PT104086A - PROCESS FOR MONITORING THE SUCCESS OF THE APPLICATION OF A FLUID TO A NON-STATIC BIOLOGICAL TARGET AND SYSTEM FOR ITS IMPLEMENTATION - Google Patents

Abstract

The present invention relates to a process for monitoring the success of the application of a fluid dispensed by a container 33 for dispensing fluids inserted in a device 1 to a target, comprising the following steps: a) detection of the inclination of the device 1; B) ISSUING AN ALARM WHEN THE INCLINATION OF DEVICE 1 ACHIEVES A CERTAIN VALUE; C) DETECTION OF A PRESSURE INCREASE IN THE CONTAINER 33 FOR DISPENSING FLUIDS; D) VERIFICATION OF THE SIMULTANEOUS OCCURRENCE OF THE INCLINATION ALARM AND THE PRESSURE INCREASE IN THE CONTAINER TO DISPOSE FLUIDS; E) SYNCHRONIZATION OF THE BEGINNING OF THE ACQUISITION OF IMAGES WITH THE OCCURRENCE OF THE STATE DESCRIBED IN D); F) ELECTRONIC CAPTURE OF A PLURALITY OF IMAGES OF THE ACT OF ADMINISTRATION OF THE SUBSTANCE, IN WHICH THE IMAGES CORRESPOND TO DIFFERENT AND SEQUENTIAL INSTANTS; G) ANALYSIS OF IMAGES COLLECTED TO DETERMINE THE STATE OF THE TARGET; H) ANALYSIS OF IMAGES FOR TARGET IDENTIFICATION; I) ANALYSIS OF IMAGES TO DETERMINE THE DROP LOCATION AT EACH INSTANT; J) RELATIONSHIP OF THE ANALYSIS OF G), H) AND I) TO DETERMINE THE SUCCESS OF DROP APPLICATION; K) EXPOSURE OF RESULTS. The invention further relates to a system for the implementation of the above-referenced process.

Description

1

DESCRIPTION

" PROCESS FOR MONITORING THE SUCCESS OF THE APPLICATION OF A FLUID TO A NON-STATIC BIOLOGICAL TARGET AND SYSTEM FOR ITS PERFORMANCE "

Field of the Invention The invention described herein relates to a method of monitoring the success of applying a fluid to a non-static biological target and to a system for its execution. More particularly, the invention relates to a system and device for supporting the application of a drop in the eye, and to allow evaluation of the correct application thereof.

problem description

In general, compliance with medical prescription by patients is always a mystery for doctors, where the only method of knowing if the patient took the medications in the days and times provided is to trust the word of this.

In the specialty of ophthalmology, to this problem is added the difficulty inherent in the task of putting drops into the eyes, so that there is already a panoply of 2 devices and methods to help put drops into the eyes.

However, while there are already a number of devices to assist in the application of gout, or to validate adherence to the therapeutic indications in the patient by monitoring the date and time of dropping of the bottle, or in less evolved systems, the date and time in that it is pressed, the correct application of the drop remains an unknown.

Due to difficulties in handling or others, the delicate alignment of the bottle with the eye can be compromised, and it is possible that, however cooperative a patient may be, the latter can not correctly apply the drop to the eye.

Even in the event that this alignment is correct, the fact that the eye is not adequately open at the moment the drop hits it can invalidate the application of an ophthalmic drop.

In the special case of clinical trials, there is the validation component of the person where the drop was applied. Once volunteers are paid for their participation, there may be attempts to simulate the correct participation in a trial solely for financial reasons. BACKGROUND ART The existing literature reveals several attempts to facilitate the application of drops. These approaches invariably relate to the creation of support parts for fixing the position of the vial relative to the eye (WO200 (6) 12 (6) 971, W020070 (6) 23 (6) 1, WO9320785, among many others). or devices to facilitate the handling of bottles (OPTICARE®, W020040803 (6) 7). Regarding the attempt to validate the correct application of gout, there are approaches where the date and time the bottle is pressed is controlled (W020040803 (6) 7, GB2434902), the main disadvantage of these methods being that depending of the volume of fluid within the vial, and the duration of the pressure therein, the number of drops exiting said vial is variable.

This limitation makes them simple " dike counters " with the ability to memorize their date.

These pressure counting approaches have been partially improved with US5152424, where a transducer is used to detect the passage of the drop through the vial outlet. 4

However, none of these systems can guarantee or allow an assessment of whether the drop actually reached the eye.

