PT2516471T - Polipéptidos quiméricos e a sua utilização na descolonização bacteriana - Google Patents
Polipéptidos quiméricos e a sua utilização na descolonização bacterianaInfo
- Publication number
- PT2516471T PT2516471T PT107982746T PT10798274T PT2516471T PT 2516471 T PT2516471 T PT 2516471T PT 107982746 T PT107982746 T PT 107982746T PT 10798274 T PT10798274 T PT 10798274T PT 2516471 T PT2516471 T PT 2516471T
- Authority
- PT
- Portugal
- Prior art keywords
- chimeric polypeptides
- decolonization
- bacterial
- bacterial decolonization
- chimeric
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24075—Lysostaphin (3.4.24.75)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09015998A EP2338916A1 (en) | 2009-12-23 | 2009-12-23 | Chimeric polypeptides and their use in bacterial decoloniation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2516471T true PT2516471T (pt) | 2016-10-20 |
Family
ID=42153758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT107982746T PT2516471T (pt) | 2009-12-23 | 2010-12-23 | Polipéptidos quiméricos e a sua utilização na descolonização bacteriana |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9057059B2 (pt) |
| EP (2) | EP2338916A1 (pt) |
| CY (1) | CY1118331T1 (pt) |
| DK (1) | DK2516471T4 (pt) |
| ES (1) | ES2597579T5 (pt) |
| HR (1) | HRP20161320T4 (pt) |
| HU (1) | HUE031164T2 (pt) |
| LT (1) | LT2516471T (pt) |
| PL (1) | PL2516471T5 (pt) |
| PT (1) | PT2516471T (pt) |
| RS (1) | RS55230B1 (pt) |
| SI (1) | SI2516471T2 (pt) |
| SM (1) | SMT201600365B (pt) |
| WO (1) | WO2011076432A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9200251B1 (en) | 2011-03-31 | 2015-12-01 | David Gordon Bermudes | Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith |
| CA2872911C (en) | 2012-05-09 | 2023-10-03 | Contrafect Corporation | Biofilm prevention, disruption and treatment with bacteriophage lysin |
| US20150284452A1 (en) * | 2012-11-13 | 2015-10-08 | Iogenetics, Llc | Antimicrobial compositions |
| CN103122347B (zh) * | 2013-02-01 | 2015-04-22 | 中国科学院武汉病毒研究所 | 一种杀灭葡萄球菌的裂解酶及其应用 |
| SG11201600180WA (en) | 2013-07-11 | 2016-02-26 | Micreos Human Health Bv | Combination treatment for atopic dermatitis |
| EP2904912A1 (en) | 2014-02-07 | 2015-08-12 | Hyglos Invest GmbH | Novel high pressure method with endolysin for processing of foods |
| SG11201707345VA (en) | 2015-03-12 | 2017-10-30 | Micreos Human Health Bv | Combination of bactericidal agent with a lysosomotropic alkalinising agent for the treatment of a bacterial infection |
| CN104805066B (zh) * | 2015-05-18 | 2018-04-24 | 武汉菲吉乐科生物科技有限公司 | 一种葡萄球菌裂解酶及其应用 |
| KR102606309B1 (ko) | 2016-11-18 | 2023-11-24 | 뤼산도 아게 | 스태필로코커스 아우레우스에 대한 신규한 항미생물제 |
| US10256592B1 (en) * | 2017-04-27 | 2019-04-09 | Lockheed Martin Corporation | Device, system and method with cascaded burst mode laser amplified pumping oscillator signal |
| US20220024992A1 (en) * | 2018-11-02 | 2022-01-27 | The Rockefeller University | Compositions and methods comprising lysocins as bioengineered antimicrobials for use in targeting gram-negative bacteria |
| CA3136346A1 (en) * | 2019-05-08 | 2020-11-12 | Phagomed Biopharma Gmbh | Novel gardnerella endolysins and uses thereof |
| GB201906653D0 (en) * | 2019-05-10 | 2019-06-26 | Cc Biotech Ltd | Polypeptides for treatment of bacterial infections |
| EP3771463A1 (en) | 2019-07-29 | 2021-02-03 | Ludwig-Maximilians-Universität München | Stabilizing therapeutic proteins with piperazin- or morpholine-containing zwitterionic buffering substances |
