PT3580330T - Method for generating t cells progenitors - Google Patents
Method for generating t cells progenitorsInfo
- Publication number
- PT3580330T PT3580330T PT187045513T PT18704551T PT3580330T PT 3580330 T PT3580330 T PT 3580330T PT 187045513 T PT187045513 T PT 187045513T PT 18704551 T PT18704551 T PT 18704551T PT 3580330 T PT3580330 T PT 3580330T
- Authority
- PT
- Portugal
- Prior art keywords
- generating
- cells progenitors
- progenitors
- cells
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305161 | 2017-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3580330T true PT3580330T (en) | 2022-12-06 |
Family
ID=58185453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT187045513T PT3580330T (en) | 2017-02-13 | 2018-02-12 | Method for generating t cells progenitors |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US20200046767A1 (en) |
| EP (2) | EP4067482A1 (en) |
| JP (2) | JP7164798B2 (en) |
| KR (1) | KR20190117550A (en) |
| CN (1) | CN110506110A (en) |
| AU (1) | AU2018217404B2 (en) |
| BR (1) | BR112019016672A8 (en) |
| CA (1) | CA3053294A1 (en) |
| DK (1) | DK3580330T3 (en) |
| ES (1) | ES2931530T3 (en) |
| HU (1) | HUE060548T2 (en) |
| IL (1) | IL268641A (en) |
| MA (1) | MA47541A (en) |
| PL (1) | PL3580330T3 (en) |
| PT (1) | PT3580330T (en) |
| WO (1) | WO2018146297A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE060548T2 (en) * | 2017-02-13 | 2023-03-28 | Hopitaux Paris Assist Publique | Method for generating t cells progenitors |
| CA3077344A1 (en) * | 2017-09-29 | 2019-04-04 | Regents Of The University Of Minnesota | Methods of making, expanding, and using a human progenitor t cell |
| US20220403326A1 (en) * | 2019-11-14 | 2022-12-22 | Peter William ZANDSTRA | Media formulations and methods for producing progenitor t cells |
| WO2021200901A1 (en) * | 2020-03-31 | 2021-10-07 | 国立大学法人京都大学 | T cell progenitor production method |
| WO2022248354A1 (en) * | 2021-05-25 | 2022-12-01 | Universiteit Gent | Generating t cell precursors via agonizing tumor necrosis factor receptor 2 |
| WO2023079082A1 (en) | 2021-11-04 | 2023-05-11 | Aphp (Assistance Publique - Hôpitaux De Paris) | Method for generating nk cells |
| FR3130843A1 (en) * | 2021-12-21 | 2023-06-23 | Universite Claude Bernard Lyon 1 | T-lymphocyte progenitor cell expressing a transgene of interest in a regulated manner |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093531A (en) | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
| JP2001525176A (en) | 1997-12-04 | 2001-12-11 | デューク・ユニバーシティー | Methods for isolating and using CD7 + CD34-LIN-hematopoietic cells |
| WO2009097140A1 (en) | 2008-01-30 | 2009-08-06 | Memorial Sloan-Kettering Cancer Center | Methods for off -the -shelf tumor immunotherapy using allogeneic t-cell precursors |
| CN102186970A (en) | 2008-09-12 | 2011-09-14 | 克里奥普拉斯低温生物有限公司 | Ischemic tissue cell therapy |
| CA2742622C (en) | 2008-11-07 | 2018-02-27 | Juan Carlos Zuniga-Pfluecker | Human progenitor t-cells |
| WO2011068962A1 (en) | 2009-12-03 | 2011-06-09 | The University Of Utah Research Foundation | Methods for generating t lymphocytes from hematopoietic stem cells |
| WO2011127470A1 (en) | 2010-04-09 | 2011-10-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
| US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| AU2012347534B2 (en) | 2011-12-08 | 2018-01-25 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| US20150352180A1 (en) | 2013-01-11 | 2015-12-10 | The Trustee Of The University Of Pennsylvania | Notch Ligand Bound Biocompatible Substrates And Their Use In Bone Formation |
| AU2014296059B2 (en) | 2013-08-02 | 2020-12-10 | The Regents Of The University Of California | Engineering antiviral T cell immunity through stem cells and chimeric antigen receptors |
| WO2015099134A1 (en) | 2013-12-26 | 2015-07-02 | アストリム株式会社 | Immunotherapy using t precursor cells derived from pluripotent stem cells having rearranged t cell receptor genes |
