PL449088A1 - 3D polymer gel dosimeters imitating soft tissues, lung tissue and human bone tissue, and a multiphase 3D polymer gel dosimeter for measuring spatial distributions of ionizing radiation doses in these tissues simultaneously - Google Patents

3D polymer gel dosimeters imitating soft tissues, lung tissue and human bone tissue, and a multiphase 3D polymer gel dosimeter for measuring spatial distributions of ionizing radiation doses in these tissues simultaneously

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Publication number
PL449088A1
PL449088A1 PL449088A PL44908824A PL449088A1 PL 449088 A1 PL449088 A1 PL 449088A1 PL 449088 A PL449088 A PL 449088A PL 44908824 A PL44908824 A PL 44908824A PL 449088 A1 PL449088 A1 PL 449088A1
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PL
Poland
Prior art keywords
poly
polymer gel
imitating
bone tissue
dosimeter
Prior art date
Application number
PL449088A
Other languages
Polish (pl)
Inventor
Marek Kozicki
Malwina Jaszczak-Kuligowska
Piotr Maras
Original Assignee
Politechnika Łódzka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Politechnika Łódzka filed Critical Politechnika Łódzka
Priority to PL449088A priority Critical patent/PL449088A1/en
Publication of PL449088A1 publication Critical patent/PL449088A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/02—Dosimeters
    • G01T1/04—Chemical dosimeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measurement Of Radiation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest dozymetr żelowy 3D imitujący tkanki miękkie, zawierający matrycę z triblokowego kopolimeru poli(tlenek etylenu)-poli(tlenek propylenu)-poli(tlenek etylenu) z rozpuszczonymi w niej monomerami w postaci N,N'-metylenobisakryloamidu oraz akryloamidu jako związkami aktywnymi, odtleniacz w postaci wodnego roztworu chlorku tetrakis(hydroksymetylo)fosfoniowego, a także wodę, ewentualnie zawiera także sól nieorganiczną. Przedmiotem zgłoszenia jest także dozymetr żelowy 3D imitujący tkankę kostną, zawierający matrycę z rozpuszczonymi w niej monomerami w postaci N,N'-metylenobisakryloamidu oraz akryloamidu jako związkami aktywnymi, odtleniacz w postaci 80% wodnego roztworu chlorku tetrakis(hydroksymetylo)fosfoniowego, budulec tkanki kostnej, a także wodę, zawiera matrycę z triblokowego kopolimeru poli(tlenek etylenu)-poli(tlenek propylenu)-poli(tlenek etylenu), jako budulec tkanki kostnej zawiera hydroksyapatyt, nadto zawiera sól nieorganiczną. Zgłoszenie obejmuje też dozymetr żelowy 3D imitujący tkankę płucną, zawierający matrycę z triblokowego kopolimeru poli(tlenek etylenu)-poli(tlenek propylenu)-poli(tlenek etylenu) z rozpuszczonymi w niej monomerami w postaci N,N'-metylenobisakryloamidu oraz akryloamidu, odtleniacz w postaci 80% wodnego roztworu chlorku tetrakis(hydroksymetylo)fosfoniowego, a także wodę, stanowiący strukturę spienioną, zawiera ewentualnie także sól nieorganiczną. Dozymetr stanowi strukturę spienioną od 1,1 do 10-krotnego zwiększenia objętości. Przedmiotem zgłoszenia jest ponadto wielofazowy polimerowy dozymetr żelowy 3D do pomiarów przestrzennych rozkładów dawek promieniowania jonizującego jednocześnie w tkankach miękkich, tkance płucnej i tkance kostnej człowieka, zawiera warstwy polimerowego dozymetru żelowego 3D imitującego tkanki miękkie określonego powyżej, warstwę polimerowego dozymetru żelowego 3D imitującego tkankę kostną określonego powyżej oraz warstwę polimerowego dozymetru żelowego 3D imitującego tkankę płucną określonego powyżej, ułożone jedna na drugiej w kolejności imitującej rozmieszczenie tych tkanek w organizmie ludzkim.The subject of the application is a 3D gel dosimeter imitating soft tissues, containing a matrix of a triblock copolymer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) with monomers dissolved therein in the form of N,N'-methylenebisacrylamide and acrylamide as active compounds, a deoxidizer in the form of an aqueous solution of tetrakis(hydroxymethyl)phosphonium chloride, and water, and optionally also containing an inorganic salt. The subject of the application is also a 3D gel dosimeter imitating bone tissue, containing a matrix with monomers dissolved therein in the form of N,N'-methylenebisacrylamide and acrylamide as active compounds, a deoxidizer in the form of an 80% aqueous solution of tetrakis(hydroxymethyl)phosphonium chloride, a building block of bone tissue, and water, containing a matrix made of a triblock copolymer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), containing hydroxyapatite as a building block of bone tissue, and further containing an inorganic salt. The application also covers a 3D gel dosimeter simulating lung tissue, comprising a matrix of a triblock copolymer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) with N,N'-methylenebisacrylamide and acrylamide monomers dissolved therein, a deoxidizer in the form of an 80% aqueous solution of tetrakis(hydroxymethyl)phosphonium chloride, and water, constituting a foamed structure, optionally also containing an inorganic salt. The dosimeter comprises a foamed structure with a 1.1- to 10-fold increase in volume. The subject of the application is also a multiphase 3D polymer gel dosimeter for measuring spatial distributions of ionizing radiation doses simultaneously in soft tissues, lung tissue and bone tissue of a human, comprising layers of a 3D polymer gel dosimeter imitating soft tissues as defined above, a layer of a 3D polymer gel dosimeter imitating bone tissue as defined above and a layer of a 3D polymer gel dosimeter imitating lung tissue as defined above, arranged one on top of the other in an order imitating the distribution of these tissues in the human body.

