PT74320A - Process for preparing new ammonium salts pharmaceutical preparations containing these compounds and their use - Google Patents

Process for preparing new ammonium salts pharmaceutical preparations containing these compounds and their use

Info

Publication number
PT74320A
PT74320A PT74320A PT7432082A PT74320A PT 74320 A PT74320 A PT 74320A PT 74320 A PT74320 A PT 74320A PT 7432082 A PT7432082 A PT 7432082A PT 74320 A PT74320 A PT 74320A
Authority
PT
Portugal
Prior art keywords
substd
opt
compounds
ammonium salts
pharmaceutical preparations
Prior art date
Application number
PT74320A
Other languages
Portuguese (pt)
Other versions
PT74320B (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FI814153A priority Critical patent/FI814153L/en
Priority to NO814461A priority patent/NO814461L/en
Priority to JP56216090A priority patent/JPS58118584A/en
Priority to DD82236741A priority patent/DD202160A5/en
Priority to AU79623/82A priority patent/AU7962382A/en
Priority to GB08201459A priority patent/GB2113203B/en
Priority to ZA82327A priority patent/ZA82327B/en
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to PT74320A priority patent/PT74320B/en
Publication of PT74320A publication Critical patent/PT74320A/en
Publication of PT74320B publication Critical patent/PT74320B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Benzothiazine salts of formula (I) are new. R is opt. substd. heteroaryl. R1 is H or opt. substd. aliphatic hydrocarbyl. AmH+ is the cation derived from a dialkyl-, di(hydroxyalkyl)- or tri(hydroxyalkyl)-amine, the alkyls being up to 7C. Ring A is opt. substd. (I) are made by reacting the corresp. 4-hydroxy cpd. (free acid) with Am or its salt. (I) are useful as antiinflammatory and analgesic agents. Compared with the known free acids and inorganic salts, they show quicker and more complete resorption so are effective at lower doses, e.g. 75-150 mg. for a 70 kg subject. Also (I) are not hydroscopic. (Provisional Basic previously advised in Week K05).
PT74320A 1981-12-23 1982-01-21 Process for preparing new ammonium salts pharmaceutical preparations containing these compounds and their use PT74320B (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FI814153A FI814153L (en) 1981-12-23 1981-12-23 NYA AMMONIUMSALTER, FOERFARANDE FOER DERAS FRAMSTAELLNING, DESSA INNEHAOLLANDE PHARMACEUTICAL PREPAROCH DERAS ANVAENDNING
NO814461A NO814461L (en) 1981-12-23 1981-12-29 NEW AMMONIUM SALTS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE
JP56216090A JPS58118584A (en) 1981-12-23 1981-12-29 Novel ammonium salt and manufacture, pharmaceutical medicine and use
DD82236741A DD202160A5 (en) 1981-12-23 1982-01-14 METHOD FOR THE PRODUCTION OF AMMONIUM SALTS OF SUBSTITUTED 3,4-DIHYDRO-2H-1,2-BENZOTHIAZINE-1,1-DIOXIDES
AU79623/82A AU7962382A (en) 1981-12-23 1982-01-19 Ammonium salts of substituted 3,4-dihydro-2h-1,2- benzothiazine-1,1-dioxides
GB08201459A GB2113203B (en) 1981-12-23 1982-01-19 Ammonium salts of 4-hydroxy-1,2-benzothiazine-1,1-dioxides and pharmaceutical preparations containing them
ZA82327A ZA82327B (en) 1981-12-23 1982-01-19 Novel ammonium salts,processes for their manufacture,pharmaceutical preparations containing them,and their use
PT74320A PT74320B (en) 1981-12-23 1982-01-21 Process for preparing new ammonium salts pharmaceutical preparations containing these compounds and their use

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
FI814153A FI814153L (en) 1981-12-23 1981-12-23 NYA AMMONIUMSALTER, FOERFARANDE FOER DERAS FRAMSTAELLNING, DESSA INNEHAOLLANDE PHARMACEUTICAL PREPAROCH DERAS ANVAENDNING
NO814461A NO814461L (en) 1981-12-23 1981-12-29 NEW AMMONIUM SALTS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE
JP56216090A JPS58118584A (en) 1981-12-23 1981-12-29 Novel ammonium salt and manufacture, pharmaceutical medicine and use
DD82236741A DD202160A5 (en) 1981-12-23 1982-01-14 METHOD FOR THE PRODUCTION OF AMMONIUM SALTS OF SUBSTITUTED 3,4-DIHYDRO-2H-1,2-BENZOTHIAZINE-1,1-DIOXIDES
AU79623/82A AU7962382A (en) 1981-12-23 1982-01-19 Ammonium salts of substituted 3,4-dihydro-2h-1,2- benzothiazine-1,1-dioxides
GB08201459A GB2113203B (en) 1981-12-23 1982-01-19 Ammonium salts of 4-hydroxy-1,2-benzothiazine-1,1-dioxides and pharmaceutical preparations containing them
ZA82327A ZA82327B (en) 1981-12-23 1982-01-19 Novel ammonium salts,processes for their manufacture,pharmaceutical preparations containing them,and their use
PT74320A PT74320B (en) 1981-12-23 1982-01-21 Process for preparing new ammonium salts pharmaceutical preparations containing these compounds and their use

Publications (2)

Publication Number Publication Date
PT74320A true PT74320A (en) 1982-02-01
PT74320B PT74320B (en) 1984-08-02

Family

ID=34397300

Family Applications (1)

Application Number Title Priority Date Filing Date
PT74320A PT74320B (en) 1981-12-23 1982-01-21 Process for preparing new ammonium salts pharmaceutical preparations containing these compounds and their use

Country Status (8)

Country Link
JP (1) JPS58118584A (en)
AU (1) AU7962382A (en)
DD (1) DD202160A5 (en)
FI (1) FI814153L (en)
GB (1) GB2113203B (en)
NO (1) NO814461L (en)
PT (1) PT74320B (en)
ZA (1) ZA82327B (en)

Also Published As

Publication number Publication date
GB2113203A (en) 1983-08-03
NO814461L (en) 1983-06-30
GB2113203B (en) 1985-07-31
ZA82327B (en) 1982-12-29
AU7962382A (en) 1983-07-28
JPS58118584A (en) 1983-07-14
PT74320B (en) 1984-08-02
FI814153L (en) 1983-06-24
DD202160A5 (en) 1983-08-31

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