Summary of the Invention

This invention aims at the design of a system for validating the correct application of preferably ophthalmic drops, having additional capabilities to support the action of placing them, which system consists essentially of a portable device and a remote computing platform. It is also an object of the invention to provide a method of monitoring the success of applying a fluid to a non-static biological target.

This system object of the invention consists of a device equipped with a means for containing a dropper bottle, and provided with a video camera and physical memory capable of recording video sequences corresponding to the course of a drop when it is applied since exiting the bottle until the moment it reaches (or fails) the eye, as well as to a remote computing platform and Remote Software for visualization by another user with the purpose of analyzing the occurrence. The device further comprises a tilt sensor which in conjunction with a controller enables the user of the eyedropper bottle to be warned of the indicated angle to start applying it. The acquired video is processed with signal and image processing algorithms for the extraction of the iris region, the level of eyelid opening, and the location of the drop at each instant.

The data collected by the handheld device is sent to a remote computing platform and Remote Software for viewing by another controlling user with the function of analyzing the occurrence.

BRIEF DESCRIPTION OF THE DRAWINGS The following description is based on the accompanying drawings in which, without being limiting in any way, they are shown: - In Figure 1, an overall view of the device with a support placed; In Figure 2, a detail of a support for securing the distance from the device to the target; In Figure 3, the body of the device according to an axial section; In Figure 4, a plan view of the device;

In Figure 5, a main elevational view of the device;

In Figure 6, a side elevational view of the device; 6

In Figure 7, a schematic and conceptual representation of the electronic components present in the circuitry of the device; In Figure 8, a front perspective view of a possible alternative configuration for this device; In Figure 9, a side perspective view of the alternative configuration for this device; - In Figure 10, the problem of component alignment. -In Figure 11, the sequence of operations in order to configure the system.

Detailed description of the invention

For illustrative purposes, and not limiting the generality, the present invention will be described in detail with reference to the accompanying figures. This invention is not limited in its application to the details of construction and organization of the components described or illustrated below. The invention may have other embodiments and may be created and implemented in other ways. Such modifications will be apparent to those skilled in the art having ordinary skill. Likewise, the terminology and syntax used serve the purpose of the indicative description and should not be construed as limiting. The use of ", ", ", ", ", ", ", ", ", ", " involving ", and variations thereof, is meant to encompass the above mentioned items, as well as equivalents. The present invention relates to a process for monitoring the success of applying a fluid dispensed by a fluid dispensing container (33) inserted in a device (1) to a target, comprising the following steps: a) Detection of the slope of the device (1); b) Issuing an alarm when the inclination of the device (1) reaches a certain value; c) detecting a pressure increase in the container (33) for dispensing fluids; d) Verification of the simultaneous occurrence of the tilt alarm and the increase of pressure in the vessel to dispense fluids; e) Synchronization of the beginning of the acquisition of images with the occurrence of the state described in d); f) Electronic capture of a plurality of images of the act of administration of the substance, in which the images correspond to distinct and sequential instants; g) Analysis of the collected images to determine the state of the target; h) Analysis of the images to identify the target; i) Analysis of the images to determine the location of the drop at each moment; j) Relationship of the analyzes of h), i) and j) to determine the success of the application of gout; k) Exposure of results

In order to carry out the above-mentioned steps, a system for validating the application of a fluid to a target is essentially composed of two elements: a portable device 1, and a Computer (40) equipped with peripherals and specific software.

Essentially said system is constituted by a device (1) which is provided with: a) Means (32) for containing a container (33) for dispensing fluids; b) an element (2) for fixing the position between the target and the device of the (1); c) Means (6) to acquire images; d) Means (9) for permanently storing digital data consisting of a ROM; e) A circuit (8) for compressing data from the c) means; f) an electric sensor (15) for evaluating the inclination of the device (1); g) Means (14) for measuring the passage of time; h) Means that allow to securely attach a fastening element (2) away from the device (1) to the target; i) Means for emitting alarms, alarms which will occur at predetermined times, or when the device 1 has a predetermined inclination, or when the charge of a battery 13 in the device 1 is less than one predetermined value; j) Means of sending and receiving data; 9 k) Means for storage of electric charge;

In order to clarify the intervention of the human component, the individual who will use the portable device (1) to place the drops in his eye will henceforth be referred to as 'User', and what will the system use to verify that the 'User' has correctly placed the drops in the eye will be designated as 'Coordinator User'.

