PT1338596E - PROCESSES FOR THE PREPARATION OF ANTIBACTERIAL AGENTS OF THE CARBAPENEM TYPE - Google Patents

PROCESSES FOR THE PREPARATION OF ANTIBACTERIAL AGENTS OF THE CARBAPENEM TYPE

Info

Publication number
PT1338596E
PT1338596E PT01982847T PT01982847T PT1338596E PT 1338596 E PT1338596 E PT 1338596E PT 01982847 T PT01982847 T PT 01982847T PT 01982847 T PT01982847 T PT 01982847T PT 1338596 E PT1338596 E PT 1338596E
Authority
PT
Portugal
Prior art keywords
preparation
processes
antibacterial agents
carbapenem
carbapenem type
Prior art date
Application number
PT01982847T
Other languages
Portuguese (pt)
Inventor
Fujimoto Katsuhiko
Kasai Takashi
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of PT1338596E publication Critical patent/PT1338596E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A process for the preparation of a carbapenem-type antibacterial agent of formula (4) having a 1-alkylpyrrolidine structure or a salt thereof, a useful synthetic intermediate of formula (1) or a salt thereof, and a process for the preparation thereof: <CHEM> Äwherein R<1> represents a C1-C3 alkyl group, R<2> and R<3> each independently represents a hydrogen atom or the likeÜ.
PT01982847T 2000-11-20 2001-11-19 PROCESSES FOR THE PREPARATION OF ANTIBACTERIAL AGENTS OF THE CARBAPENEM TYPE PT1338596E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000352178 2000-11-20

Publications (1)

Publication Number Publication Date
PT1338596E true PT1338596E (en) 2006-05-31

Family

ID=18825114

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01982847T PT1338596E (en) 2000-11-20 2001-11-19 PROCESSES FOR THE PREPARATION OF ANTIBACTERIAL AGENTS OF THE CARBAPENEM TYPE

Country Status (15)

Country Link
US (2) US7034150B2 (en)
EP (1) EP1338596B1 (en)
KR (1) KR100825243B1 (en)
CN (1) CN1247581C (en)
AT (1) ATE315568T1 (en)
AU (1) AU2002214325A1 (en)
CA (1) CA2429071A1 (en)
CY (1) CY1105598T1 (en)
DE (1) DE60116656T2 (en)
DK (1) DK1338596T3 (en)
ES (1) ES2256311T3 (en)
HK (1) HK1054745A1 (en)
PT (1) PT1338596E (en)
TW (1) TWI290925B (en)
WO (1) WO2002040482A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006101062A1 (en) * 2005-03-22 2006-09-28 Daiichi Sankyo Company, Limited Process for producing carbapenem derivative having 1-alkylpyrrolidine structure
CN101328178B (en) * 2007-06-15 2010-10-13 山东轩竹医药科技有限公司 Penem derivates containing thiophen substituted sulfhydryl pyrrolidine
CN101357919B (en) * 2007-06-22 2011-06-15 山东轩竹医药科技有限公司 Penem derivative containing sulfhydryl formamide benzenesulfonyl pyrrolidine
CN101333219B (en) * 2007-06-26 2010-10-13 山东轩竹医药科技有限公司 Penem derivates with mercapto pyrrolidine formamide benzene alkyl heterocycle
CN101367812B (en) * 2007-06-28 2011-04-27 山东轩竹医药科技有限公司 Sulfhydryl pyrrolidine formamido cyclopentene acid substituted penem derivant
CN101343271B (en) * 2007-07-13 2011-01-12 山东轩竹医药科技有限公司 Penem derivant containing isoxazole alkyl ketone
ES2952384T3 (en) * 2009-12-04 2023-10-31 Becton Dickinson Co Pen needle removal device for a drug delivery device
CN102002069A (en) * 2010-11-12 2011-04-06 上海巴迪生物医药科技有限公司 Preparation method of dicyclic intermediate for synthesizing carbapenem side chains and application thereof
JP6364025B2 (en) * 2013-01-15 2018-07-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Acylguanidine for the treatment of osteoarthritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491541A (en) * 1982-11-10 1985-01-01 Farmitalia Carlo Erba Peptides
US4958029A (en) * 1987-01-13 1990-09-18 Banyu Pharmaceutical Co., Ltd. Process for the production of isoindoline derivatives, novel intermediates and process for their production
GB8809736D0 (en) * 1988-04-25 1988-06-02 Fujisawa Pharmaceutical Co New cephem compounds & process for preparation thereof
JP3091297B2 (en) * 1992-01-10 2000-09-25 住友製薬株式会社 Pyrrolidine derivative and method for producing the same
ATE223411T1 (en) * 1995-12-21 2002-09-15 Sankyo Co 1-METHYLCARBAPENEM DERIVATIVES
US5952338A (en) * 1996-07-05 1999-09-14 Takeda Chemical Industries, Ltd. Agent for prophylaxis and treatment of disturbance of visual function
JP2955276B2 (en) 1997-06-19 1999-10-04 三共株式会社 Antibacterial agent containing 1-methylcarbapenem derivative
US6063931A (en) * 1997-07-09 2000-05-16 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
AU731586B2 (en) * 1997-07-09 2001-04-05 Merck Sharp & Dohme Corp. Process for synthesizing carbapenem side chain intermediates
JP4548335B2 (en) * 2003-03-07 2010-09-22 味の素株式会社 Inducing agent for converting intestinal cells into insulin-producing cells, and therapeutic agent for diabetes

