PT102293A - Improved method for preparation of cefixime trihydrate - Google Patents

Improved method for preparation of cefixime trihydrate Download PDF

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Publication number
PT102293A
PT102293A PT102293A PT10229399A PT102293A PT 102293 A PT102293 A PT 102293A PT 102293 A PT102293 A PT 102293A PT 10229399 A PT10229399 A PT 10229399A PT 102293 A PT102293 A PT 102293A
Authority
PT
Portugal
Prior art keywords
protected
yields
amino
cefixime
preparation
Prior art date
Application number
PT102293A
Other languages
Portuguese (pt)
Other versions
PT102293B (en
Inventor
Anil Kumar Sharma
Baldev Raj
Kumar Sethi Dr Madhuresh
Debashis Das
Original Assignee
J K Drugs & Pharmaceuticals Lt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J K Drugs & Pharmaceuticals Lt filed Critical J K Drugs & Pharmaceuticals Lt
Publication of PT102293A publication Critical patent/PT102293A/en
Publication of PT102293B publication Critical patent/PT102293B/en

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Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)

Abstract

The invention provides an improved method for the preparation of cefixime trihydrate of formula I: <IMAGE>, Formula I The 7(amino-substituted) cephalosporanic acid undergoes hydrolysis with alkaline carbonate followed by acylation at the 7-amino group with organic acid chloride and esterification at the 4-carboxy group to yield the protected 4-hydroxymethylcefeme, which after bromination with PBr3 and Wittig reaction with triphenylphosphine/aq. formaldehyde yields the protected 3-vinyl cefeme. The 7- phenylacetyl side chain is then cloven using a complex of triphenylphosphide/chlorine/pyridine/IBA to yield the 7- amino compound which, after binding to 4-chlor-2- methoxycarbonylmethoxy-imino-3-oxobutyric acid and ring formation with thiourea, yields the protected cefixime. Removal of the protecting groups yields the above- entitled compound.
PT102293A 1999-01-29 1999-04-26 IMPROVED PROCESS FOR THE PREPARATION OF Cefixime TRI-HYDRATE PT102293B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN75BO1999 IN185070B (en) 1999-01-29 1999-01-29

Publications (2)

Publication Number Publication Date
PT102293A true PT102293A (en) 2000-02-29
PT102293B PT102293B (en) 2001-05-31

Family

ID=11077351

Family Applications (1)

Application Number Title Priority Date Filing Date
PT102293A PT102293B (en) 1999-01-29 1999-04-26 IMPROVED PROCESS FOR THE PREPARATION OF Cefixime TRI-HYDRATE

Country Status (2)

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IN (1) IN185070B (en)
PT (1) PT102293B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115710282A (en) * 2022-11-23 2023-02-24 湖北凌晟药业股份有限公司 Cefixime methyl ester impurity and preparation method thereof

Also Published As

Publication number Publication date
IN185070B (en) 2000-11-04
PT102293B (en) 2001-05-31

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Effective date: 19990630

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Effective date: 20010223

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Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20021031