| JP2017514471A (en) | 2014-04-23 | 2017-06-08 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | Chimeric antigen receptor (CAR) and method for producing and using the same |
| JP6661544B2 (en) * | 2014-04-24 | 2020-03-11 | ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | Automatic generation of genetically modified T cells |
| EP3191596B1 (en) | 2014-09-11 | 2019-10-09 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Lentiviral vector for treating hemoglobin disorders |
| FR3026744B1 (en) * | 2014-10-06 | 2024-04-19 | Assist Publique Hopitaux De Paris | METHOD FOR GENERATION OF T CELL PROGENITORS |
| JP2018518181A (en) | 2015-06-17 | 2018-07-12 | ザ ユーエービー リサーチ ファンデーション | CRISPR / Cas9 complex for introducing functional polypeptides into cells of the blood cell lineage |
| US20190142867A1 (en) | 2016-04-08 | 2019-05-16 | The Governing Council Of The University Of Toronto | Method for generating progenitor t cells from stem and/or progenitor cells and use of same |
| HUE060548T2 (en) * | 2017-02-13 | 2023-03-28 | Hopitaux Paris Assist Publique | Method for generating t cells progenitors |
-
2018
- 2018-02-12 HU HUE18704551A patent/HUE060548T2/en unknown
- 2018-02-12 PT PT187045513T patent/PT3580330T/en unknown
- 2018-02-12 CN CN201880024963.1A patent/CN110506110A/en active Pending
- 2018-02-12 BR BR112019016672A patent/BR112019016672A8/en unknown
- 2018-02-12 ES ES18704551T patent/ES2931530T3/en active Active
- 2018-02-12 PL PL18704551.3T patent/PL3580330T3/en unknown
- 2018-02-12 US US16/485,488 patent/US20200046767A1/en active Pending
- 2018-02-12 CA CA3053294A patent/CA3053294A1/en active Pending
- 2018-02-12 EP EP22158116.8A patent/EP4067482A1/en active Pending
- 2018-02-12 WO PCT/EP2018/053406 patent/WO2018146297A1/en active Application Filing
- 2018-02-12 JP JP2019565052A patent/JP7164798B2/en active Active
- 2018-02-12 EP EP18704551.3A patent/EP3580330B1/en active Active
- 2018-02-12 KR KR1020197024529A patent/KR20190117550A/en active IP Right Grant
- 2018-02-12 AU AU2018217404A patent/AU2018217404B2/en active Active
- 2018-02-12 MA MA047541A patent/MA47541A/en unknown
- 2018-02-12 DK DK18704551.3T patent/DK3580330T3/en active
-
2019
- 2019-08-12 IL IL26864119A patent/IL268641A/en unknown
-
2020
- 2020-09-02 US US17/010,208 patent/US11426430B2/en active Active
-
2021
- 2021-02-11 US US17/173,668 patent/US11642376B2/en active Active
- 2021-02-11 US US17/173,632 patent/US11638723B2/en active Active
-
2022
- 2022-09-28 JP JP2022154550A patent/JP2022185024A/en active Pending
-
2023
- 2023-04-06 US US18/296,623 patent/US20230293586A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7164798B2 (en) | 2022-11-02 |
| MA47541A (en) | 2019-12-18 |
| US20210169934A1 (en) | 2021-06-10 |
| CN110506110A (en) | 2019-11-26 |
| WO2018146297A1 (en) | 2018-08-16 |
| AU2018217404B2 (en) | 2024-03-28 |
| KR20190117550A (en) | 2019-10-16 |
| US11638723B2 (en) | 2023-05-02 |
| RU2019125600A (en) | 2021-03-15 |
| RU2019125600A3 (en) | 2021-11-03 |
| US11426430B2 (en) | 2022-08-30 |
| CA3053294A1 (en) | 2018-08-16 |
| DK3580330T3 (en) | 2022-12-05 |
| AU2018217404A2 (en) | 2019-09-19 |
| US11642376B2 (en) | 2023-05-09 |
| AU2018217404A1 (en) | 2019-09-05 |
| BR112019016672A2 (en) | 2020-04-14 |
| PL3580330T3 (en) | 2023-01-16 |
| US20210169935A1 (en) | 2021-06-10 |
| ES2931530T3 (en) | 2022-12-30 |
| US20230293586A1 (en) | 2023-09-21 |
| US20200046767A1 (en) | 2020-02-13 |
| JP2020513844A (en) | 2020-05-21 |
| IL268641A (en) | 2019-10-31 |
| EP3580330A1 (en) | 2019-12-18 |
| BR112019016672A8 (en) | 2022-11-08 |
| US20200390817A1 (en) | 2020-12-17 |
| JP2022185024A (en) | 2022-12-13 |
| EP4067482A1 (en) | 2022-10-05 |
| HUE060548T2 (en) | 2023-03-28 |
| EP3580330B1 (en) | 2022-08-31 |
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