PT1383863E - Tissue growth method and apparatus - Google Patents

Tissue growth method and apparatus Download PDF

Info

Publication number
PT1383863E
PT1383863E PT01271433T PT01271433T PT1383863E PT 1383863 E PT1383863 E PT 1383863E PT 01271433 T PT01271433 T PT 01271433T PT 01271433 T PT01271433 T PT 01271433T PT 1383863 E PT1383863 E PT 1383863E
Authority
PT
Portugal
Prior art keywords
flow channel
culture medium
substrate
flow
tissue
Prior art date
Application number
PT01271433T
Other languages
Portuguese (pt)
Inventor
R A Brown
G Blunn
Original Assignee
Univ London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ London filed Critical Univ London
Publication of PT1383863E publication Critical patent/PT1383863E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

Abstract

A method for growing tissue in vitro includes the steps of: (i) providing a deformable substrate which is seeded with tissue-forming cells and which defines at least one flow channel containing a fluid culture medium; (ii) applying, substantially parallel to the flow channel, a cyclically varying load to the substrate, which load deforms the substrate to provide mechanical cueing for the cells; and (iii) inhibiting the flow of culture medium in one direction of the flow channel so that the deformation of the substrate causes a net flow of the culture medium along the flow channel in the opposing direction, thereby refreshing the culture medium in the flow channel.
PT01271433T 2000-12-20 2001-12-19 Tissue growth method and apparatus PT1383863E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0031089.6A GB0031089D0 (en) 2000-12-20 2000-12-20 Tissue growth method and apparatus

Publications (1)

Publication Number Publication Date
PT1383863E true PT1383863E (en) 2008-05-21

Family

ID=9905482

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01271433T PT1383863E (en) 2000-12-20 2001-12-19 Tissue growth method and apparatus

Country Status (10)

Country Link
US (1) US20040058440A1 (en)
EP (1) EP1383863B1 (en)
AT (1) ATE386795T1 (en)
AU (1) AU2002216213A1 (en)
DE (1) DE60132923T2 (en)
DK (1) DK1383863T3 (en)
ES (1) ES2301519T3 (en)
GB (1) GB0031089D0 (en)
PT (1) PT1383863E (en)
WO (1) WO2002050242A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032205A1 (en) * 2003-08-05 2005-02-10 Smith Sidney T. In vitro cell culture employing a fibrin network in a flexible gas permeable container
EP1679366A1 (en) 2005-01-07 2006-07-12 Ecole Polytechnique Federale de Lausanne EPFL-SRI Device for cell culture on deformable surfaces
WO2013163358A1 (en) 2012-04-24 2013-10-31 Harvard Bioscience, Inc. Engineered tissue scaffolds and supports therefor
WO2014110300A1 (en) * 2013-01-09 2014-07-17 Harvard Apparatus Regenerative Technology Synthetic scaffolds
AU2017247367B2 (en) * 2016-04-04 2021-08-19 Tissueguard Gmbh Polymer-based material having covalently bonded, enzymatically degradable peptide sequences

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804628A (en) * 1984-10-09 1989-02-14 Endotronics, Inc. Hollow fiber cell culture device and method of operation
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
GB9101191D0 (en) * 1991-01-18 1991-02-27 Univ London Wound treatment
WO1994025584A1 (en) * 1993-04-28 1994-11-10 Johns Hopkins University School Of Medicine Chronic endothelial cell culture under flow
US6121042A (en) * 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
WO1998001810A2 (en) * 1996-07-08 1998-01-15 Philips Electronics N.V. Method for speeding up an iterative search in a list of records residing on a slow background memory
US6037141A (en) * 1998-06-04 2000-03-14 Banes; Albert J. Culture compression device

Also Published As

Publication number Publication date
ATE386795T1 (en) 2008-03-15
AU2002216213A1 (en) 2002-07-01
WO2002050242A2 (en) 2002-06-27
DK1383863T3 (en) 2008-06-09
EP1383863B1 (en) 2008-02-20
GB0031089D0 (en) 2001-01-31
US20040058440A1 (en) 2004-03-25
DE60132923D1 (en) 2008-04-03
ES2301519T3 (en) 2008-07-01
WO2002050242A3 (en) 2003-11-06
DE60132923T2 (en) 2009-02-26
EP1383863A2 (en) 2004-01-28

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