PL449088A 2024-07-01 2024-07-01 3D polymer gel dosimeters imitating soft tissues, lung tissue and human bone tissue, and a multiphase 3D polymer gel dosimeter for measuring spatial distributions of ionizing radiation doses in these tissues simultaneously PL449088A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL449088A PL449088A1 (en) 2024-07-01 2024-07-01 3D polymer gel dosimeters imitating soft tissues, lung tissue and human bone tissue, and a multiphase 3D polymer gel dosimeter for measuring spatial distributions of ionizing radiation doses in these tissues simultaneously

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL449088A PL449088A1 (en) 2024-07-01 2024-07-01 3D polymer gel dosimeters imitating soft tissues, lung tissue and human bone tissue, and a multiphase 3D polymer gel dosimeter for measuring spatial distributions of ionizing radiation doses in these tissues simultaneously

Publications (1)

Publication Number Publication Date
PL449088A1 true PL449088A1 (en) 2026-01-05

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PL449088A PL449088A1 (en) 2024-07-01 2024-07-01 3D polymer gel dosimeters imitating soft tissues, lung tissue and human bone tissue, and a multiphase 3D polymer gel dosimeter for measuring spatial distributions of ionizing radiation doses in these tissues simultaneously

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PL (1) PL449088A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104258505A (en) * 2014-09-19 2015-01-07 西安交通大学医学院第一附属医院 Anthropomorphic phantom for tumor radiotherapy dosage individualized verification and building method and application thereof
EP3059612A1 (en) * 2015-02-23 2016-08-24 Universita degli Studi della Calabria 3d dosimeter and dosimetric method using 3d dosimeter
US20170248708A1 (en) * 2014-06-25 2017-08-31 Commissariat A L'energie Atomique Et Aux Energies Alternatives Method of producing a radiometric physical phantom of a biological organism and physical phantom produced by this method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170248708A1 (en) * 2014-06-25 2017-08-31 Commissariat A L'energie Atomique Et Aux Energies Alternatives Method of producing a radiometric physical phantom of a biological organism and physical phantom produced by this method
CN104258505A (en) * 2014-09-19 2015-01-07 西安交通大学医学院第一附属医院 Anthropomorphic phantom for tumor radiotherapy dosage individualized verification and building method and application thereof
EP3059612A1 (en) * 2015-02-23 2016-08-24 Universita degli Studi della Calabria 3d dosimeter and dosimetric method using 3d dosimeter

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MALWINA JASZCZAK, RADOSŁAW WACH, PIOTR MARAS, MARIUSZ DUDEK I MAREK KOZICKI: "6 września 2018, 63, 175010", PHYSICS IN MEDICINE & BIOLOGY *

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