PT2380874T - Pleuromutilin derivatives for the treatment of diseases mediated by microbes - Google Patents

Pleuromutilin derivatives for the treatment of diseases mediated by microbes

Info

Publication number
PT2380874T
PT2380874T PT110058633T PT11005863T PT2380874T PT 2380874 T PT2380874 T PT 2380874T PT 110058633 T PT110058633 T PT 110058633T PT 11005863 T PT11005863 T PT 11005863T PT 2380874 T PT2380874 T PT 2380874T
Authority
PT
Portugal
Prior art keywords
alkyl
microbes
treatment
cycloalkyl
diseases mediated
Prior art date
Application number
PT110058633T
Other languages
Portuguese (pt)
Inventor
Riedl Rosemarie
Heilmayer Werner
Badegruber Rudolf
Strickmann Dirk
Novak Rodger
Ferencic Matthias
Rama Chandra Murty Bulusu Atchyuta
Original Assignee
Nabriva Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38668870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2380874(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nabriva Therapeutics Ag filed Critical Nabriva Therapeutics Ag
Publication of PT2380874T publication Critical patent/PT2380874T/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/95—Spiro compounds containing "not free" spiro atoms
    • C07C2603/98—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members
    • C07C2603/99—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members containing eight-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R 3 are in vicinal position (if m = 0 then R 3 is in position 2', and if m = 1 then R 3 is on position 1'); R is ethyl or vinyl; R 1 is hydrogen or (C 1-6 )alkyl, R 2 is hydrogen or - (C 3 - 6 )cycloalkyl, or - unsubstituted (C 1 - 6 )alkyl, or - (C 1 - 6 )alkyl substituted by one or more of - hydroxy; preferably one or two, - methoxy, - halogen, - (C 3 - 6 )cycloalkyl, or R 1 and R 2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e. g. selected from N or O, or R 1 is hydroxy and R 2 is formyl; R 3 is OH, OR 4 , a halogen atom, or - with the proviso that R 3 is bound to 2' R 3 represents -O-(CH 2 ) p -O- with p is 2 or 3; R 4 is unsubstituted (C 1 - 6 )alkyl or (C 3 - 6 )cycloalkyl.
PT110058633T 2007-03-20 2008-03-19 Pleuromutilin derivatives for the treatment of diseases mediated by microbes PT2380874T (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07450053A EP1972618A1 (en) 2007-03-20 2007-03-20 Pleuromutilin derivatives for the treatment of diseases mediated by microbes

Publications (1)

Publication Number Publication Date
PT2380874T true PT2380874T (en) 2017-04-03

Family

ID=38668870

Family Applications (2)

Application Number Title Priority Date Filing Date
PT08714294T PT2137143E (en) 2007-03-20 2008-03-19 Pleuromutilin derivatives for the treatment of diseases mediated by microbes
PT110058633T PT2380874T (en) 2007-03-20 2008-03-19 Pleuromutilin derivatives for the treatment of diseases mediated by microbes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT08714294T PT2137143E (en) 2007-03-20 2008-03-19 Pleuromutilin derivatives for the treatment of diseases mediated by microbes

Country Status (32)

