PT2593090T - C-met modulator pharmaceutical compositions - Google Patents

C-met modulator pharmaceutical compositions

Info

Publication number
PT2593090T
PT2593090T PT117407643T PT11740764T PT2593090T PT 2593090 T PT2593090 T PT 2593090T PT 117407643 T PT117407643 T PT 117407643T PT 11740764 T PT11740764 T PT 11740764T PT 2593090 T PT2593090 T PT 2593090T
Authority
PT
Portugal
Prior art keywords
pharmaceutical compositions
modulator pharmaceutical
met
met modulator
compositions
Prior art date
Application number
PT117407643T
Other languages
Portuguese (pt)
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45469828&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2593090(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of PT2593090T publication Critical patent/PT2593090T/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT117407643T 2010-07-16 2011-07-18 C-met modulator pharmaceutical compositions PT2593090T (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36525310P 2010-07-16 2010-07-16
US37084310P 2010-08-05 2010-08-05

Publications (1)

Publication Number Publication Date
PT2593090T true PT2593090T (en) 2021-11-04

Family

ID=45469828

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117407643T PT2593090T (en) 2010-07-16 2011-07-18 C-met modulator pharmaceutical compositions

Country Status (23)

Country Link
US (10) US9724342B2 (en)
EP (2) EP4014971A1 (en)
JP (3) JP5934204B2 (en)
KR (6) KR20200029633A (en)
CN (3) CN103221035A (en)
AR (1) AR082252A1 (en)
AU (4) AU2011278950C1 (en)
BR (1) BR112013000980B1 (en)
CA (1) CA2805645C (en)
DK (1) DK2593090T3 (en)
EA (1) EA030435B1 (en)
ES (1) ES2904646T3 (en)
HU (1) HUE057184T2 (en)
IL (2) IL224189A (en)
LT (1) LT2593090T (en)
MX (1) MX336741B (en)
NZ (1) NZ607118A (en)
PL (1) PL2593090T3 (en)
PT (1) PT2593090T (en)
SG (2) SG187060A1 (en)
TW (3) TW201602083A (en)
WO (1) WO2012009722A1 (en)
ZA (1) ZA201300458B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI447108B (en) 2009-01-16 2014-08-01 Exelixis Inc Malate salts of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof
UA108618C2 (en) 2009-08-07 2015-05-25 APPLICATION OF C-MET-MODULATORS IN COMBINATION WITH THEMOSOLOMID AND / OR RADIATION THERAPY FOR CANCER TREATMENT
PL2593090T3 (en) 2010-07-16 2022-02-21 Exelixis, Inc. C-met modulator pharmaceutical compositions
ES2754973T5 (en) 2010-09-27 2023-03-13 Exelixis Inc Dual MET and VEGF inhibitors for the treatment of castration-resistant prostate cancer and osteoblastic bone metastases
KR20210147117A (en) * 2011-02-10 2021-12-06 엑셀리시스, 인코포레이티드 Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds
US20120252840A1 (en) * 2011-04-04 2012-10-04 Exelixis, Inc. Method of Treating Cancer
GEP201706678B (en) 2011-05-02 2017-06-12 Exelixis Inc Method of treating cancer and bone cancer
EP2758057B1 (en) 2011-09-22 2017-05-31 Exelixis, Inc. Method for treating osteoporosis
BR112014009302B1 (en) 2011-10-20 2020-04-28 Exelis Inc Us/Us process for preparing quinoline derivatives
US9861624B2 (en) 2012-05-02 2018-01-09 Exelixis, Inc. Method of treating cancer
CN103664776B (en) * 2012-09-26 2016-05-04 正大天晴药业集团股份有限公司 The preparation method of a kind of tyrosine kinase inhibitor and intermediate thereof
UA119321C2 (en) 2013-03-15 2019-06-10 Екселіксіс, Інк. Metabolites of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide
ES2927651T3 (en) 2013-04-04 2022-11-10 Exelixis Inc Cabozantinib dosage form and use in cancer treatment
CN104370811B (en) * 2013-08-15 2019-02-12 广东东阳光药业有限公司 A kind of novel crystal forms of quinoline compound and preparation method thereof
CN104649969B (en) * 2013-11-22 2019-02-12 广东东阳光药业有限公司 A kind of salt and preparation method thereof for Buddhist nun's class drug
