PL447483A1 - Method of obtaining bone substitute biomaterial in the form of hybrid granules - Google Patents
Method of obtaining bone substitute biomaterial in the form of hybrid granulesInfo
- Publication number
- PL447483A1 PL447483A1 PL447483A PL44748324A PL447483A1 PL 447483 A1 PL447483 A1 PL 447483A1 PL 447483 A PL447483 A PL 447483A PL 44748324 A PL44748324 A PL 44748324A PL 447483 A1 PL447483 A1 PL 447483A1
- Authority
- PL
- Poland
- Prior art keywords
- granules
- methylcellulose
- temperature
- bone substitute
- solution
- Prior art date
Links
- 239000008187 granular material Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000012620 biological material Substances 0.000 title abstract 2
- 239000000316 bone substitute Substances 0.000 title abstract 2
- 229920000609 methyl cellulose Polymers 0.000 abstract 3
- 239000001923 methylcellulose Substances 0.000 abstract 3
- 239000006087 Silane Coupling Agent Substances 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 230000035800 maturation Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 229910000077 silane Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
Abstract
Zgłoszenie dotyczy sposobu otrzymywania biomateriałów kościozastępczych w postaci hybrydowych granul na bazie hydroksyapatytu i metylocelulozy, powierzchniowo modyfikowanych silanowymi środkami sprzęgającymi. Sposób polega na tym, że do wodnej zawiesiny wodorotlenku wapnia Ca(OH)<sub>2</sub> dodaje się wodną mieszaninę jonów fosforanowych (V), przy czym stosunek molowy wapń : fosfor zawiera się w przedziale od 1,4 do 1,8, oraz wodny roztwór metylocelulozy, w ilości do uzyskania od 1 do 50% mas. metylocelulozy w końcowym produkcie, a pH środowiska utrzymuje się na poziomie 6 - 14, wytrącony osad poddaje się dojrzewaniu, po czym zamraża się na okres co najmniej jednej godziny w temp. od —1°C do -50°C, następnie rozmraża i suszy w temperaturze od 5°C do 80°C i frakcjonuje za pomocą sit, następnie uzyskane granule dodaje się do roztworu silanowego środka sprzęgającego w alkoholu o stężeniu 10 —99,9%, przy czym ilość silanowego środka wynosi od 0,1% do 30% mas., następnie całość miesza się w temperaturze 10 — 50°C i pozostawia w roztworze na czas nie krótszy niż 20 minut, następnie granule suszy się.The application concerns a method of obtaining bone substitute biomaterials in the form of hybrid granules based on hydroxyapatite and methylcellulose, surface modified with silane coupling agents. The method consists in adding an aqueous mixture of phosphate (V) ions to an aqueous suspension of calcium hydroxide Ca(OH)<sub>2</sub>, wherein the molar ratio of calcium:phosphorus is in the range of 1.4 to 1.8, and an aqueous solution of methylcellulose, in an amount to obtain from 1 to 50% by weight. methylcellulose in the final product, and the pH of the environment is maintained at 6-14, the precipitate is subjected to maturation and then frozen for a period of at least one hour at a temperature of -1°C to -50°C, then thawed and dried at a temperature of 5°C to 80°C and fractionated using sieves, then the obtained granules are added to a solution of a silane coupling agent in alcohol with a concentration of 10-99.9%, where the amount of silane agent is from 0.1% to 30% by weight, then the whole is mixed at a temperature of 10-50°C and left in the solution for no less than 20 minutes, then the granules are dried.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL447483A PL447483A1 (en) | 2024-01-09 | 2024-01-09 | Method of obtaining bone substitute biomaterial in the form of hybrid granules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL447483A PL447483A1 (en) | 2024-01-09 | 2024-01-09 | Method of obtaining bone substitute biomaterial in the form of hybrid granules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL447483A1 true PL447483A1 (en) | 2024-07-29 |
Family
ID=91971292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL447483A PL447483A1 (en) | 2024-01-09 | 2024-01-09 | Method of obtaining bone substitute biomaterial in the form of hybrid granules |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL447483A1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL190486B1 (en) * | 1999-03-09 | 2005-12-30 | Akad Gorniczo Hutnicza | Method of obtaining highly reactive calcium phosphate powder |
| PL210026B1 (en) * | 2009-03-17 | 2011-11-30 | Akademia Górniczo Hutnicza Im Stanisława Staszica | Method of manufacturing the high-porous, bioactive calcium phosphate implant material |
-
2024
- 2024-01-09 PL PL447483A patent/PL447483A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL190486B1 (en) * | 1999-03-09 | 2005-12-30 | Akad Gorniczo Hutnicza | Method of obtaining highly reactive calcium phosphate powder |
| PL210026B1 (en) * | 2009-03-17 | 2011-11-30 | Akademia Górniczo Hutnicza Im Stanisława Staszica | Method of manufacturing the high-porous, bioactive calcium phosphate implant material |
Non-Patent Citations (3)
| Title |
|---|
| E. CICHOŃ ET AL, . "DEVELOPMENT OF HIGHLY POROUS CALCIUM PHOSPHATE BONE CEMENTS APPLYING NONIONIC SURFACE ACTIVE AGENTS" , RSC ADV., 2021, 11, 23908–23921 * |
| P.PAŃTAK ET AL., "THE INFLUENCE OF SILANE COUPLING AGENTS ON THE PROPERTIES OF Α-TCP-BASED CERAMIC BONE SUBSTITUTES FOR ORTHOPAEDIC APPLICATIONS" RSC ADV., 2023, 13, 34020–34031, HTTPS://DOI.ORG/10.1039/D3RA06027F * |
| SienceDirect; Sarish Rehman " Synthesis of nano-hydroxyapatite and its rapid mediated surface functionalization by silane coupling agent" , Volume 58, 1 January 2016, Pages 675-681https://www.sciencedirect.com/journal/materials-science-and-engineering-c * |
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