PT1102745E - PROCESS FOR THE PREPARATION OF CALCIUM SALT OF ZOFENOPRIL - Google Patents
PROCESS FOR THE PREPARATION OF CALCIUM SALT OF ZOFENOPRILInfo
- Publication number
- PT1102745E PT1102745E PT99939416T PT99939416T PT1102745E PT 1102745 E PT1102745 E PT 1102745E PT 99939416 T PT99939416 T PT 99939416T PT 99939416 T PT99939416 T PT 99939416T PT 1102745 E PT1102745 E PT 1102745E
- Authority
- PT
- Portugal
- Prior art keywords
- zofenopril
- salt
- calcium salt
- preparation
- potassium salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F11/00—Compounds of calcium, strontium, or barium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Geology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A process for the preparation of polymorph A of zofenopril calcium salt in substantially pure form, which comprises: 1) reaction of S(-)-3-benzoylthio-2-methylpropanoic acid chloride with cis-4-phenylthio-L-proline in water at pH ranging from 9.0 to 9.5 and recovery of zofenopril in the acidic form; b) salification of acid zofenopril with a poyassium salt in alcoholic solution, and recovery of the resulting potassium salt; c) conversion of the potassium salt to the calcium salt by addition of zofenopril potassium salt aqueous solution to a CaCl2 aqueous solution at a temperature of 70-90° C. with simultaneous seeding to promote the precipitation of polymorph A.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1998MI001833A IT1301993B1 (en) | 1998-08-04 | 1998-08-04 | PROCESS FOR THE PREPARATION OF ZOFENOPRIL CALCIUM SALT. |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1102745E true PT1102745E (en) | 2004-08-31 |
Family
ID=11380611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99939416T PT1102745E (en) | 1998-08-04 | 1999-07-30 | PROCESS FOR THE PREPARATION OF CALCIUM SALT OF ZOFENOPRIL |
Country Status (32)
Country | Link |
---|---|
US (2) | US6521760B1 (en) |
EP (1) | EP1102745B1 (en) |
JP (1) | JP2002522417A (en) |
KR (1) | KR100593428B1 (en) |
CN (1) | CN1146538C (en) |
AT (1) | ATE266635T1 (en) |
AU (1) | AU5372299A (en) |
BG (1) | BG65022B1 (en) |
BR (1) | BR9912842A (en) |
CA (1) | CA2339283C (en) |
CU (1) | CU23171A3 (en) |
CZ (1) | CZ301908B6 (en) |
DE (1) | DE69917282T2 (en) |
DK (1) | DK1102745T3 (en) |
EA (1) | EA003454B1 (en) |
EE (1) | EE04798B1 (en) |
ES (1) | ES2221417T3 (en) |
HK (1) | HK1039616B (en) |
HR (1) | HRP20010083B1 (en) |
HU (1) | HU227557B1 (en) |
IL (1) | IL141222A0 (en) |
IT (1) | IT1301993B1 (en) |
NO (1) | NO319773B1 (en) |
PL (1) | PL193828B1 (en) |
PT (1) | PT1102745E (en) |
RS (1) | RS49768B (en) |
SI (1) | SI1102745T1 (en) |
SK (1) | SK285527B6 (en) |
TR (1) | TR200100272T2 (en) |
UA (1) | UA65628C2 (en) |
WO (1) | WO2000007984A1 (en) |
ZA (1) | ZA200100907B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007003963A1 (en) * | 2005-07-01 | 2007-01-11 | Generics [Uk] Limited | Zofenopril calcium in polymorph form c |
EA012845B1 (en) * | 2005-12-09 | 2009-12-30 | Менарини Интернэшнл Оперейшнс Люксембург С. А. | Pharmaceutical compositions comprising zofenopril and hctz for treating hypertension |
WO2007138352A1 (en) * | 2006-05-26 | 2007-12-06 | Generics (Uk) Limited | Zofenopril calcium |
GB0715626D0 (en) * | 2007-08-10 | 2007-09-19 | Generics Uk Ltd | Crystalline form of zofenopril calcium |
