PT103510B - Utilização da fasciolina (fh8) e/ou de seus derivados na detecção de hospedeiros infectados por fasciola hepática por intradermoreacção - Google Patents

Utilização da fasciolina (fh8) e/ou de seus derivados na detecção de hospedeiros infectados por fasciola hepática por intradermoreacção

Info

Publication number
PT103510B
PT103510B PT103510A PT10351006A PT103510B PT 103510 B PT103510 B PT 103510B PT 103510 A PT103510 A PT 103510A PT 10351006 A PT10351006 A PT 10351006A PT 103510 B PT103510 B PT 103510B
Authority
PT
Portugal
Prior art keywords
fasciola hepatica
definitive
fasciola
detection
trematoda
Prior art date
Application number
PT103510A
Other languages
English (en)
Other versions
PT103510A (pt
Inventor
Jose Manuel Correia Da Costa
Maria Antonia Pereir Conceicao
Elisabete Marta Pereira Silva
Antonio Manuel Oliveira Castro
Original Assignee
Inst Nac De Saude Dr Ricardo J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nac De Saude Dr Ricardo J filed Critical Inst Nac De Saude Dr Ricardo J
Priority to PT103510A priority Critical patent/PT103510B/pt
Priority to EP07768980A priority patent/EP2067037B1/en
Priority to PCT/PT2007/000027 priority patent/WO2008002166A2/en
Priority to AU2007265810A priority patent/AU2007265810B2/en
Priority to MX2009000187A priority patent/MX2009000187A/es
Priority to ES07768980T priority patent/ES2352988T3/es
Priority to JP2009518027A priority patent/JP2009542637A/ja
Priority to DE602007008266T priority patent/DE602007008266D1/de
Priority to CNA2007800245990A priority patent/CN101535810A/zh
Priority to US12/306,725 priority patent/US8025866B2/en
Priority to AT07768980T priority patent/ATE476660T1/de
Publication of PT103510A publication Critical patent/PT103510A/pt
Publication of PT103510B publication Critical patent/PT103510B/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43526—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
    • G01N2333/43547—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from trematodes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)

Abstract

A FASCIOLOSE É UMA DOENÇA ANTROPOZOONÓTICA CAUSADA PELO TREMATODO FASCIOLA HEPATICA. ESTE VERME É UM PARASITA COMUM DOS RUMINANTES, SOBRETUDO OVINOS, CAPRINOS E BOVINOS, CUJO VERME ADULTO É ENCONTRADO NOS DUCTOS BILIARES DO HOSPEDEIRO DEFINITIVO. A FASCIOLOSE É UMA ZOONOSE PARASITÁRIA QUE ACARRETA GRAVES PERDAS ECONÓMICAS COM IMPACTO NA SAÚDE PÚBLICA. OS DIAGNÓSTICOS A NÍVEL DA FASCIOLOSE SÃO ESSENCIALMENTE SEROLÓGICO E PARASITOLÓGICO PELA IDENTIFICAÇÃO DE OVOS NAS FEZES OU VERMES NO FÍGADO. NÃO ESTÃO DISPONÍVEIS DIAGNÓSTICOS QUE PERMITAM EFECTUAR O DIAGNÓSTICO NO CAMPO DIFICULTANDO O CONTROLE EFECTIVO DA DOENÇA. EFECTUAMOS O ISOLAMENTO DE CLONES DE CDNA CODIFICANDO PARA UM POLIPÉPTÍDO DE 69 AMINOÁCIDOS COM UMA MASSA MOLECULAR CALCULADA DE 8 KDA, O QUAL DESIGNAMOS POR FH8 OU FASCIOLINA (GENBANK NUMBER AE2 13970). RESULTADOS OBTIDOS MOSTRARAM QUE O FH8 TEM CARACTERÍSTICAS DE ALERGÉNIO. ESTES RESULTADOS SERVIRAM DE BASE PARA O DESENVOLVIMENTO DA INVENÇÃO QUE TEM POR OBJECTIVO A DETECÇÃO DE HOSPEDEIROS DEFINITIVOS INFECTADOS PELO VERME F. HEPATICA ATRAVÉS DA APLICAÇÃO IN VIVO DO ANTIGÉNIO FH8 (FASCIOLINA), OU OUTRO ANTIGÉNIO COM SEQUÊNCIA SEMELHANTE, A NÍVEL CUTÂNEO. OUTRO ASPECTO DA INVENÇÃO DIZ RESPEITO Á FORMULAÇÃO DA APLICAÇÃO CUTÂNEA E LEITURAS DA REACÇÃO DECORRENTE NOS OVINOS E BOVINOS. EMBORA AS FORMULAÇÕES DESCRITAS DIGAM RESPEITO A ESSES DOIS TIPOS DE HOSPEDEIRO O MÉTODO IDEALIZADO TEM APLICAÇÃO EM TODOS OS HOSPEDEIROS QUE POSSAM SER POTENCIALMENTE INFECTADOS COM F. HEPATICA. ESTES TESTES TÊM COMO PRINCIPAIS VANTAGENS A POSSIBILIDADE DE PODEREM SER REALIZADOS NO TERRENO, SEREM DE FÁCIL EXECUÇÃO E RAPIDEZ NA OBTENÇÃO DOS RESULTADOS PODENDO APRESENTAR GRANDE UTILIDADE NO CONTROLE DA FASCIOLOSE.
PT103510A 2006-06-27 2006-06-27 Utilização da fasciolina (fh8) e/ou de seus derivados na detecção de hospedeiros infectados por fasciola hepática por intradermoreacção PT103510B (pt)