Starting the detailed description of the system by the portable device (1), according to what is visible in the

Error! Reference source not found. this consists of a hollow plastic structure with a capacity to accommodate various components in its empty interior (37) - visible in Figure 3, - namely a Printed Circuit Board (PCB) - which for the sake of simplicity of the description of the invention is not represented by a plurality of sensors and circuits, which will be described in more detail below. It will further be provided with means for coupling a container 33 for dispensing fluid-containing fluids which will preferably be dispensed in the form of droplets, means which preferably take the form of a cavity 32 in the structure of the device 1. The device 1 is also provided with means to be coupled to an element (2) whose function is to fix the position of the target relative to the device, and which is shown in detail in Figure 2, means which consist of two cavities located at the top of the device, as is shown in Figures 1, 4 and 5. Figure 2 shows the preferred configuration for the target distance fixing member (2). Therein, the engaging bolts 24 are secured to the holes 23 of the device 1, and the distance from the target to the device being determined by the length of the rods 25 added to the height of the contact ring 26 the target. Preferably, the contact region of the target ring (26) will be devoid of right angles so as not to damage the target or its periphery.

With regard to the structure of the support (2) to maximize the focus, the dimension of the rods (25), as well as the angles which make the ring (26) and the fixing stud bolts (24) can be variable, provided that the point (2) is aligned or approximately aligned with the optical axis of the chamber (6) such that the entire target is visible, and that the end (4) is vertically aligned and upwardly from the expected position to the target. The occurrence of such vertical alignment depends on the angle of inclination of the device, the angle hereinafter referred to as " optimal angle of use ". Figure 3 shows a section of the device 1, wherein the image acquisition means (6) and the optical focusing means (3) for the scene are visible, these being fixed to the structure of the device (1) preferably through notches in the structure of this, as usually used by those who master the state of the art.

Also shown is the positioning of the orifice 31 in which it will be traversed by the stem 27, wherein said orifice is positioned so that when the fluid dispensing container 33 is properly placed in the cavity 32, the lever rod (28) contacts said container to dispense fluids preferably at a point in the intermediate height of its body. Figure 6 shows the front view of the device (1), in which the preferred position, shape and relative dimension for the buttons (10 and 11) are visible, for the holes (35) associated with the warning means (18 and 19 ), and the holes (36) associated with the sound paging means (20). Also visible is the axis 29 of the lever 27, which axis enables the said lever 27 to be coupled to the device 1 through the mechanical engagement in the structures 30. Figure 7 is the conceptual representation of the fundamental elements of the device. In this, an image acquisition component (6), consisting of a CCD or CMOS camera, is provided with the capacity to acquire a minimum of 30 frames per second, preferably with a minimum resolution of 640 columns per 480 lines of pixels.

The characteristics of the cavity 32 controlling the position of the end 4 of the fluid dispensing container 33 are such that the images acquired by the image acquisition component 6 from a non-static target that is is located at a distance defined by the length of the securing member (2) from the position of the target to enable the end of the fluid dispenser (4) to be viewed.

The images collected by the image acquisition component 6 are stored with reference to the time instant they were acquired in a non-volatile memory 9, preferably an EEPROM, which process is controlled by a controller circuit 12, , preferably consisting of one or more microcontrollers. The light source 5 which illuminates the target and surrounding areas is preferably a Light Emitting Diode (LED), and preferably has its activation synchronized with the activation of the acquisition of images of the camera (6), and its deactivation also synchronized with switch off the shooting mode of the same camera. 13

Preferably, the data from the image acquisition component (6) is sent to a volatile memory (7), and then compressed by a compressor (8), which preferably operates in real time and implements JPEG or MPEG compression, being that the synchronization of functions and data flows are also controlled by the controller (12).

In order to interact with the user, the device is provided with sound emitters (20) preferably consisting of a loudspeaker, luminance emitters (18 and 19), which are preferably preferably colored LEDs, and finally means for enabling the user to interact with the device, said means preferably consisting of two buttons (10 and 11). Button 11 signals the controller 12 to toggle between two system configurations, hereinafter referred to as the ON state and the OFF state (hereinafter referred to as OFF). In the OFF state, the device only actively controls the system date and time, in order to evaluate the criteria for the timed alarms, and to emit them, and for power saving reasons, the supply of non-vital sensors (such as be the accelerometer (15), the chamber (6), and the pressure sensor (16).

