PT67452A - Psycho-stimulant, vigilance increasing 10-bromo-vincamine - used for treating cerebral insufficiency - Google Patents

Psycho-stimulant, vigilance increasing 10-bromo-vincamine - used for treating cerebral insufficiency

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Publication number
PT67452A
PT67452A PT6745277A PT6745277A PT67452A PT 67452 A PT67452 A PT 67452A PT 6745277 A PT6745277 A PT 6745277A PT 6745277 A PT6745277 A PT 6745277A PT 67452 A PT67452 A PT 67452A
Authority
PT
Portugal
Prior art keywords
bromo
treating cerebral
vincamine
psycho
stimulant
Prior art date
Application number
PT6745277A
Other languages
French (fr)
Portuguese (pt)
Other versions
PT67452B (en
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Priority to PT6745277A priority Critical patent/PT67452B/en
Publication of PT67452A publication Critical patent/PT67452A/en
Publication of PT67452B publication Critical patent/PT67452B/en

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Abstract

10-Bromovincamine (I) and its acid addn. salts and 10-bormo-epivincamine are new, in optically active or racemic form. (I) is a psychostimulant and agent for increasing vigilance. It may be used for treating cerebral insuficciency at a daily dose of 10-50 mg. In an example, (3S, 14S, 16S)-(I) was prepd. from vincadifformine via the novel intermediates 15-bromo-vincadifformine and methyl 5-bromo-1,2-didehydro-3-hydroxy-aspidospermidine-3-carboxylate 9-oxide by bromination, reaction with m-chloroperbenzoic acid and heating in presence of PPh3 and acetic acid.
PT6745277A 1977-12-23 1977-12-23 PROCESS FOR THE PREPARATION OF NEW ORGANIC COMPOUNDS WITH PHARMACEUTICAL EFFECT PT67452B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PT6745277A PT67452B (en) 1977-12-23 1977-12-23 PROCESS FOR THE PREPARATION OF NEW ORGANIC COMPOUNDS WITH PHARMACEUTICAL EFFECT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT6745277A PT67452B (en) 1977-12-23 1977-12-23 PROCESS FOR THE PREPARATION OF NEW ORGANIC COMPOUNDS WITH PHARMACEUTICAL EFFECT

Publications (2)

Publication Number Publication Date
PT67452A true PT67452A (en) 1978-01-01
PT67452B PT67452B (en) 1979-09-20

Family

ID=20082182

Family Applications (1)

Application Number Title Priority Date Filing Date
PT6745277A PT67452B (en) 1977-12-23 1977-12-23 PROCESS FOR THE PREPARATION OF NEW ORGANIC COMPOUNDS WITH PHARMACEUTICAL EFFECT

Country Status (1)

Country Link
PT (1) PT67452B (en)

Also Published As

Publication number Publication date
PT67452B (en) 1979-09-20

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