Priority Applications (11)

Application Number Priority Date Filing Date Title
PT103510A PT103510B (pt) 2006-06-27 2006-06-27 Utilização da fasciolina (fh8) e/ou de seus derivados na detecção de hospedeiros infectados por fasciola hepática por intradermoreacção
EP07768980A EP2067037B1 (en) 2006-06-27 2007-06-27 Diagnosis of fasciolosis by skin test (intradermoreaction) using the antigen fh8 (fasciolin)
PCT/PT2007/000027 WO2008002166A2 (en) 2006-06-27 2007-06-27 Diagnosis of fasciolosis by skin test (intradermoreaction) using the antigen fh8 (fasciolin).
AU2007265810A AU2007265810B2 (en) 2006-06-27 2007-06-27 Diagnosis of fasciolosis by skin test (intradermoreaction) using the antigen Fh8 (fasciolin).
MX2009000187A MX2009000187A (es) 2006-06-27 2007-06-27 Diagnostico de fascioliasis mediante prueba cutanea (intradermorreaccion) utilizando el antigeno fh8 (fasciolina).
ES07768980T ES2352988T3 (es) 2006-06-27 2007-06-27 Diagnóstico de fasciólosis mediante prueba de piel (intradermoreacción) utilizando el antígeno fh8 (fasciolina).
JP2009518027A JP2009542637A (ja) 2006-06-27 2007-06-27 抗原Ｆｈ８（ｆａｓｃｉｏｌｉｎ）を用いた皮膚試験（皮内反応）による肝蛭の診断
DE602007008266T DE602007008266D1 (de) 2006-06-27 2007-06-27 Fasziolosediagnose mittels hauttest (intradermoreaktion) unter verwendung des antigens fh8 (fasciolin)
CNA2007800245990A CN101535810A (zh) 2006-06-27 2007-06-27 使用抗原Fh8（fasciolin）的皮肤试验（皮内反应）判断肝片吸虫病
US12/306,725 US8025866B2 (en) 2006-06-27 2007-06-27 Diagnosis of fasciolosis by skin test (intradermoreaction) using the antigen Fh8 (fasciolin)
AT07768980T ATE476660T1 (de) 2006-06-27 2007-06-27 Fasziolosediagnose mittels hauttest (intradermoreaktion) unter verwendung des antigens fh8 (fasciolin)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT103510A PT103510B (pt) 2006-06-27 2006-06-27 Utilização da fasciolina (fh8) e/ou de seus derivados na detecção de hospedeiros infectados por fasciola hepática por intradermoreacção

Publications (2)

Publication Number Publication Date
PT103510A PT103510A (pt) 2007-12-31
PT103510B true PT103510B (pt) 2009-07-21

Family

ID=38727552

Family Applications (1)

Application Number Title Priority Date Filing Date
PT103510A PT103510B (pt) 2006-06-27 2006-06-27 Utilização da fasciolina (fh8) e/ou de seus derivados na detecção de hospedeiros infectados por fasciola hepática por intradermoreacção

Country Status (11)

Country Link
US (1) US8025866B2 (pt)
EP (1) EP2067037B1 (pt)
JP (1) JP2009542637A (pt)
CN (1) CN101535810A (pt)
AT (1) ATE476660T1 (pt)
AU (1) AU2007265810B2 (pt)
DE (1) DE602007008266D1 (pt)
ES (1) ES2352988T3 (pt)
MX (1) MX2009000187A (pt)
PT (1) PT103510B (pt)
WO (1) WO2008002166A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT104331A (pt) * 2009-01-13 2010-07-13 Escola Superior Agrária De Coi Protenas de fus†o, processo para a sua preparaã†o e sua utilizaã†o em sistemas de express†o de protenas recombinantes
JP5832445B2 (ja) * 2009-12-10 2015-12-16 エスコラ スペリオール アグラリア デ コインブラＥｓｃｏｌａ Ｓｕｐｅｒｉｏｒ Ａｇｒａｒｉａ Ｄｅ Ｃｏｉｍｂｒａ 免疫原と、その調製方法及びポリクローナル抗体産生のシステムでの使用
WO2011095181A1 (en) 2010-02-04 2011-08-11 Felici Esteve, Juan Francisco Electrical appliance producing hot water
CN101962679A (zh) * 2010-09-29 2011-02-02 中国疾病预防控制中心寄生虫病预防控制所 一种采用pcr特异检测片形吸虫的试剂盒
CN108101974B (zh) * 2017-12-14 2020-05-05 石河子大学 肝片吸虫多表位融合诊断抗原及其应用和制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3990730B2 (ja) * 1995-12-12 2007-10-17 タカラバイオ株式会社 マラセチア由来の抗原性蛋白質

Also Published As

Publication number Publication date
EP2067037B1 (en) 2010-08-04
JP2009542637A (ja) 2009-12-03
AU2007265810A1 (en) 2008-01-03
WO2008002166A3 (en) 2008-02-28
EP2067037A2 (en) 2009-06-10
PT103510A (pt) 2007-12-31
ES2352988T3 (es) 2011-02-24
WO2008002166A2 (en) 2008-01-03
US8025866B2 (en) 2011-09-27
US20100151482A1 (en) 2010-06-17
ATE476660T1 (de) 2010-08-15
MX2009000187A (es) 2009-05-21
CN101535810A (zh) 2009-09-16
DE602007008266D1 (de) 2010-09-16
AU2007265810B2 (en) 2012-05-03

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