In state ΟΝ, all the circuits and sensors are fed, and the controller (12) actively evaluates the slope of the device, emitting various alarms when the angle of inclination of the device is at several distances from the above-mentioned optimum inclination angle, said alarms are audible warnings issued through the sound and / or visual emitter emitted through the emitter (18).

When in this state the lever 27 is depressed and there is a container for dispensing fluids 33 into the cavity therefor the rod 28 presses the bottle causing an increase in the internal pressure thereof and consequent fluid outflow. This pressure increase in the structure of the container for dispensing fluids is detected by the piezoelectric sensor 16, which preferably consists of a piezoelectric crystal, and which is preferably embedded in the side of the cavity 32, as is visible in the exemplary illustration of figure 3.

In order to carry out the aforesaid inclination evaluation, the device is also provided with means (15) preferably constituted by a 3-axis accelerometer.

Another element of this device is a clock (14) for controlling time instants, which is preferably constituted by a quartz crystal, and the association of this clock (14) to the Controller (12) allows to permanently determine the date and time of the system.

In addition, and according to information stored in the non-volatile memory 9, the controller 12 will emit alarms at certain time instants, which alarms will preferably be emitted by the loudspeaker 20 and the visual indicators 18, which alarms will be temporarily silenced by the activation of the button (10), and silenced permanently by activating the ON state and executing a fluid application.

Finally, the clock 14 will be used by the controller 12 to generate a date signature in which data from the camera 6 is stored in the non-volatile memory 9. The beginning of the film recording is synchronized with the detection of activation of the lever (27) by the pressure sensor (16) while the device is ON, and preferably has a fixed duration, preferably of 8 seconds.

All of these elements are powered by a battery 13, and although no figure illustrates the connections - so as to avoid confusion in presenting the idea of the invention - they are implemented in a manner common to the state of the art. The battery (13) is preferably a rechargeable battery, and for this purpose there is a connection port (21) for a power cable. The device contains a circuit 22 for analyzing the charge level of the battery and preferably communicates this value to the controller 12. This evaluates the times when the charge level in the battery 13 is less than a predetermined value, preferably 25% of the maximum capacity thereof, and the controller 12 uses the warning light 19 to visually signal the user, preferably by means of a permanent or intermittent warning light and uses the audible warning 20 to sonically signal the user with one or more short tones using the clock information 14 to coordinate the repetition thereof over a predetermined time interval , preferably 20 minute intervals. The device of Figure 1 is provided with means and circuits (17) allowing the transmission of data between the non-volatile memory (9) and another computational medium (40), wherein preferably this transmission is performed wirelessly and preferably using UMTS technology and Bluetooth. Figure 8 shows the device (1), but in an alternative configuration, in which advantage is taken of the fact that the mobile phones or other currently commercially available devices already have many of the elements 17 necessary for the operation of the invention, such as to be provided with a camera CMOS (6) is provided with an LED (5) for illumination of the recording scene, is provided with a volatile memory (7), is provided with a permanent memory equivalent to the non-volatile memory (9), is provided with a video compressor for the MP4 format equivalent to the Data Compressor (8), is provided with several buttons for interacting with the user like the buttons (10 and 11), is provided with a loudspeaker (20), is provided with a clock (14) is provided with a 3-axis accelerometer (15), is provided with a battery (13), is provided with means (22) for evaluating the battery charge, is provided with means for transmitting visual information to the ut (18) and (19), is provided with an input (21) for recharging the battery, is provided with means for transmitting and receiving data by means of various protocols similar to the data transmission means and circuits ( 17), means which implement communications via bluetooth, GPRS, UMTS, GSM, wi-fi, infra-red and mini-USB, and finally be provided with means to control all these processes in the same way as the controller 12.

