PT3548613T - Glutaminil ciclases bacterianas e seus inibidores para utilização no tratamento de periodontite - Google Patents

Glutaminil ciclases bacterianas e seus inibidores para utilização no tratamento de periodontite

Info

Publication number
PT3548613T
PT3548613T PT178221669T PT17822166T PT3548613T PT 3548613 T PT3548613 T PT 3548613T PT 178221669 T PT178221669 T PT 178221669T PT 17822166 T PT17822166 T PT 17822166T PT 3548613 T PT3548613 T PT 3548613T
Authority
PT
Portugal
Prior art keywords
periodontitis
inhibitors
treatment
glutaminyl cyclases
bacterial glutaminyl
Prior art date
Application number
PT178221669T
Other languages
English (en)
Original Assignee
Fraunhofer Ges Forschung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Ges Forschung filed Critical Fraunhofer Ges Forschung
Publication of PT3548613T publication Critical patent/PT3548613T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/02—Aminoacyltransferases (2.3.2)
    • C12Y203/02005—Glutaminyl-peptide cyclotransferase (2.3.2.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT178221669T 2016-12-02 2017-12-01 Glutaminil ciclases bacterianas e seus inibidores para utilização no tratamento de periodontite PT3548613T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16201913 2016-12-02

Publications (1)

Publication Number Publication Date
PT3548613T true PT3548613T (pt) 2021-03-11

Family

ID=57539021

Family Applications (1)

Application Number Title Priority Date Filing Date
PT178221669T PT3548613T (pt) 2016-12-02 2017-12-01 Glutaminil ciclases bacterianas e seus inibidores para utilização no tratamento de periodontite

Country Status (8)

Country Link
US (1) US11186572B2 (pt)
EP (1) EP3548613B1 (pt)
JP (1) JP7177053B2 (pt)
CN (1) CN110139929A (pt)
CA (1) CA3045208A1 (pt)
ES (1) ES2862405T3 (pt)
PT (1) PT3548613T (pt)
WO (1) WO2018100159A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111757883B (zh) 2018-02-23 2024-02-13 弗劳恩霍夫应用研究促进协会 用于治疗牙周疾病和相关疾病的细菌谷氨酰胺酰环化酶的新抑制剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68923891T2 (de) * 1988-03-16 1996-02-22 Smithkline Beecham Farm Heterocyclische Derivate.
JPH08325234A (ja) * 1995-05-30 1996-12-10 Yamanouchi Pharmaceut Co Ltd 安息香酸誘導体又はその塩
EP1173438A1 (en) * 1999-04-16 2002-01-23 Novo Nordisk A/S Substituted imidazoles, their preparation and use
JP2011505373A (ja) 2007-11-30 2011-02-24 ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド 抗菌剤としての２環式ｐｐａｔ阻害剤
CN104105691A (zh) 2011-11-08 2014-10-15 艾尼纳制药公司 G蛋白偶联mas受体调节剂及对与其相关的病症的治疗
CN104684895B (zh) 2012-06-08 2017-09-15 高等教育联邦系统-匹兹堡大学 Fbxo3抑制剂
TWI599567B (zh) * 2013-03-14 2017-09-21 健生藥品公司 Ｐ２ｘ７調節劑

Also Published As

Publication number Publication date
US20190367511A1 (en) 2019-12-05
JP7177053B2 (ja) 2022-11-22
WO2018100159A1 (en) 2018-06-07
ES2862405T3 (es) 2021-10-07
EP3548613B1 (en) 2021-01-27
EP3548613A1 (en) 2019-10-09
CA3045208A1 (en) 2018-06-07
CN110139929A (zh) 2019-08-16
JP2019536799A (ja) 2019-12-19
US11186572B2 (en) 2021-11-30

Similar Documents

Publication Publication Date Title
IL265922A (en) tyk2 inhibitors and uses thereof
IL266109A (en) tyk2 inhibitors and uses thereof
EP3471727A4 (en) CXCR4 INHIBITORS AND USES THEREOF
EP3472129A4 (en) CXCR4 INHIBITORS AND USES THEREOF
EP3414311A4 (en) COMPOSITIONS AND METHODS FOR USE IN SURFACE DECONTAMINATION
EP3510040A4 (en) ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE
IL267291B (en) Actonucleotidase inhibitors and methods of using them
EP3471726A4 (en) CXCR4 INHIBITORS AND USES THEREOF
PT3532459T (pt) Inibidores de lsd1 e seus usos médicos
HUE063120T2 (hu) LRRC33-inhibitorok és alkalmazásuk
IL267238A (en) The paranase inhibitors and their use
IL264232A (en) Combination of ceftibuten and clavulanic acid for use in the treatment of bacterial infections
IL263804A (en) Wnt inhibitors for use in the treatment of fibrosis
PT3093022T (pt) Inibidores gata-3 para utilização no tratamento de asma desencadeada por th2
EP3433035A4 (en) COMPOSITIONS AND METHODS OF USE IN SAND CASTING.
GB201702160D0 (en) Inhibitors for use in therapy
PL3373922T3 (pl) Kompozycje i sposoby do stosowania do leczenia homocystynurii
PT3548613T (pt) Glutaminil ciclases bacterianas e seus inibidores para utilização no tratamento de periodontite
EP3463371A4 (en) KU INHIBITORS AND THEIR USE
PT3589632T (pt) Novos inibidores de glutaminil ciclases bacterianas para utilização no tratamento de doenças periodontais e relacionadas
IL267243A (en) The paranase inhibitors and their use
AU2018303280A1 (en) Clusterin for use in the treatment of thrombotic microangiopathies
IL253418A0 (en) Nisin-based compounds and their use in the treatment of bacterial infections
HK1244409A1 (zh) 改善衛生的方法和用於該方法中的製品和套件裝置
EP3503888A4 (en) INHIBITORS OF BCR ABL MUTANTS AND USE THEREOF