CN103751140A (en) * 2014-01-15 2014-04-30 青岛市肿瘤医院 Cabozantinib dispersible tablets and preparation method thereof
CA3181899A1 (en) 2014-02-14 2015-08-20 Exelixis, Inc. Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use
JP6666849B2 (en) * 2014-03-17 2020-03-18 エグゼリクシス， インコーポレイテッド Administration of cabozantinib preparation
CN104788372B (en) * 2014-07-25 2018-01-30 上海圣考医药科技有限公司 A kind of deuterated card is rich to replace Buddhist nun's derivative, its preparation method, application and its intermediate
WO2016019285A1 (en) 2014-07-31 2016-02-04 Exelixis, Inc. Method of preparing fluorine-18 labeled cabozantinib and its analogs
CA2957466C (en) 2014-08-05 2023-10-17 Exelixis, Inc. Drug combinations to treat multiple myeloma
CN105503717A (en) * 2014-09-24 2016-04-20 江苏奥赛康药业股份有限公司 Cabozantinib malate compound and medicine composition therewith
CA3020749A1 (en) * 2016-04-15 2017-10-19 Exelixis, Inc. Method of treating renal cell carcinoma using n-(4-(6,7-dimethoxyquinolin-4-yloxy) phenyl)-n'-(4-fluoropheny)cyclopropane-1,1-dicarboxamide, (2s)-hydroxybutanedioate
US20210030737A1 (en) * 2016-04-19 2021-02-04 Exelixis, Inc. Triple Negative Breast Cancer Treatment Method
CA3038500A1 (en) 2016-09-27 2018-04-05 Andrea B. Apolo Method of treating urothelial carcinoma and other genitourinary malignancies using n-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
US11261160B2 (en) * 2016-12-07 2022-03-01 Msn Laboratories Private Limited, R&D Center Process for the preparation of N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1, 1-dicarboxamide, (2S)-hydroxybutanedioate and its polymorphs thereof
AU2018210397B2 (en) 2017-01-20 2024-02-29 Exelixis, Inc. Combinations of cabozantinib and atezolizumab to treat cancer
CA3060370A1 (en) 2017-05-26 2018-11-29 Exelixis, Inc. Crystalline solid forms of salts of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorphenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use
JP7045726B2 (en) * 2017-06-16 2022-04-01 ベータ ファーマ，インコーポレイテッド N- (2- (2- (dimethylamino) ethoxy) -4-methoxy-5-((4- (1-methyl-1H-indole-3-yl) pyrimidin-2-yl) amino) phenyl) acrylamide and Pharmaceutical formulation of the salt
US20190262330A1 (en) * 2017-12-21 2019-08-29 Exelixis, Inc. Method of Treating Hepatocellular Carcinoma Using N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, (2S)-hydroxybutanedioate
IL300824A (en) 2018-01-26 2023-04-01 Exelixis Inc Compounds for the treatment of kinase-dependent disorders
CN113292537B (en) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 Salts of kinase inhibitors and compositions thereof
WO2020075196A1 (en) * 2018-10-11 2020-04-16 Cipla Limited Polymorphs of n-(4-(6,7-dimethoxyquinolin-4-yloxy) phenyl)-n'-(4-fluorophenyl)cyclopropane-1, 1-dicarboxamide, (s)- malate, methods of production and pharmaceutical uses thereof
CN115135326B (en) * 2020-03-16 2024-09-13 正大天晴药业集团股份有限公司 Combination pharmaceutical composition of compounds as c-Met kinase inhibitors and use thereof
US20230192619A1 (en) * 2020-04-30 2023-06-22 Exelixis, Inc. Processes for the Preparation of a Kinase Inhibitor
PE20240223A1 (en) * 2020-11-05 2024-02-16 Exelixis Inc PHARMACEUTICAL COMPOSITIONS OF A KINASE INHIBITOR
US11613630B2 (en) * 2020-12-03 2023-03-28 Iowa State University Research Foundation Solid dry-type lubricant
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003225668A1 (en) 2002-03-01 2003-09-16 Pintex Pharmaceutical, Inc. Pin1-modulating compounds and methods of use thereof
EP2612853A1 (en) 2003-09-26 2013-07-10 Exelixis Inc. c-Met modulators and methods of use
KR101167573B1 (en) 2003-11-07 2012-07-30 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties
RS54033B1 (en) * 2003-12-25 2015-10-30 Eisai R&D Management Co. Ltd. Crystal of salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)amino-phenoxy)-7-methoxy-6-quinolinecarboxamide or of solvate thereof and processes for producing these
WO2006014325A2 (en) 2004-07-02 2006-02-09 Exelixis, Inc. C-met modulators and method of use
AU2006231646A1 (en) 2005-04-06 2006-10-12 Exelixis, Inc. C-Met modulators and methods of use
WO2008076415A1 (en) 2006-12-14 2008-06-26 Exelixis, Inc. Methods of using mek inhibitors
US20080200515A1 (en) 2006-12-29 2008-08-21 Tap Pharmaceutical Products Inc. Solid state forms of enantiopure ilaprazole
UY31800A (en) 2008-05-05 2009-11-10 Smithkline Beckman Corp CANCER TREATMENT METHOD USING A CMET AND AXL INHIBITOR AND AN ERBB INHIBITOR
TW201035017A (en) 2008-09-26 2010-10-01 Smithkline Beecham Corp Preparation of a quinolinyloxydiphenylcyclopropanedicarboxamide
EA019247B1 (en) 2008-11-13 2014-02-28 Экселиксис, Инк. Methods of preparing quinoline derivatives
JP2012511017A (en) 2008-12-04 2012-05-17 エグゼリクシス， インコーポレイテッド Method for preparing quinoline derivatives
TWI447108B (en) 2009-01-16 2014-08-01 Exelixis Inc Malate salts of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof
EP2454238A1 (en) 2009-07-17 2012-05-23 Exelixis, Inc. Crystalline forms of n-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]-quinolin-4-yl}oxy)phenyl]-n'-(4-fluorophenyl)cyclopropane-1, 1-dicarboxamide
UA108618C2 (en) 2009-08-07 2015-05-25 APPLICATION OF C-MET-MODULATORS IN COMBINATION WITH THEMOSOLOMID AND / OR RADIATION THERAPY FOR CANCER TREATMENT
EP2475390A4 (en) * 2009-09-09 2014-01-01 Quintiles Transnat Corp Methods and compositions for the treatment of receptor tyrosine kinase mediated diseases or disorders
WO2011112896A1 (en) 2010-03-12 2011-09-15 Exelixis, Inc Hydrated crystalline forms of n-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]-quinolin-4-yl}oxy)phenyl]-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
US20120070368A1 (en) 2010-04-16 2012-03-22 Exelixis, Inc. Methods of Using C-Met Modulators
PL2593090T3 (en) 2010-07-16 2022-02-21 Exelixis, Inc. C-met modulator pharmaceutical compositions
EP2593091A1 (en) 2010-07-16 2013-05-22 Exelixis, Inc. C-met modulator pharmaceutical compositions
WO2012044577A1 (en) 2010-09-27 2012-04-05 Exelixis, Inc. Dual inhibitors of met and vegf for the treatment of castration resistant prostate cancer and osteoblastic bone metastases
ES2754973T5 (en) 2010-09-27 2023-03-13 Exelixis Inc Dual MET and VEGF inhibitors for the treatment of castration-resistant prostate cancer and osteoblastic bone metastases
JP2013540759A (en) 2010-09-27 2013-11-07 エクセリクシス， インク． Dual inhibitors of MET and VEGF for the treatment of castration resistant prostate cancer and osteoblastic metastases
CN103327979A (en) 2010-11-22 2013-09-25 葛兰素史密斯克莱知识产权（第2号）有限公司 Method of treating cancer
KR20210147117A (en) 2011-02-10 2021-12-06 엑셀리시스, 인코포레이티드 Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds
US20120252840A1 (en) 2011-04-04 2012-10-04 Exelixis, Inc. Method of Treating Cancer
GEP201706678B (en) 2011-05-02 2017-06-12 Exelixis Inc Method of treating cancer and bone cancer
TW201306842A (en) 2011-06-15 2013-02-16 Exelixis Inc Combination therapies for treating hematologic malignancies using pyridopyrimidinone inhibitors of PI3K/MTOR with bendamustine and/or rituximab
BR112014009302B1 (en) 2011-10-20 2020-04-28 Exelis Inc Us/Us process for preparing quinoline derivatives
CA3020749A1 (en) * 2016-04-15 2017-10-19 Exelixis, Inc. Method of treating renal cell carcinoma using n-(4-(6,7-dimethoxyquinolin-4-yloxy) phenyl)-n'-(4-fluoropheny)cyclopropane-1,1-dicarboxamide, (2s)-hydroxybutanedioate