In this configuration, the missing elements are essentially mechanical and according to the illustrations provided in Figures 8 and 9, it is relatively simple for one skilled in the art to create an element attachable to a mobile phone. 18

This alternative configuration includes a mobile software component that allows the system not to lose features, and is a trivial software for those who master the state of the art and who is equipped with adequate routines to emit audible and visual alarms on certain dates, silence alarms through the use of buttons, activate an application that actively measures the inclination of the device, emits alarms for certain tilt values, and waits for the use of a button to start recording a predetermined sequence of images. Upon completion of recording, the resulting file is automatically processed to evaluate the success of the application of the fluid droplet, and the video file and the image are sent to a personal computer (40), and are presented to the User-Coordinator. Figure 10 illustrates the device described in this patent and some of the possible variations of the characteristics thereof with respect to the angle between the optical axis 38 of the chamber and the gravitational force axis 39 defining the direction of movement of the fluid as it abandons the container (33) to dispense fluids through its outlet tip (4). The fundamental feature of the system is the existence of a chamber 6 whose optical axis 38 points to the center of the expected location of the target, which position is defined by the support 2, and wherein the gravitational axis 39, which defines the path of the drop and the intersection at that point. Figure 10 shows small variations in the device and support assembly, namely at the position and absolute alignment level of the camera (6) and lens (3), position and characteristics of the support (2), the difference between them being related to the angle of inclination of the head necessary for the user to properly administer the drops. These small variations also affect the value of the optimal angle of incline that will trigger the alarm, but the calculation of this is a trivial trigonometric task. The system described here is endowed with the necessary hardware and software to process the acquired images in order to identify the characteristics of the target, more specifically the identification of the eye visible in the film using the patterns present in the iris. It is also endowed with the necessary hardware and software to the segmentation of the gout at every moment, as well as the evaluation of the position of the eyelids. By analyzing the evolution of the drop's position, it is possible to identify the moment when it came into contact with the eye thanks to the sudden decrease in the velocity of the eye. These two parameters are what allows to evaluate the success of the application of the drop to an eye, thus fulfilling the industrial application of this system.

These hardware and software are located in the portable device (1) and / or integrated in the software that the 20

User-Coordinator will use in the remote computational means (40). The use of the system will preferably start with the configuration of the system and device (1), which configuration will preferably be performed by the User-Coordinator. The preferred system configuration process is illustrated in Figure 11. System configuration by " User-Coordinator " is initiated by the activation of its computer (40) and the device (1). After starting the software application on your computer, the registration of the desired patient is selected - or, if it is a new one, your usual personal data (name, age, address, sex, contact, pathologies, prescriptions) will be added plus one image of each eye.

Since after the application of a drop with the device 1, the video / image sequences acquired and stored in the non-volatile memory 9 is transmitted to the Personal Computer 40 via the means and circuits 17 ) in a format customary to the currently existing communication protocols, and that in case the processing of these images is performed in the device (1), the result is also transmitted to the Personal Computer (40), as well as the time information, success or failure of the application of the drop, and the original video and are stored in a database for the effect, where they are available for visual consultation by the User-Coordinator. Although not shown, the preferred view is a regular hourly grid, listing the days in the columns and the hours on the rows, and wherein for each applied drop is represented by a small icon at the appropriate location, and wherein the color of said icon identifies the success of the application, preferably using the green color to define the success and the color red to define the failure.

Legend of the elements of the figures

Element 1 - Device

Element 2 - Support to fix target distance to device

Element 3 - Lens to maximize focus between target and device

Element 4 - Dropper bottle outlet Element 5 - Scene illumination LED Element 6 - Camera

Element 7 - Volatile Memory (RAM)

Element 8 - Real-time data compressor

Element 9 - Permanent (ROM) - Non-volatile ROM, PROM, EEPROM, FLASH, etc.

Element 10 - Silence Button Element 11 - Application Button ON / OFF Element 12 - PIC Controller Element 13 - Battery Element 14 - Clock

Element 15 - Accelerometer 22

Element 16 - Piezoelectric Sensor Element 17 - Data Transmission Element 18 - Warning Light - Alarm LED Element 19 - Warning Light - LED Battery Element 20 - Beep - Loudspeaker

Element 21 - Input for recharging the battery (in case of being rechargeable)

Item 22 - Battery Charge Control Circuit .a Element 23 - Support Attachment Hole Item 24 - Support Snap Bolt in the Bottle Item 25 - Supporting Rod Item 26 - Eye Contact Ellipse Item 27 - Lever Element 28 - Lever pressure point Element 29 - Lever axis Element 30 - Lever shaft fittings Element 31 - Lever pressure hole Element 32 - Bottle cavity Element 33 - Bottle Element 34 - Droplet body Element 35 - Holes for LED placement Element 36 - Front speaker holes Element 37 - Space used for placement of electrical components

Element 38 - camera's optical axis

Element 39 - Gravity Axis (drop path)

Element 40 - Personal Computer

Lisbon, August 6, 2008

Claims (22)