Country Link
US (12) US20090118366A1 (en)
EP (3) EP1972618A1 (en)
JP (2) JP5479114B2 (en)
KR (1) KR101478593B1 (en)
CN (2) CN104211624B (en)
AT (1) ATE523486T1 (en)
AU (1) AU2008229609B2 (en)
BR (1) BRPI0809023B8 (en)
CA (1) CA2678795C (en)
CY (2) CY1117482T1 (en)
DK (2) DK2137143T3 (en)
EA (1) EA018707B1 (en)
ES (2) ES2620459T3 (en)
FI (1) FIC20200038I1 (en)
HK (1) HK1140185A1 (en)
HR (1) HRP20110869T1 (en)
HU (1) HUS2100001I1 (en)
IL (1) IL200440A (en)
LT (1) LTPA2020531I1 (en)
MA (1) MA31314B1 (en)
MY (1) MY148916A (en)
NL (1) NL301086I2 (en)
NO (1) NO2021002I1 (en)
NZ (1) NZ579011A (en)
PL (1) PL2137143T3 (en)
PT (2) PT2137143E (en)
SI (1) SI2137143T1 (en)
TN (1) TN2009000347A1 (en)
TW (1) TWI406657B (en)
UA (1) UA97836C2 (en)
WO (1) WO2008113089A1 (en)
ZA (1) ZA200905590B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1808431A1 (en) * 2006-01-16 2007-07-18 Nabriva Therapeutics Forschungs GmbH Mutilin derivatives and their use as pharmaceutical
EP1972618A1 (en) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
EP2159220A1 (en) * 2008-09-02 2010-03-03 Nabriva Therapeutics AG Organic compounds
WO2010056855A1 (en) * 2008-11-13 2010-05-20 Teva Pharmaceutical Industries Ltd. Preparation of retapamulin via its pleuromutilin-thiol precursor
EP2399904A1 (en) * 2010-05-26 2011-12-28 Nabriva Therapeutics AG Process for the preparation of pleuromutilins
EP2390245A1 (en) * 2010-05-26 2011-11-30 Nabriva Therapeutics AG Enantiomerically pure amines
EP2433926A1 (en) 2010-09-09 2012-03-28 Nabriva Therapeutics AG Pleuromutilin derivatives for use in the treatment of diseases mediated by microbes
CN103748075B (en) 2011-07-15 2016-09-07 拜耳知识产权有限责任公司 2,3-diphenyl valeronitrile derivant, its preparation method and as herbicide and the purposes of plant growth regulator
CN103265487A (en) * 2013-06-05 2013-08-28 北京理工大学 Pleuromutilin expansion ring derivative, and preparation method and application thereof
CN104803911B (en) * 2014-01-23 2018-01-05 中国科学院上海药物研究所 A kind of pleuromutilin compound, its pharmaceutical composition, synthetic method and purposes
ES2553929B1 (en) * 2014-06-11 2016-09-26 Antonio Javier MORENO CASTRO Device for selective modification / destruction of organic tissues
PT3310331T (en) * 2015-06-17 2021-01-19 Nabriva Therapeutics GmbH Injectable pharmaceutical formulations of lefamulin
PL3310333T3 (en) 2015-06-18 2020-07-13 Estetra Sprl Orodispersible dosage unit containing an estetrol component
GEP20217308B (en) 2015-06-18 2021-10-25 Estetra Sprl Orodispersible dosage unit containing an estetrol component
TWI762573B (en) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 Purification of pleuromutilin
JOP20200260A1 (en) 2018-04-19 2019-10-19 Estetra Sprl Compounds and their uses for alleviating menopause-associated symptoms
TWI801561B (en) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 Compounds and their uses for alleviating menopause-associated symptoms
CN111170911A (en) * 2019-09-29 2020-05-19 安帝康（无锡）生物科技有限公司 Pleuromutilin compounds for treating bacterial infectious diseases
CN111170893B (en) * 2020-01-19 2022-04-26 郑州依米花手性药物研究有限公司 Lefamulin intermediate compound and application thereof in preparation of Lefamulin
CN115397407A (en) * 2020-04-17 2022-11-25 纳布里瓦治疗有限责任公司 Novel therapeutic use of pleuromutilin compounds
BR112022020007A2 (en) 2020-04-17 2022-11-22 Nabriva Therapeutics GmbH THERAPEUTIC USE OF PLEUROMUTILINS
US20230174509A1 (en) 2020-04-17 2023-06-08 Nabriva Therapeutics GmbH Therapeutic use of pleuromutilins
WO2023152115A1 (en) 2022-02-09 2023-08-17 Nabriva Therapeutics GmbH Lefamulin and its derivatives for use in the treatment of a spiral shaped bacteria
EP4338732A1 (en) 2022-09-16 2024-03-20 Nabriva Therapeutics GMBH Lefamulin and its derivatives for use in the treatment of tularemia

