PL447285A1 - Biosensor for mesothelin determination using matrix surface plasmon resonance technique in Imaging version - Google Patents

Biosensor for mesothelin determination using matrix surface plasmon resonance technique in Imaging version

Info

Publication number
PL447285A1
PL447285A1 PL447285A PL44728523A PL447285A1 PL 447285 A1 PL447285 A1 PL 447285A1 PL 447285 A PL447285 A PL 447285A PL 44728523 A PL44728523 A PL 44728523A PL 447285 A1 PL447285 A1 PL 447285A1
Authority
PL
Poland
Prior art keywords
mesothelin
biosensor
plasmon resonance
surface plasmon
determination
Prior art date
Application number
PL447285A
Other languages
Polish (pl)
Inventor
Anna Sankiewicz
Ewa Gorodkiewicz
Original Assignee
Uniwersytet W Białymstoku
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet W Białymstoku filed Critical Uniwersytet W Białymstoku
Priority to PL447285A priority Critical patent/PL447285A1/en
Publication of PL447285A1 publication Critical patent/PL447285A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Przedmiotem zgłoszenia jest biosensor do specyficznego oznaczania mezoteliny w płynach ustrojowych i homogenatach tkankowych techniką matrycowego powierzchniowego rezonansu plazmonów w wersji Imaging, który stanowi płytkę szklaną (1) pokrytą warstwą złota (3) na podłożu tytanu (3) oraz siatkę polimeru (4) tworzącą pęk miejsc aktywnych zawierających warstwę receptorową, którą stanowi królicze monoklonalne przeciwciało specyficzne na mezotelinę (6), zimmobilizowane na powierzchni złota (3), przy czym przeciwciało (6) połączone jest wiązaniem kowalencyjnym za pośrednictwem linkera w postaci cysteaminy (5).The subject of the application is a biosensor for specific determination of mesothelin in body fluids and tissue homogenates using the Imaging version of the matrix surface plasmon resonance technique, which consists of a glass plate (1) covered with a gold layer (3) on a titanium substrate (3) and a polymer mesh (4) forming a cluster of active sites containing a receptor layer, which is a rabbit monoclonal antibody specific for mesothelin (6), immobilized on the gold surface (3), wherein the antibody (6) is connected by a covalent bond via a cysteamine linker (5).

PL447285A 2023-12-27 2023-12-27 Biosensor for mesothelin determination using matrix surface plasmon resonance technique in Imaging version PL447285A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL447285A PL447285A1 (en) 2023-12-27 2023-12-27 Biosensor for mesothelin determination using matrix surface plasmon resonance technique in Imaging version

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL447285A PL447285A1 (en) 2023-12-27 2023-12-27 Biosensor for mesothelin determination using matrix surface plasmon resonance technique in Imaging version

Publications (1)

Publication Number Publication Date
PL447285A1 true PL447285A1 (en) 2025-06-30

Family

ID=96171633

Family Applications (1)

Application Number Title Priority Date Filing Date
PL447285A PL447285A1 (en) 2023-12-27 2023-12-27 Biosensor for mesothelin determination using matrix surface plasmon resonance technique in Imaging version

Country Status (1)

Country Link
PL (1) PL447285A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013172866A2 (en) * 2012-05-12 2013-11-21 Andraka Jack Thomas Sensors for detection of mesothelin
WO2020007134A1 (en) * 2018-07-06 2020-01-09 深圳信息职业技术学院 Optical fiber immunosensor, detection device and preparation method for optical fiber immunosensor
PL430495A1 (en) * 2019-07-04 2021-01-11 Politechnika Poznańska Biosensor for specific determination of cathepsin S concentration in body fluids and tissue homogenates by means of surface plasmon resonance imaging
PL432021A1 (en) * 2019-11-29 2021-05-31 Politechnika Poznańska Biosensor for specific determination of the concentration of the human carcinoembryonic CEA antigen
PL433106A1 (en) * 2020-03-02 2021-09-06 Politechnika Poznańska Biosensor for the determination of interleukin 6 (IL-6) by surface plasmon resonance imaging

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013172866A2 (en) * 2012-05-12 2013-11-21 Andraka Jack Thomas Sensors for detection of mesothelin
WO2020007134A1 (en) * 2018-07-06 2020-01-09 深圳信息职业技术学院 Optical fiber immunosensor, detection device and preparation method for optical fiber immunosensor
PL430495A1 (en) * 2019-07-04 2021-01-11 Politechnika Poznańska Biosensor for specific determination of cathepsin S concentration in body fluids and tissue homogenates by means of surface plasmon resonance imaging
PL432021A1 (en) * 2019-11-29 2021-05-31 Politechnika Poznańska Biosensor for specific determination of the concentration of the human carcinoembryonic CEA antigen
PL433106A1 (en) * 2020-03-02 2021-09-06 Politechnika Poznańska Biosensor for the determination of interleukin 6 (IL-6) by surface plasmon resonance imaging

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
E.F. DE MACEDO ET AL.: "Sensing and Bio-Sensing Research 43 (2024) 100609, dostępny on-line 27.11.2023", SIMULTANEOUS DETECTION OF CA-125 AND MESOTHELIN BY GOLD NANOPARTICLES IN SURFACE PLASMON RESONANCE *

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