Method for monitoring the success of applying a fluid dispensed by a fluid dispensing container (33) inserted into a device (1), to a target, characterized by comprising the following steps: a) Detection of the inclination of the device (1); b) Issuing an alarm when the inclination of the device (1) reaches a certain value; c) detecting a pressure increase in the container (33) for dispensing fluids; d) Verification of the simultaneous occurrence of the tilt alarm and the increase of pressure in the vessel to dispense fluids; e) Synchronization of the beginning of the acquisition of images with the occurrence of the state described in d); f) Electronic capture of a plurality of images of the act of administration of the substance, in which the images correspond to distinct and sequential instants; g) Analysis of the collected images to determine the state of the target; h) Analysis of the images to identify the target; i) Analysis of the images to determine the location of the drop at each moment; j) Relationship of the analyzes of g), h) and i) to determine the success of the application of gout; k) Exposure of results. 2 A method for carrying out the process according to claim 1, characterized in that it is constituted by a device (1) which is provided with: a) Means for holding a container (33) for dispensing fluids; b) an element (2) for fixing the position between the target and the device of the (1); c) Means of acquiring images; d) Means (9) for permanently storing digital data consisting of a ROM; e) A circuit (8) for compressing data from the camera; f) an electric sensor for evaluating the inclination of the device (1); g) Means (14) for measuring the passage of time; h) Means that allow to securely attach a fastening element (2) away from the device (1) to the target; i) Means for emitting alarms, alarms which will occur at predetermined times, or when the device 1 has a predetermined inclination, or when the charge of a battery 13 in the device 1 is less than one predetermined value; j) Means of sending and receiving data; k) Means for storage of electric charge. System according to claim 2, characterized in that said device (1) is portable. 3 A system according to claim 2, characterized in that said image acquisition means is a CCD or CMOS camera (6). A system according to claim 4, characterized in that said chamber (6) has the capacity to collect a minimum of 30 frames per second. A system according to claim 4, characterized in that said chamber (6) has a minimum resolution of 640 lines per 480 columns. A system according to claim 2, characterized in that said electric sensor for evaluating the inclination of the device (1) is an accelerometer (15). System according to Claim 2, characterized in that said means for emitting alarms are luminous (18) and audible (20) alarms. A system according to claim 2, characterized in that said device (1) further comprises a cavity (32) in its upper part, which cavity is characterized by a homogeneity of the shape of its cross-section throughout its entire length depth, and in which the container (33) is engaged to dispense fluids. A system according to claim 2, characterized in that said device (1) contains video recording start synchronization means (4) with the start of the droplet application. A system according to claim 10, characterized in that the synchronizing means consist of a piezoelectric sensor (16) placed in the device (1) in a manner that allows it to detect the pressure exerted on the container (33) for dispensing fluids . System according to claim 2, characterized in that said data transmitting and receiving means are wireless communication means. A system according to claim 2, characterized in that said electric charge storage means contains additional means for ascertaining the charge level in the battery (13), and issuing alarms (19), both sonic and luminous, when the value below a certain limit. System according to claim 2, characterized in that the position-fixing member between the target and the device (1) does not obstruct the optical path between the target and the image-acquisition camera (6). A system according to claim 2, characterized in that the expected position of the target intersects the optical axis (38) of the chamber (6). 5 A system according to claim 2, characterized in that an optimum angle of use is associated with the position fixing member between the target and the device (1) in which the expected position of the target is vertically aligned with the dispensing end (33) for dispensing fluids, and below this, when the device is inclined according to said angle. System according to claim 2 and 3, characterized in that the functionalities and structure of said device (1) can be obtained by physically coupling a holder to a container (33) for dispensing fluids to a mobile phone equipped with a camera the characteristics specified in claims 4, 5 and 6 and provided with an accelerometer (15), and by means of a software application to be executed in said mobile telephone. The system of claim 1, wherein the target is an eye and identification thereof is performed using the iris standards. System according to claim 1, characterized in that the target is an eye and the condition of the eye is determined using the maximum distance between the position of the upper eyelid and the position of the lower eyelid. 6 A system according to claim 1, characterized in that the user of the device is immediately advised of the success of the application of the drop. A system according to claim 1, characterized in that the step of identifying the target is a necessary condition to enable the recording of images to start. 22. System according to claim 1, characterized by the existence of the initial transmission step of the PC (40:) to the iris reference image device, and the dates and times of the alarms. Lisbon, August 6, 2008