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130709A (en) * 1977-12-08 1978-12-19 Eli Lilly And Company Pleuromutilin glycoside derivatives
DE4023848C2 (en) 1990-07-27 1994-04-21 Huels Chemische Werke Ag Process for the preparation of 3-C¶1¶ to C¶6¶-Alkoxycarbonylcyclohexanpropionsäureestern
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
GB0207495D0 (en) 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
GB0209262D0 (en) 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
WO2004011431A1 (en) * 2002-07-24 2004-02-05 Sandoz Ag Pleuromutilin derivatives as antimicrobbials
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
EP1896404B1 (en) * 2005-06-27 2014-09-17 Nabriva Therapeutics AG Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
GB0515995D0 (en) * 2005-08-03 2005-09-07 Sandoz Ag Organic compounds
EP1972618A1 (en) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes

Also Published As

Publication number Publication date
CN101668738B (en) 2014-10-15
TN2009000347A1 (en) 2010-12-31
MY148916A (en) 2013-06-14
DK2137143T3 (en) 2012-01-02
EP2380874A2 (en) 2011-10-26
HRP20110869T1 (en) 2011-12-31
ES2620459T3 (en) 2017-06-28
US20130040954A1 (en) 2013-02-14
JP5893651B2 (en) 2016-03-23
AU2008229609A1 (en) 2008-09-25
CY2020032I2 (en) 2020-11-25
DK2380874T3 (en) 2017-03-27
US20180303842A1 (en) 2018-10-25
CY1117482T1 (en) 2017-04-26
ZA200905590B (en) 2010-10-27
EA018707B1 (en) 2013-10-30
JP5479114B2 (en) 2014-04-23
CA2678795C (en) 2014-11-18
US20220218713A1 (en) 2022-07-14
BRPI0809023A2 (en) 2014-09-23
EP2137143B1 (en) 2011-09-07
KR20090123882A (en) 2009-12-02
NO2021002I1 (en) 2021-01-15
WO2008113089A1 (en) 2008-09-25
US20170266194A1 (en) 2017-09-21
EA200970868A1 (en) 2010-02-26
US20200030335A1 (en) 2020-01-30
ES2375503T3 (en) 2012-03-01
IL200440A (en) 2013-09-30
US8071643B2 (en) 2011-12-06
US8153689B2 (en) 2012-04-10
FIC20200038I1 (en) 2020-10-01
UA97836C2 (en) 2012-03-26
SI2137143T1 (en) 2012-01-31
CA2678795A1 (en) 2008-09-25
JP2014159416A (en) 2014-09-04
BRPI0809023B1 (en) 2020-12-01
US20100035987A1 (en) 2010-02-11
CN104211624B (en) 2017-12-15
CN101668738A (en) 2010-03-10
US20140256731A1 (en) 2014-09-11
EP2380874A3 (en) 2011-12-07
AU2008229609B2 (en) 2012-03-29
PT2137143E (en) 2011-12-22
JP2010522143A (en) 2010-07-01
EP1972618A1 (en) 2008-09-24
HUS2100001I1 (en) 2021-03-01
KR101478593B1 (en) 2015-01-02
TWI406657B (en) 2013-09-01
PL2137143T3 (en) 2012-02-29
EP2137143A1 (en) 2009-12-30
CN104211624A (en) 2014-12-17
HK1140185A1 (en) 2010-10-08
US20120029072A1 (en) 2012-02-02
IL200440A0 (en) 2010-04-29
US20210113571A1 (en) 2021-04-22
BRPI0809023B8 (en) 2021-05-25
US20090118366A1 (en) 2009-05-07
US20200281933A1 (en) 2020-09-10
US20190175603A1 (en) 2019-06-13
EP2380874B1 (en) 2016-12-28
MA31314B1 (en) 2010-04-01
LTPA2020531I1 (en) 2020-11-10
ATE523486T1 (en) 2011-09-15
CY2020032I1 (en) 2020-11-25
NZ579011A (en) 2011-03-31
NL301086I2 (en) 2021-01-28
TW200904402A (en) 2009-02-01

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