PT3138837T - Base livre de indacaterol na forma sólida - Google Patents
Base livre de indacaterol na forma sólidaInfo
- Publication number
- PT3138837T PT3138837T PT161899653T PT16189965T PT3138837T PT 3138837 T PT3138837 T PT 3138837T PT 161899653 T PT161899653 T PT 161899653T PT 16189965 T PT16189965 T PT 16189965T PT 3138837 T PT3138837 T PT 3138837T
- Authority
- PT
- Portugal
- Prior art keywords
- free base
- solid form
- indacaterol free
- indacaterol
- solid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2012/003961 WO2014044288A1 (en) | 2012-09-21 | 2012-09-21 | Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3138837T true PT3138837T (pt) | 2022-02-24 |
Family
ID=46982512
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT137592309T PT2897937T (pt) | 2012-09-21 | 2013-09-09 | Processo para a preparação de indacaterol e de intermediários do mesmo |
| PT161899653T PT3138837T (pt) | 2012-09-21 | 2013-09-09 | Base livre de indacaterol na forma sólida |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT137592309T PT2897937T (pt) | 2012-09-21 | 2013-09-09 | Processo para a preparação de indacaterol e de intermediários do mesmo |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9475772B2 (pt) |
| JP (2) | JP6371768B2 (pt) |
| CA (2) | CA3077888C (pt) |
| ES (3) | ES2663468T3 (pt) |
| HR (1) | HRP20221160T1 (pt) |
| PL (1) | PL3848354T3 (pt) |
| PT (2) | PT2897937T (pt) |
| WO (2) | WO2014044288A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014044288A1 (en) * | 2012-09-21 | 2014-03-27 | Crystal Pharma Sa | Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof |
| WO2014154841A1 (en) * | 2013-03-27 | 2014-10-02 | Laboratorios Lesvi, S.L. | Process for the manufacture of (r)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1h)-quinolin-2-one |
| CN104744360B (zh) * | 2013-12-26 | 2017-02-22 | 成都伊诺达博医药科技有限公司 | 一种合成茚达特罗的新方法 |
| EP3092217B1 (en) * | 2014-01-09 | 2020-06-03 | Davuluri, Ramamohan Rao | A novel process for preparation of indacaterol or its pharmaceutically acceptable salts |
| WO2017055506A1 (en) | 2015-09-29 | 2017-04-06 | Laboratorios Lesvi, S.L. | Mixed solvate of (r)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl] -8-hydroxy-1h-quinolin-2-one l-tartrate |
| CN108101841B (zh) * | 2016-11-24 | 2021-04-06 | 江苏恒瑞医药股份有限公司 | 一种制备茚达特罗或其盐的方法 |
| US10130265B1 (en) * | 2017-05-15 | 2018-11-20 | Herddogg, Inc. | Animal tag system |
| EP3735406B1 (en) | 2018-01-02 | 2022-05-11 | Deva Holding Anonim Sirketi | A process for preparation of 5-(2-(substituted-amino)-1-hydroxyethyl)-8-(substituted-oxy) quinolin-2(1h)-one |
| CN108409650A (zh) * | 2018-02-09 | 2018-08-17 | 南京法恩化学有限公司 | 一种马来酸茚达特罗的制备方法 |
| CN109721534B (zh) * | 2018-09-25 | 2022-05-20 | 四川海思科制药有限公司 | 一种马来酸茚达特罗中间体及其制备方法和用途 |
| CN111808021B (zh) * | 2019-04-10 | 2021-08-31 | 上海谷森医药有限公司 | 茚达特罗及其盐的制备方法 |
| CN110128339B (zh) * | 2019-05-31 | 2022-03-08 | 苏州芝宇生物科技有限公司 | 一种茚达特罗及其盐衍生物的合成方法和合成用中间体 |
| CN110724095B (zh) * | 2019-09-12 | 2023-06-09 | 上海方予健康医药科技有限公司 | 一种茚达特罗乙酸盐的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9913083D0 (en) * | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| GB0029562D0 (en) | 2000-12-04 | 2001-01-17 | Novartis Ag | Organic compounds |
| US6653323B2 (en) * | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| GB0217225D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicinal compounds |
| PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| TWI324150B (en) | 2003-02-28 | 2010-05-01 | Novartis Ag | Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt |
| GB0413960D0 (en) | 2004-06-22 | 2004-07-28 | Novartis Ag | Organic compounds |
| GB0511066D0 (en) * | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| GB0523656D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| TW200745084A (en) * | 2006-03-08 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| ES2296516B1 (es) * | 2006-04-27 | 2009-04-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
| JP2010519195A (ja) * | 2007-02-19 | 2010-06-03 | シプラ・リミテッド | 薬学的組成物 |
| WO2014044288A1 (en) * | 2012-09-21 | 2014-03-27 | Crystal Pharma Sa | Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof |
-
2012
- 2012-09-21 WO PCT/EP2012/003961 patent/WO2014044288A1/en active Application Filing
-
2013
- 2013-09-09 PT PT137592309T patent/PT2897937T/pt unknown
- 2013-09-09 WO PCT/EP2013/068618 patent/WO2014044566A1/en active Application Filing
- 2013-09-09 HR HRP20221160TT patent/HRP20221160T1/hr unknown
- 2013-09-09 JP JP2015532366A patent/JP6371768B2/ja active Active
- 2013-09-09 ES ES13759230.9T patent/ES2663468T3/es active Active
- 2013-09-09 PL PL21158883.5T patent/PL3848354T3/pl unknown
- 2013-09-09 ES ES21158883T patent/ES2929327T3/es active Active
- 2013-09-09 PT PT161899653T patent/PT3138837T/pt unknown
- 2013-09-09 US US14/427,568 patent/US9475772B2/en active Active
- 2013-09-09 CA CA3077888A patent/CA3077888C/en active Active
- 2013-09-09 CA CA2884197A patent/CA2884197C/en active Active
- 2013-09-09 ES ES16189965T patent/ES2908417T3/es active Active
-
2016
- 2016-09-28 US US15/278,945 patent/US10040765B2/en active Active
-
2018
- 2018-05-23 JP JP2018099089A patent/JP2018141010A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10040765B2 (en) | 2018-08-07 |
| ES2908417T3 (es) | 2022-04-29 |
| PT2897937T (pt) | 2018-03-12 |
| ES2929327T3 (es) | 2022-11-28 |
| CA3077888C (en) | 2022-08-02 |
| JP6371768B2 (ja) | 2018-08-08 |
| CA2884197A1 (en) | 2014-03-27 |
| CA3077888A1 (en) | 2014-03-27 |
| US20170015628A1 (en) | 2017-01-19 |
| JP2015529231A (ja) | 2015-10-05 |
| WO2014044288A1 (en) | 2014-03-27 |
| CA2884197C (en) | 2022-05-03 |
| HRP20221160T1 (hr) | 2022-11-25 |
| PL3848354T3 (pl) | 2022-12-19 |
| ES2663468T3 (es) | 2018-04-12 |
| WO2014044566A1 (en) | 2014-03-27 |
| US20150225346A1 (en) | 2015-08-13 |
| US9475772B2 (en) | 2016-10-25 |
| JP2018141010A (ja) | 2018-09-13 |
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