PT110699A - NEW POLYMORPHIC FORMS OF MINOCYCLINE BASE AND PEOCCESS FOR PREPARATION. - Google Patents

NEW POLYMORPHIC FORMS OF MINOCYCLINE BASE AND PEOCCESS FOR PREPARATION.

Info

Publication number
PT110699A
PT110699A PT110699A PT11069915A PT110699A PT 110699 A PT110699 A PT 110699A PT 110699 A PT110699 A PT 110699A PT 11069915 A PT11069915 A PT 11069915A PT 110699 A PT110699 A PT 110699A
Authority
PT
Portugal
Prior art keywords
polymorphic forms
minocycline
peoccess
preparation
new polymorphic
Prior art date
Application number
PT110699A
Other languages
Portuguese (pt)
Other versions
PT110699B (en
Original Assignee
Hovione Farm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Farm Sa filed Critical Hovione Farm Sa
Priority to PT110699A priority Critical patent/PT110699B/en
Publication of PT110699A publication Critical patent/PT110699A/en
Publication of PT110699B publication Critical patent/PT110699B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/24—Tetrahydroxylic alcohols, e.g. pentaerythritol

Abstract

A PRESENTE INVENÇÃO DIZ RESPEITO A NOVAS FORMAS DE MINOCICLINA BASE CRISTALINA. EM PARTICULAR, DUAS FORMAS POLIMÓRFICAS CRISTALINAS SÃO APRESENTADAS, DESIGNADAS COMO FORMA IV E FORMA V DE MINOCICLINA BASE. ESTAS SÃO CARACTERIZADAS POR RAIO X (RX), FTIR (ESPECTROSCOPIA DE INFRAVERMELHO POR TRANSFORMADA DE FOUNIER) E TERMOGRAVIMETRIA (TVA). OS PROCESSOS PARA PREPARAR AS NOVAS FORMAS POLIMÓRFICAS E A SUA UTILIZAÇÃO EM COMPOSIÇÃO FARMACÊUTICAS TAMBÉM SÃO APRESENTADOS. A FORMA IV E FORMA V SÃO PREPARADAS POR DISOLUÇÃO E/OU SUSPENSÃO DE MINOCICLINA BASE NUM SOLVENTE ORGÂNICO, SEGUIDA DE CRISTALIZAÇÃO.The present invention relates to new forms of crystalline-based minocycline. IN PARTICULAR, TWO CRYSTALLINE POLYMORPHIC FORMS ARE PRESENTED DESIGNED AS FORM IV AND FORM V OF MINOCYCLINE BASE. THESE ARE CHARACTERIZED BY X-RAY (RX), FTIR (FOUNIER TRANSFORM TRANSFORMED SPECTROSCOPY) AND THERMOGRAVIMETRY (TVA). PROCESSES TO PREPARE NEW POLYMORPHIC FORMS AND THEIR USE IN PHARMACEUTICAL COMPOSITION ARE ALSO PRESENTED. Form IV and Form V are prepared by dissolving and / or suspending minocycline on the basis of an organic solvent followed by crystallization.

PT110699A 2015-02-13 2015-02-13 NEW POLYMORPHIC FORM OF BASE MINOCYCLINE AND PROCESSES FOR ITS PREPARATION PT110699B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PT110699A PT110699B (en) 2015-02-13 2015-02-13 NEW POLYMORPHIC FORM OF BASE MINOCYCLINE AND PROCESSES FOR ITS PREPARATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT110699A PT110699B (en) 2015-02-13 2015-02-13 NEW POLYMORPHIC FORM OF BASE MINOCYCLINE AND PROCESSES FOR ITS PREPARATION

Publications (2)

Publication Number Publication Date
PT110699A true PT110699A (en) 2018-08-02
PT110699B PT110699B (en) 2021-06-30

Family

ID=67212339

Family Applications (1)

Application Number Title Priority Date Filing Date
PT110699A PT110699B (en) 2015-02-13 2015-02-13 NEW POLYMORPHIC FORM OF BASE MINOCYCLINE AND PROCESSES FOR ITS PREPARATION

Country Status (1)

Country Link
PT (1) PT110699B (en)

Also Published As

Publication number Publication date
PT110699B (en) 2021-06-30

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 20180730

FG3A Patent granted, date of granting

Effective date: 20210625