PT116932A - DECELLULARIZED FETAL MATERIAL FROM THE PULPUS NUCLEUS AND METHODS FOR OBTAINING PHARMACEUTICAL COMPOSITIONS TO BE USED IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION AND BACK PAIN - Google Patents

DECELLULARIZED FETAL MATERIAL FROM THE PULPUS NUCLEUS AND METHODS FOR OBTAINING PHARMACEUTICAL COMPOSITIONS TO BE USED IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION AND BACK PAIN

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Publication number
PT116932A
PT116932A PT116932A PT11693220A PT116932A PT 116932 A PT116932 A PT 116932A PT 116932 A PT116932 A PT 116932A PT 11693220 A PT11693220 A PT 11693220A PT 116932 A PT116932 A PT 116932A
Authority
PT
Portugal
Prior art keywords
treatment
methods
decellularized
div
pulpus
Prior art date
Application number
PT116932A
Other languages
Portuguese (pt)
Inventor
Adolfo Monteiro Da Rocha Barbosa Mário
Caldeira Fernandes Frey Ramos Joana
Madeira Gonçalves Raquel
Francesca Fiordalisi Morena
Original Assignee
Ineb Instituto Nac De Engenharia Biomedica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ineb Instituto Nac De Engenharia Biomedica filed Critical Ineb Instituto Nac De Engenharia Biomedica
Priority to PT116932A priority Critical patent/PT116932A/en
Priority to US17/783,875 priority patent/US20230026427A1/en
Priority to EP20829234.2A priority patent/EP4072608A1/en
Priority to BR112022011557A priority patent/BR112022011557A2/en
Priority to PCT/PT2020/050049 priority patent/WO2021118379A1/en
Publication of PT116932A publication Critical patent/PT116932A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A61L27/3658—Intervertebral discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A PRESENTE INVENÇÃO REFERE-SE À UTILIZAÇÃO ALOGÉNICA DE UM MATERIAL DE ORIGEM FETAL DESCELULARIZADO DO NÚCLEO PULPOSO (NP) PARA A REGENERAÇÃO DO DISCO INTERVERTEBRAL (DIV) DE UM HOSPEDEIRO. EM PARTICULAR, A PRESENTE INVENÇÃO REFERE-SE A UM BIOMATERIAL OBTIDO DE UM NP DESCELULARIZADO DE UM FETO VERTEBRADO E CARACTERIZADO POR COMPREENDER ALTOS NÍVEIS DE COLAGÉNIO DOS TIPOS 12 E 14, E A UMA COMPOSIÇÃO FARMACÊUTICA PARA SER USADA NO TRATAMENTO DE DEGENERAÇÃO DO DIV. A INVENÇÃO BASEIA-SE NA CAPACIDADE AUMENTADA DO DITO BIOMATERIAL FETAL DESCELULARIZADO PARA ESTIMULAR A EXPRESSÃO DE COLAGÉNIO TIPO 2 E AGRECANO PELAS CÉLULAS CONSTITUINTES DO HOSPEDEIRO, PROMOVENDO A REGENERAÇÃO INTRÍNSECA DO DIV. A PRESENTE INVENÇÃO REFERE-SE AINDA AOS MÉTODOS PARA PREPARAR UM MODO DE ADMINISTRAÇÃO INJETÁVEL DAS REFERIDAS COMPOSIÇÕES FARMACÊUTICAS DE BIOMATERIAL FETAL DESCELULARIZADO, NA FORMA DE MICROFRAGMENTOS E HIDROGEL. O USO DO MATERIAL, DA COMPOSIÇÃO FARMACÊUTICA E DOS MÉTODOS DA PRESENTE INVENÇÃO PODEM SER VANTAJOSAMENTE UTILIZADOS PARA O TRATAMENTO DA DEGENERAÇÃO DO DIV E DORES NAS COSTAS.THE PRESENT INVENTION CONCERNS THE ALLOGENIC USE OF A PULPUS NUCLEUS (NP) FETAL ORIGIN MATERIAL FOR THE REGENERATION OF A HOST'S INTERVERTEBRAL DISK (DIV). IN PARTICULAR, THE PRESENT INVENTION CONCERNS A BIOMATERIAL OBTAINED FROM A DECELLULARIZED NP OF A VERTEBRATE FETUS AND CHARACTERIZED BY COMPRISING HIGH LEVELS OF COLLAGEN OF TYPES 12 AND 14, AND A PHARMACEUTICAL COMPOSITION TO BE USED IN THE TREATMENT OF DIV DEGENERATION. THE INVENTION IS BASED ON THE INCREASED CAPACITY OF SUCH DECELLULARIZED FETAL BIOMATERIAL TO STIMULATE THE EXPRESSION OF COLLAGEN TYPE 2 AND AGRECAN BY THE CONSTITUENT CELLS OF THE HOST, PROMOTING THE INTRINSIC REGENERATION OF THE DIV. THE PRESENT INVENTION FURTHER RELATES TO METHODS FOR PREPARING A METHOD OF INJECTABLE ADMINISTRATION OF SUCH PHARMACEUTICAL COMPOSITIONS OF DECELLULARIZED FETAL BIOMATERIAL, IN THE FORM OF MICROFRAGMENTS AND HYDROGEL. USE OF THE MATERIAL, PHARMACEUTICAL COMPOSITION AND METHODS OF THE PRESENT INVENTION MAY BE USED TO ADVANTAGEOUSLY FOR THE TREATMENT OF DIV DEGENERATION AND BACK PAIN.