US8853421B2 (en) | 2008-02-27 | 2014-10-07 | Generics [Uk] Limited | Crystalline forms of zofenopril calcium |
JP5530369B2 (en) * | 2008-02-27 | 2014-06-25 | ジェネリクス・[ユーケー]・リミテッド | New crystal form |
WO2010084515A2 (en) * | 2009-01-23 | 2010-07-29 | Glenmark Generics Limited | A process for the preparation of zofenopril and its pharmaceutically acceptable salts thereof |
SI23949A (en) | 2011-12-19 | 2013-06-28 | Silverstone Pharma | The new crystalline salts of zofenopril, the procedure for obtaining them and their use in therapy |
CN104138359B (en) * | 2013-05-06 | 2016-03-02 | 扬子江药业集团上海海尼药业有限公司 | The preparation method of zofenopril calcium tablet |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4154935A (en) * | 1978-02-21 | 1979-05-15 | E. R. Squibb & Sons, Inc. | Halogen substituted mercaptoacylamino acids |
US4316906A (en) | 1978-08-11 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of substituted prolines |
-
1998
- 1998-08-04 IT IT1998MI001833A patent/IT1301993B1/en active IP Right Grant
-
1999
- 1999-07-30 EE EEP200100065A patent/EE04798B1/en unknown
- 1999-07-30 PT PT99939416T patent/PT1102745E/en unknown
- 1999-07-30 SI SI9930575T patent/SI1102745T1/en unknown
- 1999-07-30 AU AU53722/99A patent/AU5372299A/en not_active Abandoned
- 1999-07-30 RS YUP-75/01A patent/RS49768B/en unknown
- 1999-07-30 KR KR1020017001379A patent/KR100593428B1/en not_active IP Right Cessation
- 1999-07-30 JP JP2000563619A patent/JP2002522417A/en active Pending
- 1999-07-30 WO PCT/EP1999/005461 patent/WO2000007984A1/en active IP Right Grant
- 1999-07-30 CZ CZ20010408A patent/CZ301908B6/en not_active IP Right Cessation
- 1999-07-30 EP EP99939416A patent/EP1102745B1/en not_active Expired - Lifetime
- 1999-07-30 DE DE69917282T patent/DE69917282T2/en not_active Expired - Lifetime
- 1999-07-30 US US09/762,054 patent/US6521760B1/en not_active Expired - Fee Related
- 1999-07-30 SK SK163-2001A patent/SK285527B6/en not_active IP Right Cessation
- 1999-07-30 AT AT99939416T patent/ATE266635T1/en active
- 1999-07-30 IL IL14122299A patent/IL141222A0/en not_active IP Right Cessation
- 1999-07-30 PL PL99345814A patent/PL193828B1/en unknown
- 1999-07-30 ES ES99939416T patent/ES2221417T3/en not_active Expired - Lifetime
- 1999-07-30 CN CNB998105171A patent/CN1146538C/en not_active Expired - Lifetime
- 1999-07-30 TR TR2001/00272T patent/TR200100272T2/en unknown
- 1999-07-30 CA CA002339283A patent/CA2339283C/en not_active Expired - Lifetime
- 1999-07-30 UA UA2001010590A patent/UA65628C2/en unknown
- 1999-07-30 EA EA200100095A patent/EA003454B1/en not_active IP Right Cessation
- 1999-07-30 DK DK99939416T patent/DK1102745T3/en active
- 1999-07-30 BR BR9912842-0A patent/BR9912842A/en not_active Application Discontinuation
- 1999-07-30 HU HU0103826A patent/HU227557B1/en unknown
-
2001
- 2001-01-24 BG BG105176A patent/BG65022B1/en unknown
- 2001-02-01 HR HR20010083A patent/HRP20010083B1/en not_active IP Right Cessation
- 2001-02-01 NO NO20010552A patent/NO319773B1/en not_active IP Right Cessation
- 2001-02-01 CU CU20010032A patent/CU23171A3/en unknown
- 2001-02-01 ZA ZA200100907A patent/ZA200100907B/en unknown
-
2002
- 2002-02-21 HK HK02101248.6A patent/HK1039616B/en not_active IP Right Cessation
- 2002-05-28 US US10/155,129 patent/US6515012B2/en not_active Expired - Fee Related
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