Also Published As

Publication number Publication date
KR20130137586A (en) 2013-12-17
AU2020203645A1 (en) 2020-06-25
AU2011278950C1 (en) 2018-11-22
EP4014971A1 (en) 2022-06-22
US10039757B2 (en) 2018-08-07
JP5934204B2 (en) 2016-06-15
EP2593090A1 (en) 2013-05-22
PL2593090T3 (en) 2022-02-21
KR20210014770A (en) 2021-02-09
TWI619495B (en) 2018-04-01
US20240156804A1 (en) 2024-05-16
KR101862324B1 (en) 2018-05-29
MX2013000567A (en) 2013-05-01
KR20220005631A (en) 2022-01-13
WO2012009722A1 (en) 2012-01-19
TW201219371A (en) 2012-05-16
DK2593090T3 (en) 2021-10-25
AU2011278950A1 (en) 2013-03-07
SG187060A1 (en) 2013-02-28
IL224189A (en) 2017-07-31
JP2019142879A (en) 2019-08-29
US11123338B2 (en) 2021-09-21
US20130337015A1 (en) 2013-12-19
US20180311229A1 (en) 2018-11-01
US20220370436A1 (en) 2022-11-24
JP2016188215A (en) 2016-11-04
US20210379050A1 (en) 2021-12-09
LT2593090T (en) 2022-01-10
KR20180056807A (en) 2018-05-29
CN103221035A (en) 2013-07-24
US9724342B2 (en) 2017-08-08
CN106420743A (en) 2017-02-22
US20220031688A1 (en) 2022-02-03
TW201735925A (en) 2017-10-16
AU2011278950B2 (en) 2016-07-21
AR082252A1 (en) 2012-11-21
US20170266178A1 (en) 2017-09-21
TWI516477B (en) 2016-01-11
CA2805645C (en) 2019-05-07
KR20190042768A (en) 2019-04-24
CN114209699A (en) 2022-03-22
US20200121671A1 (en) 2020-04-23
BR112013000980B1 (en) 2022-08-16
US20170143689A1 (en) 2017-05-25
ES2904646T3 (en) 2022-04-05
JP6503317B2 (en) 2019-04-17
NZ607118A (en) 2015-05-29
MX336741B (en) 2016-01-29
AU2018220045B2 (en) 2020-03-05
EA201300146A1 (en) 2013-06-28
EP2593090B1 (en) 2021-10-13
IL253333A0 (en) 2017-09-28
US10034873B2 (en) 2018-07-31
HUE057184T2 (en) 2022-04-28
AU2018220045A1 (en) 2018-09-06
ZA201300458B (en) 2013-09-25
SG10201609324UA (en) 2017-01-27
TW201602083A (en) 2016-01-16
AU2016247044A1 (en) 2016-11-03
KR20200029633A (en) 2020-03-18
BR112013000980A2 (en) 2018-03-13
JP2013531045A (en) 2013-08-01
CA2805645A1 (en) 2012-01-19
EA030435B1 (en) 2018-08-31
US10548888B2 (en) 2020-02-04
US20220087999A1 (en) 2022-03-24

Similar Documents

Publication Publication Date Title
IL253333A0 (en) C-met modulator pharmaceutical compositions
HK1246170A1 (en) Pharmaceutical composition
IL223535A (en) Solid pharmaceutical compositions
ZA201301766B (en) Pharmaceutical compositions
ZA201300718B (en) Pharmaceutical compositions
ZA201207670B (en) Pharmaceutical compositions
GB201010453D0 (en) Pharmaceutical composition
ZA201303223B (en) Pharmaceutical compositions
ZA201303177B (en) Pharmaceutical compositions
IL226554A (en) Pharmaceutical compositions comprising alisporivir
GB201001911D0 (en) Pharmaceutical composition
EP2560678A4 (en) Pharmaceutical compositions
ZA201303732B (en) Pharmaceutical compositions
GB201008590D0 (en) Pharmaceutical compositions
GB201005403D0 (en) Novel pharmaceutical compositions
GB201019775D0 (en) Pharmaceutical composition