| US20230140823A1 (en) | 2020-03-19 | 2023-05-04 | Micreos Human Health B.V. | A stabilized protein of interest. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2255561B (en) | 1991-04-20 | 1995-06-21 | Agricultural & Food Res | Lysins from bacteriophages |
| US5997862A (en) | 1997-10-31 | 1999-12-07 | New Horizons Diagnostics Corporation | Therapeutic treatment of group A streptococcal infections |
| US7572602B1 (en) * | 2004-12-03 | 2009-08-11 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleic acid encoding endolysin fusion protein |
| DK2037946T3 (en) | 2006-05-05 | 2015-04-27 | Gangagen Inc | ANTIMICROBIAL ACTIVITIES DERIVED BY PHAGER |
| IE20060488A1 (en) | 2006-06-29 | 2008-01-09 | Teagasc Agric Food Dev Authori | Recombinant staphylococcal phage lysin as an antibacterial agent |
| US20090130082A1 (en) * | 2007-10-18 | 2009-05-21 | Kaplan Jeffrey B | Compositions and methods for the treatment and prevention of infections caused by staphylococcus aureus bacteria |
| AU2009273845B2 (en) * | 2008-07-24 | 2016-02-04 | The United State Of America, As Represented By The Secretary Of Agriculture | Triple acting antimicrobials that are refractory to resistance development |
| US8383102B2 (en) * | 2009-05-21 | 2013-02-26 | The United States Of America As Represented By The Secretary Of Agriculture | Fusion of peptidoglycan hydrolase enzymes to a protein transduction domain allows eradication of both extracellular and intracellular gram positive pathogens |
-
2009
- 2009-12-23 EP EP09015998A patent/EP2338916A1/en not_active Ceased
-
2010
- 2010-12-23 US US13/519,095 patent/US9057059B2/en active Active
- 2010-12-23 LT LTEP10798274.6T patent/LT2516471T/lt unknown
- 2010-12-23 PT PT107982746T patent/PT2516471T/pt unknown
- 2010-12-23 SI SI201031300T patent/SI2516471T2/sl unknown
- 2010-12-23 WO PCT/EP2010/007941 patent/WO2011076432A1/en active Application Filing
- 2010-12-23 DK DK10798274.6T patent/DK2516471T4/da active
- 2010-12-23 EP EP10798274.6A patent/EP2516471B9/en active Active
- 2010-12-23 ES ES10798274T patent/ES2597579T5/es active Active
- 2010-12-23 RS RS20160853A patent/RS55230B1/sr unknown
- 2010-12-23 PL PL10798274T patent/PL2516471T5/pl unknown
- 2010-12-23 HU HUE10798274A patent/HUE031164T2/en unknown
-
2015
- 2015-05-11 US US14/709,118 patent/US10022430B2/en active Active
-
2016
- 2016-10-11 HR HRP20161320TT patent/HRP20161320T4/hr unknown
- 2016-10-12 CY CY20161101015T patent/CY1118331T1/el unknown
- 2016-10-12 SM SM201600365T patent/SMT201600365B/it unknown
-
2018
- 2018-06-15 US US16/009,321 patent/US10342857B2/en active Active
-
2019
- 2019-06-27 US US16/454,196 patent/US11116824B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2597579T5 (es) | 2021-03-18 |
| EP2516471B1 (en) | 2016-07-13 |
| PL2516471T5 (pl) | 2020-10-19 |
| PL2516471T3 (pl) | 2017-01-31 |
| SI2516471T1 (sl) | 2016-11-30 |
| US20190381151A1 (en) | 2019-12-19 |
| US20180333471A1 (en) | 2018-11-22 |
| EP2516471A1 (en) | 2012-10-31 |
| US11116824B2 (en) | 2021-09-14 |
| US20130004476A1 (en) | 2013-01-03 |
| US10022430B2 (en) | 2018-07-17 |
| HUE031164T2 (en) | 2017-06-28 |
| EP2516471B9 (en) | 2020-10-28 |
| RS55230B1 (sr) | 2017-02-28 |
| SI2516471T2 (sl) | 2020-07-31 |
| CY1118331T1 (el) | 2017-06-28 |
| US9057059B2 (en) | 2015-06-16 |
| DK2516471T4 (da) | 2020-08-03 |
| EP2516471B2 (en) | 2020-05-27 |
| ES2597579T3 (es) | 2017-01-19 |
| HRP20161320T4 (hr) | 2020-07-10 |
| DK2516471T3 (en) | 2016-10-17 |
| US20150238577A1 (en) | 2015-08-27 |
| US10342857B2 (en) | 2019-07-09 |
| HRP20161320T1 (hr) | 2016-12-16 |
| SMT201600365B (it) | 2016-11-10 |
| LT2516471T (lt) | 2016-10-25 |
| EP2338916A1 (en) | 2011-06-29 |
| WO2011076432A1 (en) | 2011-06-30 |
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