PT1606293E - Cephalosporin in crystalline form - Google Patents

Cephalosporin in crystalline form Download PDF

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Publication number
PT1606293E
PT1606293E PT04720595T PT04720595T PT1606293E PT 1606293 E PT1606293 E PT 1606293E PT 04720595 T PT04720595 T PT 04720595T PT 04720595 T PT04720595 T PT 04720595T PT 1606293 E PT1606293 E PT 1606293E
Authority
PT
Portugal
Prior art keywords
crystalline form
cephalosporin
formula
mrsa
potent
Prior art date
Application number
PT04720595T
Other languages
Portuguese (pt)
Inventor
Joerg Berghausen
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of PT1606293E publication Critical patent/PT1606293E/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to cephalosporin of formula (I) in crystalline form. The compound of formula (I) in crystalline form is useful as antibiotics having potent and broad antibacterial activity; especially against methicillin resistant Staphylococci (MRSA) and Pseudomonas aeruginosa.
PT04720595T 2003-03-27 2004-03-15 Cephalosporin in crystalline form PT1606293E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03006815 2003-03-27

Publications (1)

Publication Number Publication Date
PT1606293E true PT1606293E (en) 2009-10-14

Family

ID=33040912

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04720595T PT1606293E (en) 2003-03-27 2004-03-15 Cephalosporin in crystalline form

Country Status (21)

Country Link
US (2) US7531650B2 (en)
EP (1) EP1606293B1 (en)
JP (1) JP5230934B2 (en)
KR (1) KR101121942B1 (en)
CN (1) CN1751051B (en)
AT (1) ATE440101T1 (en)
AU (1) AU2004224181B2 (en)
BR (1) BRPI0408716B1 (en)
CA (1) CA2519272C (en)
CY (1) CY1109615T1 (en)
DE (1) DE602004022643D1 (en)
DK (1) DK1606293T3 (en)
ES (1) ES2329244T3 (en)
HK (1) HK1085479A1 (en)
MX (1) MXPA05010083A (en)
PL (1) PL1606293T3 (en)
PT (1) PT1606293E (en)
SI (1) SI1606293T1 (en)
TW (1) TWI346117B (en)
WO (1) WO2004085444A1 (en)
ZA (1) ZA200507760B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006059753A1 (en) * 2004-11-30 2006-06-08 Astellas Pharma Inc. Novel oral pharmaceutical suspension of cefdinir crystal

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758350A (en) * 1969-12-30 1971-05-03 Pfizer MANUFACTURING PROCESS FOR MONO- AND BI-METALLIC ALKALINE SALTS OF ALPHA-CARBOXYBENZYLPENICILLIN
US3697506A (en) * 1970-08-07 1972-10-10 Pfizer Crystalline alkali metal salts of {60 -carboxybenzylpenicillin and process therefor
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
GR78221B (en) 1980-02-01 1984-09-26 Ciba Geigy Ag
US4432987A (en) * 1982-04-23 1984-02-21 Pfizer Inc. Crystalline benzenesulfonate salts of sultamicillin
FR2532315A1 (en) 1982-08-27 1984-03-02 Rhone Poulenc Sante CRYSTALLIZED FORMS OF ADDITION SALTS WITH ACIDS, 2- (2-AMINO-2-THIAZOLYL) METHOXYIMINO-ACETAMIDO-CARBOXY-2-DIOXO-5,6-FORMYLMETHYL-4-TETRAHYDRO-1,4 , 5.6 TRIAZINE-1,2,4 YL-3) THIO-2-VINYL) -3 OXO-8 THIA-5 AZA-1 BICYCLO (4.2.0) OCTENE-2 SYN-ISOMER, FORM E AND THEIR PREPARATION
US4634556A (en) * 1985-05-10 1987-01-06 Schering Corporation Crystalline sodium (5R, 6S, 8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylate and process for making same
AU615966B2 (en) * 1987-12-04 1991-10-17 Takeda Chemical Industries Ltd. Crystals of cephem hydrochloride
JPH02101081A (en) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd Crystalline dihydrochloride of cephalosporin derivative and production thereof
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
US5492903A (en) * 1990-06-19 1996-02-20 Takeda Chemical Industries Ltd. Crystalline esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]he
JP2575590B2 (en) * 1992-07-31 1997-01-29 塩野義製薬株式会社 Triazolylthiomethylthiocephalosporin hydrochloride and its hydrate crystals and their preparation
EP0581552B1 (en) 1992-07-31 1998-04-22 Shionogi & Co., Ltd. Triazolylthiomethylthio cephalosporin hyrochloride, its crystalline hydrate and the production of the same
KR100296810B1 (en) * 1993-03-12 2001-10-24 로렌스 티. 마이젠헬더 Crystalline Sefioferric Acid
HU224196B1 (en) * 1996-09-20 2005-06-28 Meiji Seika Kaisha Ltd. A crystalline form of cefditoren pivoxyl and process for the production of the same
TW415949B (en) 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
AU754732B2 (en) * 1998-06-15 2002-11-21 Basilea Pharmaceutica International Ag, Allschwil Derivatives of 3-(2-oxo-(1,3')bipyrrolidinyl-3-ylidenemethyl)-cephems
US6232306B1 (en) 1998-06-15 2001-05-15 Hoffmann-La Roche Inc. Derivatives of 3-(2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl)-cephams
US6504025B2 (en) * 2000-05-24 2003-01-07 Basilea Pharmaceutica Ag Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
USRE40794E1 (en) * 2001-09-26 2009-06-23 Merck & Co., Inc. Crystalline forms of carbapenem antibiotics and methods of preparation

Also Published As

Publication number Publication date
MXPA05010083A (en) 2005-11-23
TW200502237A (en) 2005-01-16
DE602004022643D1 (en) 2009-10-01
CA2519272C (en) 2010-06-08
EP1606293A1 (en) 2005-12-21
ES2329244T3 (en) 2009-11-24
BRPI0408716B8 (en) 2021-05-25
TWI346117B (en) 2011-08-01
US7531650B2 (en) 2009-05-12
CY1109615T1 (en) 2014-08-13
BRPI0408716A (en) 2006-03-07
CN1751051A (en) 2006-03-22
CA2519272A1 (en) 2004-10-07
AU2004224181B2 (en) 2011-06-02
JP5230934B2 (en) 2013-07-10
KR101121942B1 (en) 2012-03-09
PL1606293T3 (en) 2010-01-29
WO2004085444A1 (en) 2004-10-07
HK1085479A1 (en) 2006-08-25
ZA200507760B (en) 2007-06-27
DK1606293T3 (en) 2009-10-05
EP1606293B1 (en) 2009-08-19
AU2004224181A1 (en) 2004-10-07
US20060167242A1 (en) 2006-07-27
SI1606293T1 (en) 2009-10-31
JP2006521309A (en) 2006-09-21
ATE440101T1 (en) 2009-09-15
CN1751051B (en) 2010-06-09
BRPI0408716B1 (en) 2017-08-29
US8093377B2 (en) 2012-01-10
US20090192306A1 (en) 2009-07-30
KR20050111787A (en) 2005-11-28

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