY TREATMENT. | |
ATE81465T1 (en) | USE OF 2-OXO-IMIDAZOLIDINE DERIVATIVES IN THE TREATMENT OF KIDNEY DISEASES. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19920401 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19971031 |