Also Published As

Publication number Publication date
TWI290925B (en) 2007-12-11
EP1338596A1 (en) 2003-08-27
CA2429071A1 (en) 2002-05-23
US20030225055A1 (en) 2003-12-04
DE60116656D1 (en) 2006-04-06
DK1338596T3 (en) 2006-04-18
KR100825243B1 (en) 2008-04-25
US20060009508A1 (en) 2006-01-12
KR20030097793A (en) 2003-12-31
AU2002214325A1 (en) 2002-05-27
CY1105598T1 (en) 2010-07-28
US7034150B2 (en) 2006-04-25
DE60116656T2 (en) 2006-09-21
WO2002040482A1 (en) 2002-05-23
EP1338596B1 (en) 2006-01-11
US7091363B2 (en) 2006-08-15
ES2256311T3 (en) 2006-07-16
ATE315568T1 (en) 2006-02-15
CN1247581C (en) 2006-03-29
EP1338596A4 (en) 2004-08-04
CN1486316A (en) 2004-03-31
HK1054745A1 (en) 2003-12-12

Similar Documents

Publication Publication Date Title
DE69924751D1 (en) CEPHEM COMPOUNDS WITH AN IMIDAZO [4,5-B] PYRIDINIUM METHYL REST HAVING A WIDE ANTIBACTERIAL EFFECT SPECTRUM
ES2110749T3 (en) AZOLYLAMINE DERIVATIVE.
AP1753A (en) Thiophene derivatives as antiviral agents for flavvivirus infection
PT1159279E (en) 4-OXO-4,7-DIHYDROTIENE-2,3-B | PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS
DE60027015D1 (en) Pseudoerythromycin-derivate
DK0920421T3 (en) Isoxazoline derivatives useful as antimicrobial agents
PT1063228E (en) DERIVATIVES OF CICLOALCENOS PROCESS FOR THEIR PREPARATION AND USE
CY1105598T1 (en) METHODS FOR THE PREPARATION OF CARBAPENEM-TYPE ANTIBACTERIAL AGENTS
ATE172463T1 (en) PYRROLOCARBAZOLE
BR0101230A (en) Process for the preparation of 11-amino-3-chloro-6,11-dihydro-5-5-dioxo-6-methyl-dibenzo [c, f] [1,2] thiazepine and application for the synthesis of detianeptine
DE60223227D1 (en) BenzoÄbÄthiophenderivate and process for their preparation
PT1268475E (en) NEW BACTERIAL AGENTS OF BENZOSULTAM-OXAZOLIDINONE
BR9902096A (en) Pitazoles.
DE60330038D1 (en) NEW ALPHA-KETOAMIDE DERIVATIVES AND THEIR USE
FI921475A0 (en) 1,4-DIHYDRO-4-OXO-3-QUINOL DERIVATIVES WITH SELECTIVE TOXIC ANTIBACTERIA AEMENN HOS DAEGGDJUR.
TH61861A3 (en) 4-Oxo-1,4-dihydro-3-quinoline carboxamides as antiviral agents
GT199400033A (en) ANTIBACTERIAL COMPOUNDS (CEPHALOSPORIN DERIVATIVES)
TH68928A (en) Antibacterial agents
BRPI9917841B8 (en) substituted 3-cyano quinoline compounds and compositions comprising the same