PT1020474E - OLIGOSACARIDARY DERIVATIVES AND PROCESS FOR THEIR OBTAINATION - Google Patents

OLIGOSACARIDARY DERIVATIVES AND PROCESS FOR THEIR OBTAINATION

Info

Publication number
PT1020474E
PT1020474E PT98938923T PT98938923T PT1020474E PT 1020474 E PT1020474 E PT 1020474E PT 98938923 T PT98938923 T PT 98938923T PT 98938923 T PT98938923 T PT 98938923T PT 1020474 E PT1020474 E PT 1020474E
Authority
PT
Portugal
Prior art keywords
group
oligosacaridary
obtaination
derivatives
polysaccharide
Prior art date
Application number
PT98938923T
Other languages
Portuguese (pt)
Inventor
Masato Nagaoka
Hideyuki Shibata
Itsuko Kimura
Shusuke Hashimoto
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Publication of PT1020474E publication Critical patent/PT1020474E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

An oligosaccharide derivative, at higher homogeneity than fucose polysaccharide and rhamnose polysaccharide and with greater antiulcer effects, which is represented by the following general formula: Y-OCH (CH2NHR)2 wherein, Y represents an oligofucose or oligorhamnose at a polymerization number of 2 to 20, where the hydroxyl groups may or may not be partially modified in the form of sulfate ester, and R represents phenyl group, a higher alkylphenyl group, a higher alkyl group or -(CH2)n-NHX wherein n is an integer of 1 to 10 and X represents a higher alkanoyl group or an alkylamino group. <IMAGE>
PT98938923T 1997-08-22 1998-08-21 OLIGOSACARIDARY DERIVATIVES AND PROCESS FOR THEIR OBTAINATION PT1020474E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9240298A JPH1160590A (en) 1997-08-22 1997-08-22 Oligofucose derivative or oligorhamnose derivative and its production

Publications (1)

Publication Number Publication Date
PT1020474E true PT1020474E (en) 2003-09-30

Family

ID=17057396

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98938923T PT1020474E (en) 1997-08-22 1998-08-21 OLIGOSACARIDARY DERIVATIVES AND PROCESS FOR THEIR OBTAINATION

Country Status (13)

Country Link
US (2) US6518249B1 (en)
EP (1) EP1020474B1 (en)
JP (1) JPH1160590A (en)
KR (1) KR20010040236A (en)
CN (1) CN1275129A (en)
AT (1) ATE238327T1 (en)
AU (1) AU728628B2 (en)
CA (1) CA2301893A1 (en)
DE (1) DE69813855T2 (en)
DK (1) DK1020474T3 (en)
ES (1) ES2197492T3 (en)
PT (1) PT1020474E (en)
WO (1) WO1999010360A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001478A1 (en) * 1997-07-03 1999-01-14 Masakuni Tako Acetylfucoidan prepared from okinawa nemacystis decipiens and process for preparing the same
JP3982916B2 (en) * 1998-07-31 2007-09-26 タカラバイオ株式会社 Anti-Helicobacter pylori
JP3958884B2 (en) 1998-09-11 2007-08-15 株式会社林原生物化学研究所 Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and method for producing saccharide using the enzyme
DE69926770T2 (en) 1998-10-05 2006-06-29 Kabushiki Kaisha Yakult Honsha ANTIBACTERIAL AGENTS AND METHOD OF MANUFACTURE THEREOF
AU6593400A (en) * 1999-08-20 2001-03-19 Takara Shuzo Co., Ltd. Remedies
JP3817114B2 (en) * 2000-05-26 2006-08-30 株式会社ヤクルト本社 Antioxidant and external preparation for skin containing the same
DE60202427T2 (en) * 2001-10-24 2005-12-29 Takara Bio Inc., Otsu Sulfated fucan oligosaccharide
DE102004047722B4 (en) * 2004-09-30 2007-12-20 Universität Rostock Process for isolating and separating carbohydrates from aqueous media and use of ionic liquids for the extraction of carbohydrates
JP5014018B2 (en) * 2006-10-18 2012-08-29 旭化成ケミカルズ株式会社 Helicobacter pylori suppressor or bacteriostatic agent
PT104888B (en) * 2009-12-15 2020-09-10 73100 - Setenta E Três Mil E Cem, Lda BACTERIAL BIOPOLYMER CONTAINING FUCOSE
EP2692740A1 (en) * 2012-07-30 2014-02-05 Le Centre National De La Recherche Scientifique Glycan compositions, processes for preparing the same and their uses as a drug
CN109045064B (en) * 2018-08-02 2020-03-31 山东大学 Preparation method and application of fucoidin and curcumin solid dispersion

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06247861A (en) 1993-02-26 1994-09-06 Yakult Honsha Co Ltd Antiulcer agent and its production
DK76193D0 (en) * 1993-06-25 1993-06-25 Astra Ab CARBOHYDRATE DERIVATIVES
JP3403496B2 (en) 1993-09-24 2003-05-06 株式会社ヤクルト本社 Anti-ulcer agent and Helicobacter pylori colonization inhibitor
US5891862A (en) * 1996-03-15 1999-04-06 Geltex Pharmaceuticals, Inc. Polyvalent polymers for the treatment of rotavirus infection

Also Published As

Publication number Publication date
DE69813855D1 (en) 2003-05-28
US6518249B1 (en) 2003-02-11
DK1020474T3 (en) 2003-08-11
CA2301893A1 (en) 1999-03-04
KR20010040236A (en) 2001-05-15
EP1020474A1 (en) 2000-07-19
CN1275129A (en) 2000-11-29
US6645940B2 (en) 2003-11-11
WO1999010360A1 (en) 1999-03-04
EP1020474A4 (en) 2001-10-17
ATE238327T1 (en) 2003-05-15
JPH1160590A (en) 1999-03-02
ES2197492T3 (en) 2004-01-01
US20030109489A1 (en) 2003-06-12
AU8748298A (en) 1999-03-16
DE69813855T2 (en) 2004-03-11
AU728628B2 (en) 2001-01-11
EP1020474B1 (en) 2003-04-23

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