PT2413933T - 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide for the treatment of migraine via the oral or intravenous route - Google Patents

2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide for the treatment of migraine via the oral or intravenous route

Info

Publication number
PT2413933T
PT2413933T PT107594913T PT10759491T PT2413933T PT 2413933 T PT2413933 T PT 2413933T PT 107594913 T PT107594913 T PT 107594913T PT 10759491 T PT10759491 T PT 10759491T PT 2413933 T PT2413933 T PT 2413933T
Authority
PT
Portugal
Prior art keywords
benzamide
piperidin
trifluoro
pyridin
carbonyl
Prior art date
Application number
PT107594913T
Other languages
Portuguese (pt)
Inventor
Pilgrim Alison
F White James
M J Rupniak Nadia
Original Assignee
Colucid Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42826711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2413933(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Colucid Pharmaceuticals Inc filed Critical Colucid Pharmaceuticals Inc
Publication of PT2413933T publication Critical patent/PT2413933T/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/10—Energy storage using batteries

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT107594913T 2009-04-02 2010-04-02 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide for the treatment of migraine via the oral or intravenous route PT2413933T (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16609709P 2009-04-02 2009-04-02

Publications (1)

Publication Number Publication Date
PT2413933T true PT2413933T (en) 2017-12-12

Family

ID=42826711

Family Applications (1)

Application Number Title Priority Date Filing Date
PT107594913T PT2413933T (en) 2009-04-02 2010-04-02 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide for the treatment of migraine via the oral or intravenous route

Country Status (25)

Country Link
US (2) US20100256187A1 (en)
EP (1) EP2413933B2 (en)
JP (8) JP5727457B2 (en)
KR (1) KR101697801B1 (en)
CN (2) CN102753171A (en)
AU (1) AU2010232497B2 (en)
CA (1) CA2757019C (en)
CY (1) CY1119785T1 (en)
DK (1) DK2413933T4 (en)
ES (1) ES2655881T5 (en)
FI (1) FIC20230001I1 (en)
FR (1) FR23C1002I2 (en)
HK (1) HK1243923A1 (en)
HR (1) HRP20171742T4 (en)
HU (2) HUE037261T2 (en)
IL (1) IL215483A (en)
LT (2) LT2413933T (en)
MX (1) MX2011010359A (en)
NL (1) NL301214I2 (en)
NO (2) NO2413933T3 (en)
NZ (1) NZ596161A (en)
PL (1) PL2413933T5 (en)
PT (1) PT2413933T (en)
SI (1) SI2413933T2 (en)
WO (1) WO2010115125A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI263497B (en) 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
CA2720250C (en) 2008-04-04 2018-01-23 Forsight Labs, Llc Therapeutic device for pain management and vision
DK2413933T4 (en) 2009-04-02 2021-08-23 Colucid Pharmaceuticals Inc 2,4,6-Trifluoro-N- [6- (1-methyl-piperidine-4-carbonyl) -pyridin-2-yl] -benzamide for the treatment of migraine by oral or intravenous administration
US8697876B2 (en) 2010-04-02 2014-04-15 Colucid Pharmaceuticals, Inc. Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists
US12044905B2 (en) 2011-04-28 2024-07-23 Journey1 Inc Contact lenses for refractive correction
EP3014345A2 (en) 2013-06-26 2016-05-04 Nexisvision, Inc. Contact lenses for refractive correction
JP2020500936A (en) 2016-12-06 2020-01-16 コルシド ファーマシューティカルズ，インコーポレイテッド Compositions and methods relating to pyridinoylpiperidine 5-HT1F agonists
TWI826514B (en) 2018-09-04 2023-12-21 美商美國禮來大藥廠 Chronic nightly dosing of lasmiditan for migraine prevention
TWI776175B (en) 2019-07-09 2022-09-01 美商美國禮來大藥廠 Processes and intermediate for the large-scale preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate, and preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide acetate

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5011472A (en) * 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
US5698571A (en) * 1994-10-05 1997-12-16 Eli Lilly And Company 5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
NZ305166A (en) * 1995-03-20 1998-12-23 Lilly Co Eli 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles; preparation and medicaments
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
US6528529B1 (en) * 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US6777428B1 (en) * 1999-02-10 2004-08-17 Eli Lilly And Company 5-HT1f agonist
WO2002006196A1 (en) * 2000-07-13 2002-01-24 Merck Patent Gmbh Chiral compounds i
US6650463B2 (en) * 2001-03-13 2003-11-18 Seiko Epson Corporation Electrophoretic display device
WO2003000245A1 (en) * 2001-06-22 2003-01-03 Poseidon Pharmaceuticals A/S Compounds for use in disorders associated with mast cell or basophil activity
TWI263497B (en) † 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
EP1581498A2 (en) * 2002-11-22 2005-10-05 Bristol-Myers Squibb Company Pyridinyl, pyrimidinyl and pyrazinyl amides as potassium channel openers
GB0308186D0 (en) * 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
BRPI0409211A (en) * 2003-04-18 2006-03-28 Lilly Co Eli compound, pharmaceutical composition, methods for activating 5-ht1f receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal, and, use of a compound
EP1651595A2 (en) * 2003-05-30 2006-05-03 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
UA82711C2 (en) * 2003-09-12 2008-05-12 Эли Лилли Энд Компани Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
GB0510143D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds A1
KR20060067738A (en) * 2004-12-15 2006-06-20 주식회사 대웅제약 Novel arylamide derivatives as vanilloid receptor antagonist showing excellent analgesic activity and pharmaceutical compositions containing the same
US20060178349A1 (en) * 2005-01-24 2006-08-10 Pozen Inc. Compositions and therapeutic methods utilizing a combination of a 5-HT1F inhibitor and an NSAID
KR100976063B1 (en) * 2007-03-16 2010-08-17 동아제약주식회사 Novel benzamide derivatives and process for the preparation thereof
DK2413933T4 (en) † 2009-04-02 2021-08-23 Colucid Pharmaceuticals Inc 2,4,6-Trifluoro-N- [6- (1-methyl-piperidine-4-carbonyl) -pyridin-2-yl] -benzamide for the treatment of migraine by oral or intravenous administration
US8697876B2 (en) * 2010-04-02 2014-04-15 Colucid Pharmaceuticals, Inc. Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists

Also Published As

Publication number Publication date
JP7335397B2 (en) 2023-08-29
JP2016188241A (en) 2016-11-04
CA2757019C (en) 2018-05-15
FR23C1002I2 (en) 2023-11-24
IL215483A (en) 2017-07-31
HRP20171742T4 (en) 2021-08-06
HK1243923A1 (en) 2018-07-27
NL301214I1 (en) 2023-01-25
CN102753171A (en) 2012-10-24
HUS2300004I1 (en) 2023-02-28
HUE037261T2 (en) 2018-08-28
LTPA2023502I1 (en) 2023-01-25
JP2022163049A (en) 2022-10-25
EP2413933A2 (en) 2012-02-08
JP6887462B2 (en) 2021-06-16
AU2010232497A1 (en) 2011-11-24
AU2010232497B2 (en) 2016-05-19
LT2413933T (en) 2018-02-26
ES2655881T3 (en) 2018-02-22
JP2012522805A (en) 2012-09-27
JP2019189617A (en) 2019-10-31
JP7110446B2 (en) 2022-08-01
WO2010115125A3 (en) 2011-02-17
EP2413933B1 (en) 2017-11-01
FR23C1002I1 (en) 2023-03-10
DK2413933T4 (en) 2021-08-23
JP2015013903A (en) 2015-01-22
NO2413933T3 (en) 2018-03-31
EP2413933A4 (en) 2012-09-19
US20210401822A1 (en) 2021-12-30
SI2413933T2 (en) 2021-09-30
CA2757019A1 (en) 2010-10-07
KR20110136893A (en) 2011-12-21
WO2010115125A2 (en) 2010-10-07
CN107412230A (en) 2017-12-01
PL2413933T3 (en) 2018-04-30
MX2011010359A (en) 2012-02-23
NZ596161A (en) 2013-11-29
FIC20230001I1 (en) 2023-01-10
PL2413933T5 (en) 2021-10-18
HRP20171742T1 (en) 2018-02-09
JP2023175694A (en) 2023-12-12
SI2413933T1 (en) 2018-04-30
JP2018087247A (en) 2018-06-07
US20100256187A1 (en) 2010-10-07
EP2413933B2 (en) 2021-06-09
IL215483A0 (en) 2011-12-29
NL301214I2 (en) 2023-04-19
DK2413933T3 (en) 2018-01-29
JP5727457B2 (en) 2015-06-03
JP2021152008A (en) 2021-09-30
KR101697801B1 (en) 2017-01-18
NO2023002I1 (en) 2023-01-05
ES2655881T5 (en) 2021-11-25
CY1119785T1 (en) 2018-06-27

Similar Documents

Publication Publication Date Title
HUS2300004I1 (en) 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide for the treatment of migraine via the oral or intravenous route
IL241791A0 (en) Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
IL217768A (en) Laquinimod for the treatment of crohn&#39;s disease
SI2430022T1 (en) 1,2,4-TriazoloŠ4,3-aĆpyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
HK1150555A1 (en) Use of 2,4-pyrimidinediamines for the treatment of atherosclerosis 24-
IL216967B (en) 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives and use thereof for the treatment of diseases
SI2229369T1 (en) 6,7-dialkoxy-quinazoline derivatives useful for treatment of cancer-related disorders
ZA201001264B (en) 1-amino-alkylcycohxane derivatives for the treatment of cochleat tinnitus
IL218971A0 (en) Sulfoxide derivatives for the treatment of tumours
SI2240456T1 (en) Method for the production of 3, 6-dihydro-l, 3, 5-triazine derivatives from metformin and paraldehyde derivatives
IL209417A0 (en) 1-amino-alkylcyclohexane derivatives for the treatment of sleep disorders
EP2387565A4 (en) 2,4-pyrimidinediamine compounds for treatment of inflammatory disorders
PL2391366T3 (en) Substituted benzimidazoles for the treatment of astrocytomas
IL201447A0 (en) Use of 4 - cyclopropylmethoxy - n - (3, 5 - dichloro - 1 - oxidopyridin - 4 - yl) - 5 - (methoxy) pyridine - 2 - carboxamide for the treatment of cranial traumas
PL390435A1 (en) New derivatives of 1,3,5-triazine and process for the preparation thereof