PL449093A1 - Fiber optic sensor for testing for SARS-CoV-2 and method of making the sensor - Google Patents

Fiber optic sensor for testing for SARS-CoV-2 and method of making the sensor

Info

Publication number
PL449093A1
PL449093A1 PL449093A PL44909324A PL449093A1 PL 449093 A1 PL449093 A1 PL 449093A1 PL 449093 A PL449093 A PL 449093A PL 44909324 A PL44909324 A PL 44909324A PL 449093 A1 PL449093 A1 PL 449093A1
Authority
PL
Poland
Prior art keywords
cov
sars
sensor
antibodies
testing
Prior art date
Application number
PL449093A
Other languages
Polish (pl)
Inventor
Kamil Kosiel
Joanna Jankowska-Śliwińska
Anna Szerling
Ryszard Buczyński
Maciej A. Kozubal
Krzysztof Grąbczewski
Piotr Polak
Karina Wojciechowska
Laura Stańco
Marek Ekielski
Michał SZYMAŃSKI
Krzysztof GAJOWNICZEK
Original Assignee
Sieć Badawcza Łukasiewicz - Instytut Mikroelektroniki I Fotoniki
Szkoła Główna Gospodarstwa Wiejskiego w Warszawie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sieć Badawcza Łukasiewicz - Instytut Mikroelektroniki I Fotoniki, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie filed Critical Sieć Badawcza Łukasiewicz - Instytut Mikroelektroniki I Fotoniki
Priority to PL449093A priority Critical patent/PL449093A1/en
Publication of PL449093A1 publication Critical patent/PL449093A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D5/00—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable
    • G01D5/26—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable characterised by optical transfer means, i.e. using infrared, visible, or ultraviolet light
    • G01D5/32—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable characterised by optical transfer means, i.e. using infrared, visible, or ultraviolet light with attenuation or whole or partial obturation of beams of light
    • G01D5/34—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable characterised by optical transfer means, i.e. using infrared, visible, or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells
    • G01D5/353—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable characterised by optical transfer means, i.e. using infrared, visible, or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells influencing the transmission properties of an optical fibre
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Przedmiotem zgłoszenia jest czujnik światłowodowy do badań na obecność SARS-CoV-2 oraz sposób wykonania tego czujnika. Czujnik światłowodowy do badań na obecność SARS-CoV-2, oparty na rezonansowym efekcie (LMR) oraz sposób wykonania tego czujnika. Obszarze czujnikowym (3) o długości od 5 do 100 mm znajdującym się na odsłoniętym rdzeniu (2) lub na bocznie pocienionym włóknie z pozostawieniem płaszcza resztkowego o grubości do 5 µm lub też na bocznie pocienionym włóknie z całkowicie pocienionym bocznie płaszczem (1) i częściowo do 20% pocienionym bocznie rdzeniem ma powłokę dielektryczną (4) o grubości co najmniej 10 nm. Część rzeczywista współczynnika załamania powłoki ma wartość większą niż wartość współczynnika załamania rdzenia włókna światłowodowego, a część urojona współczynnika załamania ma wartość bliską zeru lecz niezerową. Powłoka dielektryczna pokryta jest warstwą funkcjonalizacji (5) wykonanej metodą silanizacji i posiada unieruchomione na niej receptory (6) analitów pochodzących od SARS-CoV-2, w postaci przeciwciał skierowanych przeciwko jednemu z białek strukturalnych SARS-CoV-2 czyli przeciwciał anti-S albo przeciwciał anti-E albo przeciwciał anti-M albo przeciwciał anti-N.The subject of the application is a fiber optic sensor for testing for the presence of SARS-CoV-2 and a method for making this sensor. A fiber optic sensor for testing for the presence of SARS-CoV-2, based on the light-resonant (LMR) effect, and a method for making this sensor. A sensing area (3) with a length of 5 to 100 mm located on an exposed core (2) or on a laterally thinned fiber leaving a residual cladding with a thickness of up to 5 µm, or on a laterally thinned fiber with a completely laterally thinned cladding (1) and a core partially thinned laterally by up to 20%, has a dielectric coating (4) with a thickness of at least 10 nm. The real part of the refractive index of the coating is greater than the refractive index of the fiber core, and the imaginary part of the refractive index is close to zero but non-zero. The dielectric coating is covered with a functionalization layer (5) made by the silanization method and has receptors (6) of analytes derived from SARS-CoV-2 immobilized on it, in the form of antibodies directed against one of the structural proteins of SARS-CoV-2, i.e. anti-S antibodies or anti-E antibodies or anti-M antibodies or anti-N antibodies.

PL449093A 2024-07-01 2024-07-01 Fiber optic sensor for testing for SARS-CoV-2 and method of making the sensor PL449093A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL449093A PL449093A1 (en) 2024-07-01 2024-07-01 Fiber optic sensor for testing for SARS-CoV-2 and method of making the sensor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL449093A PL449093A1 (en) 2024-07-01 2024-07-01 Fiber optic sensor for testing for SARS-CoV-2 and method of making the sensor

Publications (1)

Publication Number Publication Date
PL449093A1 true PL449093A1 (en) 2026-01-05

Family

ID=98264471

Family Applications (1)

Application Number Title Priority Date Filing Date
PL449093A PL449093A1 (en) 2024-07-01 2024-07-01 Fiber optic sensor for testing for SARS-CoV-2 and method of making the sensor

Country Status (1)

Country Link
PL (1) PL449093A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2363285A1 (en) * 2009-09-07 2011-07-28 Universidad Publica De Navarra Coated fibre optic sensors based on near cutoff lossy mode resonance

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2363285A1 (en) * 2009-09-07 2011-07-28 Universidad Publica De Navarra Coated fibre optic sensors based on near cutoff lossy mode resonance

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHIAVAIOLI, F. ET AL.: "In: Di Francia, G., et al. Sensors and Microsystems. AISEM 2019. Lecture Notes in Electrical Engineering, vol 629. Springer, Cham. https://doi.org/10.1007/978-3-030-37558-4_49", LOSSY MODE RESONANCE ENABLING ULTRA-LOW DETECTION LIMIT FOR FIBRE-OPTIC BIOSENSORS (INVITED) *
DEL VILLAR, I. ET AL.: "(2017) Sensors and Actuators B: Chemical, 240,174-185", OPTICAL SENSORS BASED ON LOSSY MODE RESONANCES *

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