PL450192A1 - Sposób analizy próbki pod kątem wykrywania raka jajnika z wykorzystaniem modelu uczenia maszynowego - Google Patents

Sposób analizy próbki pod kątem wykrywania raka jajnika z wykorzystaniem modelu uczenia maszynowego

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Publication number
PL450192A1
PL450192A1 PL450192A PL45019224A PL450192A1 PL 450192 A1 PL450192 A1 PL 450192A1 PL 450192 A PL450192 A PL 450192A PL 45019224 A PL45019224 A PL 45019224A PL 450192 A1 PL450192 A1 PL 450192A1
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PL
Poland
Prior art keywords
sample
ovarian cancer
analyzing
machine learning
learning model
Prior art date
Application number
PL450192A
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English (en)
Inventor
Maksym JOPEK
Anna Supernat
Michał Sieczczyński
Krzysztof Pastuszak
Anna Żaczek
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Gdański Uniwersytet Medyczny
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Publication date
Application filed by Gdański Uniwersytet Medyczny filed Critical Gdański Uniwersytet Medyczny
Priority to PL450192A priority Critical patent/PL450192A1/pl
Priority to EP25207943.9A priority patent/EP4738369A1/en
Publication of PL450192A1 publication Critical patent/PL450192A1/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Data Mining & Analysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Bioethics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Microbiology (AREA)
  • Evolutionary Computation (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Biomedical Technology (AREA)
  • Primary Health Care (AREA)
  • Signal Processing (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób analizy próbki materiału biologicznego pod kątem wykrywania raka jajnika, polegający na izolacji RNA z płytek krwi, przygotowaniu bibliotek cDNA, fragmentowaniu, indeksowaniu molekularnie barkodami Illumina, sekwencjonowaniu i obróbce bioinformatycznej, w którym zsekwencjonowane biblioteki cDNA po obróbce bioinformatycznej mapuje się do ludzkiego genomu referencyjnego (hg19), a następnie wybiera się próbki zsekwencjonowanego cDNA o liczbie odczytów większej niż 100 000 na próbkę, dane normalizuje się za pomocą transformacji stabilizującej wariancję i trenowanie modelu zachodzi na danych treningowych bazując na ocenie jakości klasyfikacji za pomocą zbioru walidacyjnego, w ostatnim etapie ocenia się próbkę przez uzyskany algorytm, który dokonuje oceny próbki jako „rak jajnika” lub „próbka od osoby zdrowej”.
PL450192A 2024-10-31 2024-10-31 Sposób analizy próbki pod kątem wykrywania raka jajnika z wykorzystaniem modelu uczenia maszynowego PL450192A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL450192A PL450192A1 (pl) 2024-10-31 2024-10-31 Sposób analizy próbki pod kątem wykrywania raka jajnika z wykorzystaniem modelu uczenia maszynowego
EP25207943.9A EP4738369A1 (en) 2024-10-31 2025-10-10 A method of analyzing a sample for ovarian cancer detection using a machine learning model

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL450192A PL450192A1 (pl) 2024-10-31 2024-10-31 Sposób analizy próbki pod kątem wykrywania raka jajnika z wykorzystaniem modelu uczenia maszynowego

Publications (1)

Publication Number Publication Date
PL450192A1 true PL450192A1 (pl) 2026-05-04

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PL450192A PL450192A1 (pl) 2024-10-31 2024-10-31 Sposób analizy próbki pod kątem wykrywania raka jajnika z wykorzystaniem modelu uczenia maszynowego

Country Status (2)

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EP (1) EP4738369A1 (pl)
PL (1) PL450192A1 (pl)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114634969A (zh) * 2022-02-28 2022-06-17 华中科技大学同济医学院附属同济医院 血小板102基因用于卵巢癌的诊断模型、构建方法及应用
CN115125289A (zh) * 2022-07-22 2022-09-30 华中科技大学同济医学院附属同济医院 一种血小板102基因用于卵巢癌的诊断模型、构建方法及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9984201B2 (en) * 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
WO2019200410A1 (en) * 2018-04-13 2019-10-17 Freenome Holdings, Inc. Machine learning implementation for multi-analyte assay of biological samples

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114634969A (zh) * 2022-02-28 2022-06-17 华中科技大学同济医学院附属同济医院 血小板102基因用于卵巢癌的诊断模型、构建方法及应用
CN115125289A (zh) * 2022-07-22 2022-09-30 华中科技大学同济医学院附属同济医院 一种血小板102基因用于卵巢癌的诊断模型、构建方法及应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CYGERT, S ET AL.: "Cancers 2023, 15, 2336. https://doi.org/10.3390/cancers15082336", PLATELET-BASED LIQUID BIOPSIES THROUGH THE LENS OF MACHINE LEARNING *

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EP4738369A1 (en) 2026-05-06

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