PT116932A 2019-12-12 2020-12-10 DECELLULARIZED FETAL MATERIAL FROM THE PULPUS NUCLEUS AND METHODS FOR OBTAINING PHARMACEUTICAL COMPOSITIONS TO BE USED IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION AND BACK PAIN PT116932A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
PT116932A PT116932A (en) 2020-12-10 2020-12-10 DECELLULARIZED FETAL MATERIAL FROM THE PULPUS NUCLEUS AND METHODS FOR OBTAINING PHARMACEUTICAL COMPOSITIONS TO BE USED IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION AND BACK PAIN
US17/783,875 US20230026427A1 (en) 2019-12-12 2020-12-14 Fetal decellularized nucleus pulposus material and methods for obtaining pharmaceutic compositions to be used in the treatment of intervertebral disc degeneration and back pain
EP20829234.2A EP4072608A1 (en) 2019-12-12 2020-12-14 Fetal decellularized nucleus pulposus material and methods for obtaining pharmaceutic compositions to be used in the treatment of intervertebral disc degeneration and back pain
BR112022011557A BR112022011557A2 (en) 2019-12-12 2020-12-14 DECELLULARIZED FETAL MATERIAL FROM THE PULPUS NUCLEUS AND METHODS FOR OBTAINING PHARMACEUTICAL COMPOSITIONS TO BE USED IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION AND BACK PAIN
PCT/PT2020/050049 WO2021118379A1 (en) 2019-12-12 2020-12-14 Fetal decellularized nucleus pulposus material and methods for obtaining pharmaceutic compositions to be used in the treatment of intervertebral disc degeneration and back pain

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT116932A PT116932A (en) 2020-12-10 2020-12-10 DECELLULARIZED FETAL MATERIAL FROM THE PULPUS NUCLEUS AND METHODS FOR OBTAINING PHARMACEUTICAL COMPOSITIONS TO BE USED IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION AND BACK PAIN

Publications (1)

Publication Number Publication Date
PT116932A true PT116932A (en) 2022-06-14

Family

ID=82399683

Family Applications (1)

Application Number Title Priority Date Filing Date
PT116932A PT116932A (en) 2019-12-12 2020-12-10 DECELLULARIZED FETAL MATERIAL FROM THE PULPUS NUCLEUS AND METHODS FOR OBTAINING PHARMACEUTICAL COMPOSITIONS TO BE USED IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION AND BACK PAIN

Country Status (1)

Country Link
PT (1) PT116932A (en)

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Effective date: 20210713